Abstract
Modern sanitary practices result in large volumes of human waste, as well as domestic and industrial sewage, being collected and treated at common collection points, wastewater treatment plants (WWTPs). In recognition of the growing use of sewage sludge as fertilizers and soil amendments, and the scarcity of current data regarding the chemical constituents in sewage sludge, the US National Research Council (NRC) in 2002 produced a report on sewage sludge. Among the NRC’s recommendations was the need for investigating the occurrence of pharmaceuticals and personal care products (PPCPs) in sewage sludge. PPCPs are a diverse array of non-regulated contaminants that had not been studied in previous sewage sludge surveys but which are likely to be present. The focus of this paper will be to review the current analytical methodologies available for investigating whether pharmaceuticals are present in WWTP-produced sewage sludge, to summarize current regulatory practices regarding sewage sludge, and to report on the presence of pharmaceuticals in sewage sludge.
Similar content being viewed by others
References
United States Federal Register (1993) 40 CFR Part 503: standards for the use and disposal of sewage sludge 58:9248–9404
Biosolids generation, use, and disposal in the United States (1999) US Environmental Protection Agency, Municipal and Industrial Solid Waste Division, Office of Solid Waste, EPA530-R-99-009, September 1999
Goldstein N (2000) The state of biosolids in America. BioCycle
National Research Council report to EPA (2002) Biosolids applied to land: advancing standards and practices. http://www.epa.gov/ost/biosolids/nas/complete.pdf. Accessed 02 June 2006
McFarland M (2001) Biosolids Engineering. McGraw-Hill, New York, NY USA
Conveyance of residuals from water and wastewater treatment (2000) ASCE manuals and reports on engineering practice No 98. American Society of Civil Engineers (2000), Reston, VA
Rogers HR (1996) Sci Total Environ 185:3–26
Khan SJ, Ongerth JE (2002) Water Sci Technol 46(3):105–113
Gomez A, Leschber R, L’Hermite P (eds) (1986) Sampling problems for the chemical analysis of sludge, soils and plants. Elsevier, Essex, England
Eljarrat E, Caixach J, Rivera J (1999) Environ Sci Technol 33:2493–2498
Molina L, Diaz-Ferrero J, Coll M, Marti R, Broto-Puig F, Comellas L, Rodriguez-Larena MC (2000) Chemosphere 40:1173–1178
Rideout K, Teschke K (2004) Environ Health Perspect 112:959–969
Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002) Environ Sci Technol 36:1202–1211
Jones-Lepp TL, Alvarez D, Petty J, Huggins J (2004) Arch Environ Cont Toxicol 47:427–439
Alvarez DA, Petty JD, Huckins JN, Jones-Lepp TL, Getting DT, Manahan SE (2004) Environ Toxicol Chem 23:1640–1648
Abuin S, Codony R, Compaòo R, Granados M, Prat MD (2006) J Chromatogr A 1114:73–81
Ellis JB (2006) Pharmaceutical and personal care products (PPCPs) in urban receiving waters. (2006) Environ Pollut (in press). Last web accessed 14 June 2006
Jones-Lepp TL (2006) J Environ Monit 8:472–478
Richardson ML, Bowron JM (1985) J Pharm Pharmacol 37:1–12
Stevens JL, Northcott GL, Stern GA, Tomy GT, Jones KC (2003) Environ Sci Technol 37:462–467
Osemwengie L (2006) in press J Environ Monitor, last web accessed 14 June 2006
Kupper T, Berset JD, Etter-Holzer R, Furrere R, Tarradellas J (2004) Chemosphere 54:1111–1120
Telscher M, Schuller U, Schmidt B, Schaffer A (2005) Environ Sci Technol 39:7896–7900
La Guardia M, Hale RC, Harvey E, Mainor TM (2001) Environ Sci Technol 35:4798–4804
Pryor SW, Hay AG, Walker LP (2002) Environ Sci Technol 36:3678–3682
la Farre M, Garcia M-J, Castillo M, Riu J, Barcelo D (2001) J Environ Monit 3:232–237
Petrovic M, Barcelo D, Diaz A, Ventura F (2003) J Am Soc Mass Spectrom 14:515–527
