References
Addolorato G, Caputo F, Capristo E, Colombo G, Gessa GL, Gasbarrini G (2000) Ability of baclofen in reducing alcohol craving and intake. II. Preliminary clinical evidence. Alcohol Clin Exp Res 24:67–71
Addolorato G, Caputo F, Capristo E, Domenicali M, Bernardi M, Janiri L, Agabio R, Colombo G, Gessa GL, Gasbarrini G (2002a) Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcohol 37:504–508
Addolorato G, Caputo F, Capristo E, Janiri L, Bernardi M, Agabio R, Colombo G, Gessa GL, Gasbarrini G (2002b) Rapid suppression of alcohol withdrawal syndrome by baclofen. Am J Med 112:226–229
Addolorato G, Leggio L, Abenavoli L, De Lorenzi G, Parente A, Caputo F, Janiri L, Capristo E, Rapaccini GL, Gasbarrini G (2003) Suppression of alcohol delirium tremens by baclofen administration: a case report. Clin Neuropharmacol 26:258–262
Besheer J, Lepoutre V, Hodge CW (2004) GABAb receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice. Psychopharmacology 174:358–366
Colombo G, Agabio R, Carai MAM, Lobina C, Pani M, Reali R, Addolorato G, Gessa GL (2000) Ability of baclofen in reducing alcohol intake and withdrawal severity. I. Preclinical evidence. Alcohol Clin Exp Res 24:58–66
Colombo G, Serra S, Brunetti G, Atzori G, Pani M, Vacca G, Addolorato G, Froestl W, Carai MAM, Gessa GL (2002) The GABA(B) receptor agonists baclofen and CGP 44532 prevent acquisition of alcohol drinking behaviour in alcohol-preferring rats. Alcohol Alcohol 37:499–503
Flannery BA, Garbutt JC, Cody MW, Renn W, Grace K, Osborne M, Crosby K, Morreale M, Trivette A (2004) Baclofen for alcohol dependence: a preliminary open-label study. Alcohol Clin Exp Res (in press)
National Institute on Alcohol Abuse and Alcoholism (2004) Neuroscience research and therapeutic targets. Alcohol Alert 61:1–6
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Addolorato, G., Leggio, L., Abenavoli, L. et al. Tolerance to baclofen’s sedative effect in alcohol-addicted patients: no dissipation after a period of abstinence. Psychopharmacology 178, 351–352 (2005). https://doi.org/10.1007/s00213-004-2014-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00213-004-2014-4