Skip to main content
SpringerLink
Log in

Radical polymerization in biosensing

  • Review
  • Published:
Analytical and Bioanalytical Chemistry Aims and scope Submit manuscript

Abstract

This review briefly summarizes recently published work on radical polymerization in biosensor-related applications. Advancements in surface modification aimed at improving sensor biocompatibility and reducing nonspecific background noises are discussed. Direct applications of polymers as one of the key sensing elements in which they are used either as detection probes for the biomolecular binding events or as signal transducers to amplify sensing signals are detailed. Initial applications of radical polymerization reactions in biosensing are evident and appear promising.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2a–b
Fig. 3a–b
Fig. 4

Similar content being viewed by others

References

  1. Gerard M, Chaubey A, Malhotra BD (2002) Biosensor Bioelectron 17:345–359

    Article  CAS  Google Scholar 

  2. Sadik OA (1999) Electroanalysis 11:839–844

    Article  CAS  Google Scholar 

  3. Persaud KC (2005) Mater Today 8:38–44

    Article  CAS  Google Scholar 

  4. Xu H, Wu H, Fan C, Li W, Zhang Z, He L (2004) Chinese Sci Bull 49:2227–2231

    Article  CAS  Google Scholar 

  5. McQuade DT, Pullen AE, Swager TM (2000) Chem Rev 100:2537–2574

    Article  CAS  Google Scholar 

  6. Achyuthan KE, Bergstedt TS, Chen L, Jones RM, Kumaraswamy S, Kushon SA, Ley KD, Lu L, McBranch D, Mukundan H, Rininsland F, Shi X, Xia W, Whitten DG (2005) J Mater Chem 15:2648–2656

    Article  CAS  Google Scholar 

  7. Kim S-H, Kim B, Yadavalli VK, Pishko MV (2005) Anal Chem 77:6828–6833

    Article  CAS  Google Scholar 

  8. Trojanowicz M (2003) Microchim Acta 143:75–91

    Article  CAS  Google Scholar 

  9. Cosnier S (2005) Electroanal 17:1701–1715

    Article  CAS  Google Scholar 

  10. Reuber J, Reinhardt H, Johannsmann D (2006) Langmuir 22:3362–3367

    Article  CAS  Google Scholar 

  11. Lamb DJ, Fellows CM, Gilbert RG (2005) Polymer 46:7874–7895

    Article  CAS  Google Scholar 

  12. Matyjaszewski K, Spanswick J (2005) Mater Today 8:26–33

    Article  CAS  Google Scholar 

  13. Matyjaszewski K, Beers KL, Woodworth B, Metzner Z (2001) J Chem Edu 78:547–550

    Article  CAS  Google Scholar 

  14. Kamigaito M, Ando T, Sawamoto M (2001) Chem Rev 101:3689–3745

    Article  CAS  Google Scholar 

  15. Xu FJ, Cai QJ, Li YL, Kang ET, Neoh KG (2005) Biomacromolecules 6:1012–1020

    Article  CAS  Google Scholar 

  16. Lou X, Lewis MS, Gorman CB, He L (2005) Anal Chem 77:4698–4705

    Article  CAS  Google Scholar 

  17. McCormick CL, Lowe AB (2004) Acc Chem Res 37:312–325

    Article  CAS  Google Scholar 

  18. Lowe AB, McCormick CL (2002) Chem Rev 102:4177–4189

    Article  CAS  Google Scholar 

  19. Smulders W, Monteiro MJ (2004) Macromolecules 37:4474–4483

    Article  CAS  Google Scholar 

  20. Scales CW, Myrick LJ, Sumerlin BS, Lowe AB, McCormick CL (2004) PMSE Prepr 90:36–37

    CAS  Google Scholar 

  21. von Werne TA, Germack DS, Hagberg EC, Sheares VV, Hawker CJ, Carter KR (2003) J Am Chem Soc 125:3831–3838

    Article  CAS  Google Scholar 

  22. Hutchison JB, Stark PF, Hawker CJ, Anseth KS (2005) Chem Mater 17:4789–4797

    Article  CAS  Google Scholar 

  23. Croce TA, Funk MA, Adkins CT, Harth E (2005) PMSE Prepr 93:568

    CAS  Google Scholar 

  24. Janata J, Josowicz M (2003) Nature Mater 2:19–24

    Article  CAS  Google Scholar 

  25. Livache T, Maillart E, Lassalle N, Mailley P, Corso B, Guedon P, Roget A, Levy Y (2003) J Pharm Biomed Anal 32:687–696

