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Retention characteristics of a new butylimidazolium-based stationary phase

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Abstract

A new HPLC stationary phase has been synthesized based on the ionic liquid n-butylimidazolium bromide. Imidazolium was covalently immobilized on a silica substrate through an n-alkyl tether and the retention characteristics of the resulting stationary phase were evaluated systematically. Using 28 small aromatic test solutes and reversed phase conditions, the linear solvation energy relationship approach was successfully used to characterize this new phase. The retention characteristics of the test solutes show remarkable similarity with phenyl stationary phases, despite the presence of a positive charge on the new imidazolium phase. Operated in the reversed phase mode, this new stationary phase shows considerable promise for the separation of neutral solutes and points to the potential for a truly multi-modal stationary phase.

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Acknowledgements

The authors gratefully acknowledge support from the Waters Corporation and the National Institutes of Health (GM61991-01).

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Author notes

  1. B. Cabovska

    Present address: PPRU-Laboratory of Applied Pharmacokinetics and Therapeutic Drug Management, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA

  2. C. E. Evans

    Present address: Department of Chemistry, 215 UCB, University of Colorado, Boulder, CO, 80309, USA

Authors and Affiliations

  1. Department of Chemistry, University of Cincinnati, Cincinnati, OH, 45221-0172, USA

    Y. Sun, B. Cabovska, C. E. Evans, T. H. Ridgway & A. M. Stalcup

Authors
  1. Y. Sun
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  2. B. Cabovska
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  3. C. E. Evans
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  4. T. H. Ridgway
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  5. A. M. Stalcup
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Corresponding author

Correspondence to A. M. Stalcup.

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Sun, Y., Cabovska, B., Evans, C.E. et al. Retention characteristics of a new butylimidazolium-based stationary phase. Anal Bioanal Chem 382, 728–734 (2005). https://doi.org/10.1007/s00216-004-3051-x

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  • DOI: https://doi.org/10.1007/s00216-004-3051-x

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