References
Brinkman SD, Pomara N, Barnett N, Block R, Domino EF, Gershon S (1984) Lithium-induced increases in red blood cell choline and memory performance in Alzheimer’s-type dementia. Biol Psychiatry 19(2):157–164
Caccamo A, Oddo S, Tran LX, LaFerla FM (2007) Lithium reduces tau phosphorylation but not Aβ or working memory deficits in a transgenic model with both plaques and tangles. Am J Pathol 170(5):1669–1675
Engel T, Goni-Oliver P, Lucas JJ, Avila J, Hernandez F (2006) Chronic lithium administration to FTDP-17 tau and GSK-3β overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. J Neurochem 99:1445–1455
Macdonald A, Briggs K, Poppe M, Higgins, Velayudhan L, Lovestone S (2008) A feasibility and tolerability study of lithium in Alzheimer’s disease. Int J Geriatr Psychiatry 23(7):704–711
Nunes PV, Forlenza OV, Gattaz WF (2007) Lithium and risk for Alzheimer’s disease in elderly patients with bipolar disorder. Br J Psychiatry 190:359–360
Terao T, Nakano H, Inoue Y, Okamoto T, Nakamura J, Iwata N (2006) Lithium and dementia: a preliminary study. Prog Neuropsychopharmacol Biol Psychiatry 30:1125–1128
Tsaltas E, Kontis D, Boulougouris V, Papadimitriou (2009) Lithium and cognitive enhancement: leave it or take it? Psychopharmacology 202:457–476
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Pomara, N. Lithium treatment in Alzheimer’s disease does not promote cognitive enhancement, but may exert long-term neuroprotective effects. Psychopharmacology 205, 169–170 (2009). https://doi.org/10.1007/s00213-009-1510-y
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DOI: https://doi.org/10.1007/s00213-009-1510-y