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Blunted striatal response to monetary reward anticipation during smoking abstinence predicts lapse during a contingency-managed quit attempt

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Abstract

Rationale

Tobacco smoking is associated with dysregulated reward processing within the striatum, characterized by hypersensitivity to smoking rewards and hyposensitivity to non-smoking rewards. This bias toward smoking reward at the expense of alternative rewards is further exacerbated by deprivation from smoking, which may contribute to difficulty maintaining abstinence during a quit attempt.

Objective

We examined whether abstinence-induced changes in striatal processing of rewards predicted lapse likelihood during a quit attempt supported by contingency management (CM), in which abstinence from smoking was reinforced with money.

Methods

Thirty-six non-treatment-seeking smokers participated in two functional MRI (fMRI) sessions, one following 24-h abstinence and one following smoking as usual. During each scan, participants completed a rewarded guessing task designed to elicit striatal activation in which they could earn smoking and monetary rewards delivered after the scan. Participants then engaged in a 3-week CM-supported quit attempt.

Results

As previously reported, 24-h abstinence was associated with increased striatal activation in anticipation of smoking reward and decreased activation in anticipation of monetary reward. Individuals exhibiting greater decrements in right striatal activation to monetary reward during abstinence (controlling for activation during non-abstinence) were more likely to lapse during CM (p < 0.025), even when controlling for other predictors of lapse outcome (e.g., craving); no association was seen for smoking reward.

Conclusions

These results are consistent with a growing number of studies indicating the specific importance of disrupted striatal processing of non-drug reward in nicotine dependence and highlight the importance of individual differences in abstinence-induced deficits in striatal function for smoking cessation.

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Acknowledgments

This research was supported by NIH grant (DA027441) to ECD. Maggie Sweitzer was supported by NSF IGERT award (0549352) and the Center for the Neural Basis of Cognition.

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC 3527, Durham, NC, USA

    Maggie M. Sweitzer & F. J. McClernon

  2. Department of Human Development and Family Studies, Penn State University, University Park, PA, USA

    Charles F. Geier

  3. Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA

    Rachel Denlinger, Erika E. Forbes & Eric C. Donny

  4. Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Erika E. Forbes & Eric C. Donny

  5. Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA

    Erika E. Forbes

  6. Center for Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA, USA

    Erika E. Forbes & Eric C. Donny

  7. Department of Psychology, Rowan University, Glassboro, NJ, USA

    Bethany R. Raiff

  8. Department of Psychology, University of Florida, Gainesville, FL, USA

    Jesse Dallery

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  1. Maggie M. Sweitzer
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Correspondence to Maggie M. Sweitzer.

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Sweitzer, M.M., Geier, C.F., Denlinger, R. et al. Blunted striatal response to monetary reward anticipation during smoking abstinence predicts lapse during a contingency-managed quit attempt. Psychopharmacology 233, 751–760 (2016). https://doi.org/10.1007/s00213-015-4152-2

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