Abstract
Rationale
The majority of studies investigating the cognitive effects of modafinil, a wake-promoting compound, demonstrate some improvements in attention. The potential of the drug to selectively benefit distinct components of attention has yet to be fully explored in healthy adults.
Objective
The present study was conducted to investigate modafinil’s effect on specific cognitive tasks that tax components of attention switching. One required the rapid switching of attention between stimuli, and another contained an embedded working memory component on top of the attentional shift requirements. Additionally, prospective memory was examined, which requires the interruption of an ongoing activity to retrieve and act upon a previously formed intention.
Materials and methods
Healthy non-smoking volunteers, matched on age, intelligence, and baseline cognitive ability, received either a capsule that contained 200 mg modafinil or placebo. Subjective measures of mood and physiological response were taken throughout the experimental session, and the tasks were completed between 2 and 3 h post-dosing.
Results
Two hundred milligrams modafinil improved accuracy without a reaction time trade-off, in both conditions of the attention-shifting task, but only when resources were most challenged. In contrast, the drug afforded no improvement in prospective remembering or in the ongoing task that was interrupted.
Conclusion
Modafinil appears to promote rapid switching of attention in conditions that are most demanding, whilst it offers no benefits in a task that requires unpredictable and infrequent disengagement of attention from an ongoing task in order to act upon an alternative task.
Similar content being viewed by others
Notes
Convention in the PM paradigm separates the setting up of the delayed intention and the practice from the experimental session by a short period of time. Instructions regarding the PM intention are not reiterated on returning 30 min later for the PM test.
Four participants did not complete the switching task; three due to equipment failure and one due to a scheduling error. A separate participant only completed the constant condition. These missing data did not compromise the counter-balancing of drug.
References
Baranski JV, Pigeau R, Dinich P, Jacobs I (2004) Effects of modafinil on cognitive and meta-cognitive performance. Hum Psychopharmacol 19:323–332
Bond A, Lader MH (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47:211–218
Burgess PW, Scott SK, Frith CD (2003) The role of the rostral frontal cortex (area 10) in prospective memory: a lateral versus medial dissociation. Neuropsychologia 41:906–918
Caldwell JA Jr, Caldwell JL, Smythe NK III, Hall KK (2000) A double-blind, placebo controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study. Psychopharmacology 150:272–282
Eysenck MW (1982) Attention and arousal: cognition and performance. Springer, New York
Gilbert SJ, Spengler S, Simons JS, Steele JD, Lawrie SM, Frith CD, Burgess PW (2006) Functional specialization within rostral-prefrontal cortex (area 10): a meta-analysis. J Cogn Neurosci 18:932–948
Hunter MD, Ganesan V, Wilkinson ID, Spence SA (2006) Impact of modafinil on prefrontal executive function in schizophrenia. Am J Psychiatry 163:2184–2186
Loose R, Kaufmann C, Tucha O, Auer DP, Lange KW (2006) Neural Networks of response shifting: influence of task speed and stimulus material. Brain Res 1090:146–155
Marchant NL (2008) Nicotine does not improve frequent shifts of attention. Unpublished thesis data
Marchant NL, Trawley S, Rusted JM (2008) Prospective memory or prospective attention: physiological and pharmacological support for an attentional model. Int J Neuropsychopharmacol 11:401–411
Muller U, Steffenhagen N, Regenthal R, Bublak P (2004) Effects of modafinil on working memory processes in humans. Psychopharmacology 177:161–169
Nelson H (1982) National adult reading test manual. Windsor NFER-Nelson, UK
Okuda J, Fujii T, Ohtake H, Tsukiura T, Yamadori A, Frith CD, Burgess PW (2007) Differential involvement of regions of rostral prefrontal cortex (Brodmann area 10) in time- and event-based prospective memory. Int J Psychophysiol 64:233–246
