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ICP-MS multielemental determination of metals potentially released from dental implants and articular prostheses in human biological fluids

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Abstract

A sector field high-resolution (HR)-ICP-MS and an octapole reaction system (ORS)-ICP-MS have been compared for the simultaneous determination of traces of metals (Ti, V, Cr, Co, Ni, and Mo) released from dental implants and articular prostheses in human biological fluids. Optimum sample treatments were evaluated to minimize matrix effects in urine and whole blood. Urine samples were diluted tenfold with ultrapure water, whereas whole blood samples were digested with high-purity nitric acid and hydrogen peroxide and finally diluted tenfold with ultrapure water. In both matrices, internal standardization (Ga and Y) was employed to avoid potential matrix interferences and ICP-MS signal drift. Spectral interferences arising from the plasma gases or the major components of urine and whole blood were identified by (HR)-ICP-MS at 3,000 resolving power. The capabilities of (HR)-ICP-MS and (ORS)-ICP-MS for the removal of such spectral interferences were evaluated and compared. Results indicate that polyatomic interferences, which hamper the determination of such metallic elements in these biological samples, could be overcome by using a resolving power of 3,000. Using (ORS)-ICP-MS, all those elements could be quantified except Ti and V (due to the polyatomic ions 31P16O and 35Cl16O, respectively). The accuracy of the proposed methodologies by (HR)- and (ORS)-ICP-MS was checked against two reference materials. Good agreement between the given values and the concentrations obtained for all the analytes under scrutiny was found except for Ti and V when analyzed by (ORS)-ICP-MS.

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Acknowledgements

The authors are grateful to the “Fundación para la Investigación Científica Aplicada y la Tecnología” (FICYT) del Principado de Asturias (Spain) for the Project reference PC-SPV01 06. Funding of this work through the Spanish Ministry of Science and Technology project BQU2003-04671 is also acknowledged.

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Authors and Affiliations

  1. Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Julián Clavería 8, 33006, Oviedo, Spain

    Alejandro Sarmiento-González, Juan Manuel Marchante-Gayón & Alfredo Sanz-Medel

  2. Department of Stomatology, School of Stomatology, University of Oviedo, Catedrático José Serrano s/n, 33006, Oviedo, Spain

    José María Tejerina-Lobo

  3. Department of Surgery, Faculty of Medicine, University of Oviedo, Julián Clavería 6, 33006, Oviedo, Spain

    José Paz-Jiménez

Authors
  1. Alejandro Sarmiento-González
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  2. Juan Manuel Marchante-Gayón
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  3. José María Tejerina-Lobo
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  4. José Paz-Jiménez
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  5. Alfredo Sanz-Medel
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Correspondence to Alfredo Sanz-Medel.

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Sarmiento-González, A., Marchante-Gayón, J.M., Tejerina-Lobo, J.M. et al. ICP-MS multielemental determination of metals potentially released from dental implants and articular prostheses in human biological fluids. Anal Bioanal Chem 382, 1001–1009 (2005). https://doi.org/10.1007/s00216-005-3165-9

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  • DOI: https://doi.org/10.1007/s00216-005-3165-9

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