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Effects of circadian disruption on methamphetamine consumption in methamphetamine-exposed rats

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Abstract

Rationale

A substantial number of clinical studies indicate associations between sleep abnormalities and drug abuse; however, the role played by the circadian system in the development of addiction is largely unknown.

Objective

The aim of this study was to examine the effects of experimentally induced chronic jet lag on methamphetamine consumption in a rat model of methamphetamine drinking.

Methods

Male Sprague–Dawley rats (n = 32) were housed in running wheel cages in a 12:12 h light:dark cycle. One group of rats (n = 16) was given 2 weeks of forced methamphetamine consumption (0.01 % in drinking water; meth pre-exposed) while a second group (n = 16, not pre-exposed) received water only. This was followed by a 2-week abstinence period during which half of the animals from each group were exposed to four consecutive 6-h advancing phase shifts of the light:dark cycle, while the other half remained on the original light:dark cycle. Methamphetamine consumption was assessed in all rats following the deprivation period using a two-bottle choice paradigm.

Results

Methamphetamine consumption was initially lower in methamphetamine pre-exposed versus not pre-exposed rats. However, during the second week following abstinence, consumption was significantly higher in phase-shifted rats of the methamphetamine pre-exposed group compared to all other groups.

Conclusions

These data reveal an effect of circadian rhythm disturbance on methamphetamine consumption and suggest that dysregulation of the circadian system be considered in the etiology of relapse and addiction.

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Acknowledgments

This work was supported by the National Institutes of Health Grant R01 DA024716 (WJL), and through support from the University of Virginia (MM).

Conflict of interest

All authors report no potential conflicts of interest.

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Authors and Affiliations

  1. Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA, 22911, USA

    Susan E. Doyle, Garrett Garber & Wendy J. Lynch

  2. Department of Biology, University of Virginia, Charlottesville, VA, 22904, USA

    Hanting Feng & Michael Menaker

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  1. Susan E. Doyle
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  2. Hanting Feng
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  3. Garrett Garber
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  4. Michael Menaker
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  5. Wendy J. Lynch
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Correspondence to Wendy J. Lynch.

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Doyle, S.E., Feng, H., Garber, G. et al. Effects of circadian disruption on methamphetamine consumption in methamphetamine-exposed rats. Psychopharmacology 232, 2169–2179 (2015). https://doi.org/10.1007/s00213-014-3845-2

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  • DOI: https://doi.org/10.1007/s00213-014-3845-2

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