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Determination of the MRI contrast agent Gd-DTPA by SEC–ICP–MS

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Abstract

The simultaneous determination of Gd3+ and Gd-DTPA (DTPA: diethylenetriamino-pentaacetic acid), often used as contrast agent, is described. The proposed approach combines size-exclusion chromatography (SEC) and inductively coupled plasma–mass spectrometry (ICP–MS) for element-selective detection in order to determine also high-molecular Gd-complexes if present. This method was applied to the analysis of urine samples of a patient to whom Gd-DTPA was intravenously administered. The results showed that no conversion or adsorption of Gd-DTPA could be observed in any sample, even free Gd3+ could not be detected. Urine excretion behaviour was monitored and it was proved that Gd-DTPA was almost completely (>99%) excreted by urination within one day. Traces of Gd-DTPA could be measured in hair samples, but extraction with tetramethylammonium hydroxide (TMAH) resulted in degradation of Gd-DTPA.

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Acknowledgements

The authors gratefully acknowledge the financial support of the “Deutsche Forschungsgemeinschaft” (DFG) and the land “Rheinland-Pfalz” within the interdisciplinary graduate program “Trace analysis of elemental species: development of methods and applications‘’.

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  1. Institute of Inorganic Chemistry and Analytical Chemistry, Johannes Gutenberg-University of Mainz, Duesbergweg 10-14, 55099, Mainz, Germany

    Valeria Loreti & Jörg Bettmer

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  1. Valeria Loreti
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  2. Jörg Bettmer
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Correspondence to Jörg Bettmer.

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Loreti, V., Bettmer, J. Determination of the MRI contrast agent Gd-DTPA by SEC–ICP–MS. Anal Bioanal Chem 379, 1050–1054 (2004). https://doi.org/10.1007/s00216-004-2700-4

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  • DOI: https://doi.org/10.1007/s00216-004-2700-4

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