Skip to main content
Log in

Pharmaceuticals and personal care products in biosolids/sewage sludge: the interface between analytical chemistry and regulation

  • Review
  • Published:
Analytical and Bioanalytical Chemistry Aims and scope Submit manuscript

Abstract

Modern sanitary practices result in large volumes of human waste, as well as domestic and industrial sewage, being collected and treated at common collection points, wastewater treatment plants (WWTPs). In recognition of the growing use of sewage sludge as fertilizers and soil amendments, and the scarcity of current data regarding the chemical constituents in sewage sludge, the US National Research Council (NRC) in 2002 produced a report on sewage sludge. Among the NRC’s recommendations was the need for investigating the occurrence of pharmaceuticals and personal care products (PPCPs) in sewage sludge. PPCPs are a diverse array of non-regulated contaminants that had not been studied in previous sewage sludge surveys but which are likely to be present. The focus of this paper will be to review the current analytical methodologies available for investigating whether pharmaceuticals are present in WWTP-produced sewage sludge, to summarize current regulatory practices regarding sewage sludge, and to report on the presence of pharmaceuticals in sewage sludge.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. United States Federal Register (1993) 40 CFR Part 503: standards for the use and disposal of sewage sludge 58:9248–9404

  2. Biosolids generation, use, and disposal in the United States (1999) US Environmental Protection Agency, Municipal and Industrial Solid Waste Division, Office of Solid Waste, EPA530-R-99-009, September 1999

  3. Goldstein N (2000) The state of biosolids in America. BioCycle

  4. National Research Council report to EPA (2002) Biosolids applied to land: advancing standards and practices. http://www.epa.gov/ost/biosolids/nas/complete.pdf. Accessed 02 June 2006

  5. McFarland M (2001) Biosolids Engineering. McGraw-Hill, New York, NY USA

    Google Scholar 

  6. Conveyance of residuals from water and wastewater treatment (2000) ASCE manuals and reports on engineering practice No 98. American Society of Civil Engineers (2000), Reston, VA

  7. Rogers HR (1996) Sci Total Environ 185:3–26

    Article  CAS  Google Scholar 

  8. Khan SJ, Ongerth JE (2002) Water Sci Technol 46(3):105–113

    CAS  Google Scholar 

  9. Gomez A, Leschber R, L’Hermite P (eds) (1986) Sampling problems for the chemical analysis of sludge, soils and plants. Elsevier, Essex, England

    Google Scholar 

  10. Eljarrat E, Caixach J, Rivera J (1999) Environ Sci Technol 33:2493–2498

    Article  CAS  Google Scholar 

  11. Molina L, Diaz-Ferrero J, Coll M, Marti R, Broto-Puig F, Comellas L, Rodriguez-Larena MC (2000) Chemosphere 40:1173–1178

    Article  CAS  Google Scholar 

  12. Rideout K, Teschke K (2004) Environ Health Perspect 112:959–969

    Google Scholar 

  13. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002) Environ Sci Technol 36:1202–1211

    Article  CAS  Google Scholar 

  14. Jones-Lepp TL, Alvarez D, Petty J, Huggins J (2004) Arch Environ Cont Toxicol 47:427–439

    Article  CAS  Google Scholar 

  15. Alvarez DA, Petty JD, Huckins JN, Jones-Lepp TL, Getting DT, Manahan SE (2004) Environ Toxicol Chem 23:1640–1648

    Article  CAS  Google Scholar 

  16. Abuin S, Codony R, Compaòo R, Granados M, Prat MD (2006) J Chromatogr A 1114:73–81

    Article  CAS  Google Scholar 

  17. Ellis JB (2006) Pharmaceutical and personal care products (PPCPs) in urban receiving waters. (2006) Environ Pollut (in press). Last web accessed 14 June 2006

  18. Jones-Lepp TL (2006) J Environ Monit 8:472–478

    Article  CAS  Google Scholar 

  19. Richardson ML, Bowron JM (1985) J Pharm Pharmacol 37:1–12

    CAS  Google Scholar 

  20. Stevens JL, Northcott GL, Stern GA, Tomy GT, Jones KC (2003) Environ Sci Technol 37:462–467

    Article  CAS  Google Scholar 

  21. Osemwengie L (2006) in press J Environ Monitor, last web accessed 14 June 2006

  22. Kupper T, Berset JD, Etter-Holzer R, Furrere R, Tarradellas J (2004) Chemosphere 54:1111–1120

    Article  CAS  Google Scholar 

  23. Telscher M, Schuller U, Schmidt B, Schaffer A (2005) Environ Sci Technol 39:7896–7900

    Article  CAS  Google Scholar 

  24. La Guardia M, Hale RC, Harvey E, Mainor TM (2001) Environ Sci Technol 35:4798–4804

    Article  Google Scholar 

  25. Pryor SW, Hay AG, Walker LP (2002) Environ Sci Technol 36:3678–3682

    Article  CAS  Google Scholar 

  26. la Farre M, Garcia M-J, Castillo M, Riu J, Barcelo D (2001) J Environ Monit 3:232–237

