Abstract
Natural products are a source of unique chemical entities with specific biological activities of great value to the pharmaceutical industry. However, the determination of unknown structures is usually time consuming and often becomes a bottleneck in the effort to develop natural products into effective drugs. The high-performance features of high magnetic field FTMS have greatly alleviated the structural elucidation bottleneck to meet increasingly shorter discovery timelines for drug candidates based on natural products. The high-performance features of high field FTMS include unsurpassed mass measurement accuracy for elemental formula determination, ultra-high mass resolution for component separation, the ability to perform multiple levels of tandem mass spectrometry for structural elucidation, and moderate sensitivity for limited supply of isolates. A number of applications utilizing these properties of FTMS have been reported recently for the structural elucidation of novel natural product structures originating from terrestrial and marine microorganisms. In this review, FTMS methods and their applications for the structural elucidation and characterization of natural products will be reviewed.
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Acknowledgements
The authors greatly appreciate the help provided by Drs Mark Tischler, Frank E. Koehn, and Guy T. Carter in critically reviewing the manuscript. The contributions to structural elucidation by our colleagues at the Wyeth Research Natural Products Department are gratefully acknowledged. We are indebted to Drs Damian W. Laird, Tim S. Bugni, Rohan A. Davis and Chris M. Ireland at University of Utah and Drs David E. Williams and Raymond J. Andersen at University of British Columbia for providing challenging natural product structure determination problems.
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Feng, X., Siegel, M.M. FTICR-MS applications for the structure determination of natural products. Anal Bioanal Chem 389, 1341–1363 (2007). https://doi.org/10.1007/s00216-007-1468-8
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DOI: https://doi.org/10.1007/s00216-007-1468-8