    Article  CAS  Google Scholar 

  26. Garnier F, Korri-Youssoufi H, Srivastava P, Mandrand B, Delair T (1999) Synth Metals 100:89–94

    Article  CAS  Google Scholar 

  27. Ansell RJ (2005) Molec Imprint Mater 641–683

  28. Wei X, Li X, Husson SM (2005) Biomacromolecules 6:1113–1121

    Article  CAS  Google Scholar 

  29. Henry OYF, Cullen DC, Piletsky SA (2005) Anal Bioanal Chem 382:947–956

    Article  CAS  Google Scholar 

  30. Guo T-Y, Xia Y-Q, Hao G-J, Zhang B-H, Fu G-Q, Yuan, Z, He B-L, Kennedy JF (2005) Carbohydrate Polym 62:214–221

    Article  CAS  Google Scholar 

  31. Arslan A, Kiralp S, Toppare L, Bozkurt A (2006) Langmuir 22:2912–2915

    Article  CAS  Google Scholar 

  32. Smith EA, Coym JW, Cowell SM, Tokimoto T, Hruby VJ, Yamamura HI, Wirth MJ (2005) Langmuir 21:9644–9650

    Article  CAS  Google Scholar 

  33. Komori K, Takada K, Tatsuma T (2006) Langmuir 22:478–483

    Article  CAS  Google Scholar 

  34. Masson J-F, Battaglia TM, Davidson MJ, Kim Y-C, Prakash AMC, Beaudoin S, Booksh KS (2005) Talanta 67:918–925

    Article  CAS  Google Scholar 

  35. Minard-Basquin C, Chaix C, Pichot C, Mandrand B (2000) Bioconj Chem 11:795–804

    Article  CAS  Google Scholar 

  36. Renner C, Piehler J, Schrader T (2006) J Am Chem Soc 128:620–628

    Article  CAS  Google Scholar 

  37. Fernandez E, Lopez D, Lopez-Cabarcos E, Mijangos C (2005) Polymer 46:2211–2217

    Article  CAS  Google Scholar 

  38. Hawkins DM, Stevenson D, Reddy SM (2005) Anal Chim Acta 542:61–65

    Article  CAS  Google Scholar 

  39. Yu WH, Kang ET, Neoh KG, Zhu S (2003) J Phys Chem B 107:10198–10205

    Article  CAS  Google Scholar 

  40. Liu B, Bazan GC (2004) Chem Mater 16:4467–4476

    Article  CAS  Google Scholar 

  41. Kizhakkedathu JN, Norris-Jones R, Brooks DE (2004) Macromolecules 37:734–743

    Article  CAS  Google Scholar 

  42. Jeyaprakash JD, Samuel S, Dhamodharan R, Ruhe J (2002) Macromol Rapid Comm 23:277–281

    Article  CAS  Google Scholar 

  43. Ma HW, Hyun JH, Stiller P, Chilkoti A (2004) Adv Mater 16:338–341

    Article  CAS  Google Scholar 

  44. Andruzzi L, Senaratne W, Hexemer A, Sheets ED, Ilic B, Kramer EJ, Baird B, Ober CK (2005) Langmuir 21:2495–2504

    Article  CAS  Google Scholar 

  45. Chang Y, Chen S, Zhang Z, Jiang S (2006) Langmuir 22:2222–2226

    Article  CAS  Google Scholar 

  46. Nagasaki Y, Kataoka K (2005) IEE Proc-Nanobiotechnol 152:89–96

    Article  CAS  Google Scholar 

  47. Mahony JO, Nolan K, Smyth MR, Mizaikoff B (2005) Anal Chim Acta 534:31–39

    Article  CAS  Google Scholar 

  48. Haupt K (2003) Chem Commun 2:171–178

    Article  CAS  Google Scholar 

  49. Rachkov A, Minoura N (2001) Biochim Biophys Acta 1544:255–266

    CAS  Google Scholar 

  50. Pitschke M, Fels A, Schmidt B, Heiliger L, Kuckert E, Riesner D (1995) Colloid Polym Sci 273:740–752

    Article  CAS  Google Scholar 

  51. Kanekiyo Y, Sato H, Tao H (2005) Macromol Rapid Comm 26:1542–1546

    Article  CAS  Google Scholar 

  52. Asher SA, Alexeev VL, Goponenko AV, Sharma AC, Lednev IK, Wilcox CS, Finegold DN (2003) J Am Chem Soc 125:3322–3329

    Article  CAS  Google Scholar 

  53. Murakami Y, Maeda M (2005) Biomacromolecules 6:2927–2929

    Article  CAS  Google Scholar 

  54. Wang J, Jiang M, Nilsen TW, Getts RC (1998) J Am Chem Soc 120:8281–8282

    Article  CAS  Google Scholar 

  55. Besselink GAJ, Kooyman RPH, van Os PJHJ, Engbers GHM, Schasfoort RBM (2004) Anal Biochem 333:165–173

    Article  CAS  Google Scholar 

  56. Zhang S, Yang W, Niu Y, Sun C (2004) Sensor Actuat B 101:387–393

    Article  CAS  Google Scholar 

  57. Calleja M, Nordstroem M, Alvarez M, Tamayo J, Lechuga LM, Boisen A (2005) Ultramicroscopy 105:215–222

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA

    Xinhui Lou, Peng He, Geoffrey O. Okelo & Lin He

Authors
  1. Xinhui Lou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peng He
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Geoffrey O. Okelo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lin He
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lin He.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lou, X., He, P., Okelo, G.O. et al. Radical polymerization in biosensing. Anal Bioanal Chem 386, 525–531 (2006). https://doi.org/10.1007/s00216-006-0576-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00216-006-0576-1

Keywords

Search

Navigation