Randall DC, Shneerson JM, Plaha KK, File SE (2003) Modafinil affects mood, but not cognitive function, in healthy young volunteers. Hum Psychopharmacol 18:163–173
Randall DC, Fleck NL, Shneerson JM, File SE (2004) The cognitive-enhancing properties of modafinil are limited in non-sleep deprived middle-aged volunteers. Pharmacol Biochem Behav 77:547–555
Randall DC, Shneerson JM, File SE (2005a) Cognitive effects of modafinil in student volunteers may depend on IQ. Pharmacol Biochem Behav 82:133–139
Randall DC, Viswanath A, Bharania P, Elsabagh SM, Hartley DE, Shneerson JM, File SE (2005b) Does modafinil enhance cognitive performance in young volunteers who are not sleep deprived? J Clin Psychopharmacol 25:175–179
Ravizza SM, Ivry RB (2001) Comparison of the basal ganglia and cerebellum in shifting attention. J Cogn Neurosci 13:285–297
Rusted JM, Warburton DM (1989) Effects of scopolamine on verbal memory; a retrieval or acquisition deficit? Neuropsychobiology 21:76–83
Rusted JM, Trawley S (2006) Comparable effects of nicotine in smokers and nonsmokers on a prospective memory task. Neuropsychopharmacology 31:1545–1549
Rusted JM, Trawley S, Kettle G, Walker H (2005) Nicotine improves memory for delayed intentions. Psychopharmacology 182:355–365
Rusted JM, Sawyer R, Jones C, Trawley SL, Marchant NL (2008) Positive effects of nicotine on cognition: the deployment of attention for prospective memory. Psychopharmacology (in press)
Rycroft N, Hutton SB, Clowry O, Groomsbridge C, Sierakowski A, Rusted JM (2007) Non-cholinergic modulation of antisaccade performance: a modafinil-nicotine comparison. Psychopharmacology 195:245–253
Saletu M, Anderer P, Semlitsch HV, Saletu-Zyhlarz GM, Mandl M, Zeitlhofer J, Saletu B (2007) Low-resolution brain electromagnetic tomography (LORETA) identifies brain regions linked to psychometric performance under modafinil in narcolepsy. Psychiatry Res 154:69–84
Simons JS, Scholvinck ML, Gilbert SJ, Frith CD, Burgess PW (2006) Differential components of prospective memory? Evidence from fMRI. Neuropsychologia 44:1388–1397
Spence SA, Green RD, Wilkinson ID, Hunter MD (2005) Modafinil modulates anterior cingulate function in chronic schizophrenia. Br J Psychiatry 187:55–61
Sylvester CY, Wager TD, Lacey SC, Hernandez L, Nichols TE, Smith EE, Jonides J (2003) Switching attention and resolving interference: fMRI measures of executive functions. Neuropsychologia 41:357–370
Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ (2003) Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology 165:260–269
Turner DC, Clark L, Dowson J, Robbins TW, Sahakian BJ (2004a) Modafinil improves cognition and response inhibition in adult attention-deficit/hyperactivity disorder. Biol Psychiatry 55:1031–1040
Turner DC, Clark L, Pomarol-Clotet E, McKenna P, Robbins TW, Sahakian BJ (2004b) Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia. Neuropsychopharmacology 29:1363–1373
US Modafinil in Narcolepsy Multicenter Study Group (1998) Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy. Ann Neurol 43:88–97
Walsh JK, Randazzo AC, Stone KL, Schweitzer PK (2004) Modafinil improves alertness, vigilance, and executive function during simulated night shifts. Sleep 27:434–439
Wesensten NJ, Belenky G, Kautz MA, Thorne DR, Reichardt RM, Balkin TJ (2002) Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine. Psychopharmacology 159:238–247
Wesensten NJ, Killgore WDS, Balkin TJ (2005) Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation. J Sleep Res 14:255–266
Acknowledgements
This work was supported by a Sussex University D.Phil. studentship and an Overseas Research Scheme Award to the first author. We would like to thank Sam Hutton and two anonymous reviewers for the helpful advice.
Conflicts of interest
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Marchant, N.L., Kamel, F., Echlin, K. et al. Modafinil improves rapid shifts of attention. Psychopharmacology 202, 487–495 (2009). https://doi.org/10.1007/s00213-008-1395-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00213-008-1395-1