    Article  Google Scholar 

  27. Petrovic M, Barcelo D, Diaz A, Ventura F (2003) J Am Soc Mass Spectrom 14:515–527

    Article  Google Scholar 

  28. Kim S, Eichhorn P, Jensen J, Weber AS, Aga DS (2005) Environ Sci Technol 39:5816–5823

    Article  CAS  Google Scholar 

  29. Jacobsen AM, Halling-Sørensen B (2006) Anal Bioanal Chem 384:1164–1174

    Article  CAS  Google Scholar 

  30. Golet EM, Strehler A, Alder A, Giger W (2002) Anal Chem 74:5455–5462

    Article  CAS  Google Scholar 

  31. Heidler J, Sapkota A, Halden R (2006) Environ Sci Technol 40:3634–3639

    Article  CAS  Google Scholar 

  32. Göbel A, Thomsen A, McArdell CS, Alder AC, Giger W, Theiß N, Löffler D, Ternes TA (2005) J Chromatogr A 1085:179–189

    Article  Google Scholar 

  33. Kinney CA, Furlong ET, Zaugg SD, Burkhardt MR, Werner SL, Cahill JD, Jorgensen GJ (2006) Survey of organic wastewater contaminants in biosolids destined for land application. Environ Sci Technol (in press)

  34. Kaleta A, Ferdig M, Buchberger W (2006) J Sep Sci 29:1662–1666

    Article  CAS  Google Scholar 

  35. United States Federal Register 68 FR 17379 Wednesday April 9, 2003, pp 17379–17395

  36. United States Federal Register 68 FR 75531 Wednesday December 31, 2003, pp 75531–75552

  37. Iranpour R, Cox HHJ, Kearney RJ, Clark JH, Pincince AB, Daigger GT (2004) J Residuals Sci Technol 1:209–222

    Google Scholar 

  38. Council of the European Communities (1986) Council directive 86/278/EEC of 12 June 1986 on the protection of the environment, and in particular of the soil, when sewage sludge is used in agriculture. Official J L 181:0006–0012

  39. Bucket N (ed) (2002) Municipal waste management in Europe. European policy between hamonisation and subsidiarity. Environment & management, Vol II. Kluwer Academic, Netherlands

    Google Scholar 

  40. Matthews P (1997) Transatlantic comparison of biosolids practices. Proceedings Water Residuals and Biosolids Management: Approaching the Year 2000 WEF/AWWA Joint Conference, Aug 3–6, Philadelphia, Pennsylvania, 16–9/32

  41. Magoarou P (1999) Urban waste water in Europe-what about the sludge? Proceedings Workshop on Problems around Sludge. Directorate-General for the Environment and Joint Research Centre of the Eurpoean Commission, Nov. 19–20, Stressa, Italy, 9–16

  42. Aubain P, Gazzo A, LeMoux J, Mugnier E, Brunet H, Landrea B (2002) Disposal and Recycling Routes for Sewage Sludge. Synthesis report for the European Commission DG Environment-B/2

  43. Erhardt W, Prüeß A (2001) Organic contaminants in sewage sludge for agricultural use. Report for the European Commission Joint Research Centre, Institute for Environment and Sustainability Soil and Waste Unit

  44. Thornton I, Butler D, Docx P, Hession M, Makropoulos C, McMullen M, Nieuwenhuijsen M, Pitman A, Rautiu R, Sawyer R, Smith S, White D, Wilderer P, Paris S, Marani D, Braguglia C, Palerm J (2001) Pollutants in urban waste water and sewage sludge. Final report prepared for European Commission Directorate-General Environment

  45. Angus B (2002) Simple Methods to Reduce Potential Transfer of Organic Chemical Residues from Sewage Sludge Amended Soils to Food Crops. Briefing Note No. 4, Centre for Food Chain Research, Imperial College, London, England

  46. Bound JA, Voulvoulis N (2005) Environ Health Perspect 113:1705–1711

    Article  Google Scholar 

Download references

Acknowledgements

TLJ-L would like to thank her technical senior environmental employee, Mr. Tom Moy, for all of his hard work and assistance in the day-to-day laboratory operations.

Disclaimer

The US Environmental Protection Agency (EPA), through its Office of Research and Development (ORD), funded and performed the research described. It has been subjected to the Agency’s administrative review and approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or recommendation by EPA for use.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. L. Jones-Lepp.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jones-Lepp, T.L., Stevens, R. Pharmaceuticals and personal care products in biosolids/sewage sludge: the interface between analytical chemistry and regulation. Anal Bioanal Chem 387, 1173–1183 (2007). https://doi.org/10.1007/s00216-006-0942-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00216-006-0942-z

Keywords

Navigation