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Effect of glucose on tobacco craving. Is it mediated by tryptophan and serotonin?

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Abstract

Rationale

Oral glucose has been shown to decrease tobacco craving in many but not all previous studies. Glucose ingestion may facilitates entry of tryptophan (TRP), the unique source of brain serotonin, into the brain, glucose’s action seems to be opposite of rapid TRP depletion. Therefore, the aim was to assess the effect of high doses of oral glucose on tobacco craving, withdrawal symptoms, plasma TRP and blood serotonin concentrations in temporarily abstinent smokers.

Methods

Aspartame 0.6 g/200 ml (A, placebo), glucose 32.5 g/200 ml (G32.5) and 75 g/200 ml water (G75) were administered to 12 healthy smokers after an overnight abstinence in a crossover, double blind study. Tobacco craving (short version of the Tobacco Craving Questionnaire, TCQ), withdrawal symptoms, choice reaction time, affect, blood glucose, plasma insulin, nicotine, cotinine, free and total TRP, and blood serotonin concentrations were assessed during a period of 5 h after administration.

Results

Blood glucose and plasma insulin increased after G32.5, G75 and remained unchanged after A. TCQ score increased with A and remained almost unchanged with both doses of glucose (condition×time interaction: P=0.023). Total withdrawal score increased differently according to sex and condition (P<0.05). Motor reaction time increased with A and decreased with glucose (P=0.016). The overall decrease in plasma TRP was 0.31±17, 0.49±0.19 and 1.44±0.24 mg/l with A, G32.5 and G75, respectively (P<0.001). Baseline blood serotonin was lower in women (n=5) than in men; it showed a condition by time (P=0.007) and a condition by time by sex interaction (P=0.023).

Conclusions

Glucose attenuates tobacco craving and withdrawal symptoms in temporarily abstinent smokers. This is accompanied by a decrease in plasma TRP and a sex dependent increase in blood serotonin. Further studies assessing the direct effect of glucose on brain serotonin are needed to ascertain whether a glucose induced reduction in craving is associated with an increase in brain serotonin.

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Acknowledgements

We thank F. Andrieu, S. Montel, M.-F. Le Labrousse and the team of the Centre d’Investigation Clinique, Groupe Hospitalier Universitaire Pitié-Salpêtrière for their highly appreciated clinical and technical assistance, M. Skinner and V. Cornillaut for the careful revision of the manuscript. We are grateful to the Société de Tabacologie for its grant to F. Vorspan.

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Authors and Affiliations

  1. Service de Pharmacologie, Groupe Hospitalier Universitaire Pitié-Salpêtrière, 47-83, Bd de l’Hôpital, 75013, Paris, France

    Ivan Berlin, Florence Vorspan & Dominique Warot

  2. INSERM U 288 Neuropsychopharmacologie, Groupe Hospitalier Universitaire Pitié-Salpêtrière, 47-83, Bd de l’Hôpital, 75013, Paris, France

    Ivan Berlin

  3. Service de Biochimie-Pharmacologie-Hématologie, Centre Hospitalier de Versailles, 177, rue de Versailles, 78157, Le Chesnay, France

    Benjamin Manéglier & Odile Spreux-Varoquaux

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  1. Ivan Berlin
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  5. Odile Spreux-Varoquaux
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Correspondence to Ivan Berlin.

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Berlin, I., Vorspan, F., Warot, D. et al. Effect of glucose on tobacco craving. Is it mediated by tryptophan and serotonin?. Psychopharmacology 178, 27–34 (2005). https://doi.org/10.1007/s00213-004-1980-x

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