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Surface-enhanced Raman scattering for protein detection

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Abstract

Proteins are essential components of organisms and they participate in every process within cells. The key characteristic of proteins that allows their diverse functions is their ability to bind other molecules specifically and tightly. With the development of proteomics, exploring high-efficiency detection methods for large-scale proteins is increasingly important. In recent years, rapid development of surface-enhanced Raman scattering (SERS)-based biosensors leads to the SERS realm of applications from chemical analysis to nanostructure characterization and biomedical applications. For proteins, early studies focused on investigating SERS spectra of individual proteins, and the successful design of nanoparticle probes has promoted great progress of SERS-based immunoassays. In this review we outline the development of SERS-based methods for proteins with particular focus on our proposed protein-mediated SERS-active substrates and their applications in label-free and Raman dye-labeled protein detection.

Protein-mediated SERS-active substrates for protein detection

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Acknowledgments

These studies were supported by the National Natural Science Foundation (Grant Nos. 20573041, 20773044, 20873050) of P.R. China; by the Program for Changjiang Scholars and Innovative Research Team in University (IRT0422), Program for New Century Excellent Talents in University; the 111 project (B06009), the Development Program of the Science and Technology of Jilin Province (20060902–02). This work was also supported by KAKENHI (Grant-in-Aid for Scientific Research) on Priority Area “Strong Photon-Molecule Coupling Fields (No. 470, 20043032)” from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China

    Xiao X. Han & Bing Zhao

  2. Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, 669–1337, Japan

    Xiao X. Han & Yukihiro Ozaki

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  1. Xiao X. Han
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  2. Bing Zhao
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Correspondence to Bing Zhao or Yukihiro Ozaki.

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Han, X.X., Zhao, B. & Ozaki, Y. Surface-enhanced Raman scattering for protein detection. Anal Bioanal Chem 394, 1719–1727 (2009). https://doi.org/10.1007/s00216-009-2702-3

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