Kim S, Eichhorn P, Jensen J, Weber AS, Aga DS (2005) Environ Sci Technol 39:5816–5823
Jacobsen AM, Halling-Sørensen B (2006) Anal Bioanal Chem 384:1164–1174
Golet EM, Strehler A, Alder A, Giger W (2002) Anal Chem 74:5455–5462
Heidler J, Sapkota A, Halden R (2006) Environ Sci Technol 40:3634–3639
Göbel A, Thomsen A, McArdell CS, Alder AC, Giger W, Theiß N, Löffler D, Ternes TA (2005) J Chromatogr A 1085:179–189
Kinney CA, Furlong ET, Zaugg SD, Burkhardt MR, Werner SL, Cahill JD, Jorgensen GJ (2006) Survey of organic wastewater contaminants in biosolids destined for land application. Environ Sci Technol (in press)
Kaleta A, Ferdig M, Buchberger W (2006) J Sep Sci 29:1662–1666
United States Federal Register 68 FR 17379 Wednesday April 9, 2003, pp 17379–17395
United States Federal Register 68 FR 75531 Wednesday December 31, 2003, pp 75531–75552
Iranpour R, Cox HHJ, Kearney RJ, Clark JH, Pincince AB, Daigger GT (2004) J Residuals Sci Technol 1:209–222
Council of the European Communities (1986) Council directive 86/278/EEC of 12 June 1986 on the protection of the environment, and in particular of the soil, when sewage sludge is used in agriculture. Official J L 181:0006–0012
Bucket N (ed) (2002) Municipal waste management in Europe. European policy between hamonisation and subsidiarity. Environment & management, Vol II. Kluwer Academic, Netherlands
Matthews P (1997) Transatlantic comparison of biosolids practices. Proceedings Water Residuals and Biosolids Management: Approaching the Year 2000 WEF/AWWA Joint Conference, Aug 3–6, Philadelphia, Pennsylvania, 16–9/32
Magoarou P (1999) Urban waste water in Europe-what about the sludge? Proceedings Workshop on Problems around Sludge. Directorate-General for the Environment and Joint Research Centre of the Eurpoean Commission, Nov. 19–20, Stressa, Italy, 9–16
Aubain P, Gazzo A, LeMoux J, Mugnier E, Brunet H, Landrea B (2002) Disposal and Recycling Routes for Sewage Sludge. Synthesis report for the European Commission DG Environment-B/2
Erhardt W, Prüeß A (2001) Organic contaminants in sewage sludge for agricultural use. Report for the European Commission Joint Research Centre, Institute for Environment and Sustainability Soil and Waste Unit
Thornton I, Butler D, Docx P, Hession M, Makropoulos C, McMullen M, Nieuwenhuijsen M, Pitman A, Rautiu R, Sawyer R, Smith S, White D, Wilderer P, Paris S, Marani D, Braguglia C, Palerm J (2001) Pollutants in urban waste water and sewage sludge. Final report prepared for European Commission Directorate-General Environment
Angus B (2002) Simple Methods to Reduce Potential Transfer of Organic Chemical Residues from Sewage Sludge Amended Soils to Food Crops. Briefing Note No. 4, Centre for Food Chain Research, Imperial College, London, England
Bound JA, Voulvoulis N (2005) Environ Health Perspect 113:1705–1711
Acknowledgements
TLJ-L would like to thank her technical senior environmental employee, Mr. Tom Moy, for all of his hard work and assistance in the day-to-day laboratory operations.
Disclaimer
The US Environmental Protection Agency (EPA), through its Office of Research and Development (ORD), funded and performed the research described. It has been subjected to the Agency’s administrative review and approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or recommendation by EPA for use.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jones-Lepp, T.L., Stevens, R. Pharmaceuticals and personal care products in biosolids/sewage sludge: the interface between analytical chemistry and regulation. Anal Bioanal Chem 387, 1173–1183 (2007). https://doi.org/10.1007/s00216-006-0942-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00216-006-0942-z