Skip to main content
SpringerLink
Log in

A time of promise, a time of promises: ethical issues in advancing psychopharmacological research

  • Introduction
  • Published:
Psychopharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Agency for Health Care Policy and Research (1999) Treatment of depression—newer pharmacotherapies. Summary, Evidence Report/Technology Assessment: Number 7, March. US Government, Rockville, Md. http://www.ahrq.gov/clinic/epcsums/deprsumm.htm

  • Beresin et al. (2003)

  • Biesecker (2003)

  • Brody B (1998) The ethics of biomedical research: an international perspective. Oxford University Press, New York

    Google Scholar 

  • Brody JL, Waldron HB (2000) Ethical issues in research on the treatment of adolescent substance abuse disorders. Addict Behav 25:217–228

    Article  CAS  PubMed  Google Scholar 

  • Bulger RE (1994) Toward a statement of the principles underlying responsible conduct in biomedical research. Acad Med 69:102–107

    CAS  PubMed  Google Scholar 

  • Candilis (2003)

  • Chen (2003)

  • Department of Health and Human Services (1999) Mental health: a report of the surgeon general. US Government, Rockville, Md.

    Google Scholar 

  • Department of Health and Human Services (2003) President’s new freedom commission on mental health, achieving the promise: transforming mental health care in America. US Government: Rockville, Md.

    Google Scholar 

  • Dunn and Jeste (2003)

  • Faden R (1996) The Advisory Committee on Human Radiation Experiments. Reflections on a Presidential Commission. Hastings Cent Rep, 26:5–10

  • Faraone S, Tsuang M, Tsuang D (1999) The future of psychiatric genetics. In: Genetics of mental disorders: a guide for students, clinicians, and researchers. Guilford Press, New York

  • Frank et al. (2003)

  • Geppert CM (2001) The stamp of sorrow: religious and ethical aspects of psychiatric genetics. Doctoral dissertation, Department of Philosophy, International Reform University, Garden Grove

    Google Scholar 

  • Geppert and Bogenschutz (2003)

  • Gluck J, Bell (2003)

  • Gluck J, DiPasquale T, Orlans F (eds) (2002) Applied ethics in animal research: philosophy, regulation, and laboratory applications. Purdue University Press, West Lafayette

    Google Scholar 

  • Hoagwood K, Jensen P, Fisher C (eds) (1996) Ethical issues in mental health research with children and adolescents. Erlbaum, Mahwah

  • Jeste et al. (2003)

  • Kaminsky A, Roberts LW, Brody JL (2003) Understanding the motivations and perspectives expressed by people with schizophrenia regarding participation in mental illness research: a qualitative analysis. Ethics Behav (in press)

    Google Scholar 

  • Kelch RP (2002) Maintaining the public trust in clinical research. N Engl J Med 346:285–287

    Article  PubMed  Google Scholar 

  • Kim (2003)

  • Kleiman M (2003) The “brain disease” idea, drug policy and research ethics. Addiction 98:871–872

    Article  PubMed  Google Scholar 

  • Koski (2003)

  • Levine RJ (1986) Ethics and regulation of clinical research. Urban & Schwartzenberg, Baltimore

  • Mashke (2003)

  • Maubach K (2003) Psychiatric drug discovery and development. Exp Opin Invest Drugs 12:1571–1575

    CAS  Google Scholar 

  • Miskimen et al. (2003)

  • Moreno J (1995) Deciding together: bioethics and moral consensus. Oxford University Press, New York

    Google Scholar 

  • Moreno J (2003) Neuroethics: an agenda for neuroscience and society. Nat Rev Neurosci 4:149–153

    Article  CAS  PubMed  Google Scholar 

  • Murray JL, Lopez AD (eds) (1996) The global burden of disease. A comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020, vol 1. Harvard School of Public Health, Cambridge, Mass.

  • National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1979) The Belmont report: ethical principles and guidelines for the protection of human subjects of research. US Government Printing Office, Washington D.C.

    Google Scholar 

  • National Institutes of Health (2003) http://grants.nih.gov/grants/guide/pa-files/PA-99-079.html

  • Okasha A, Arboleda-Florez J, Sartorius N (eds) (2000) Ethics culture and psychiatry: international perspectives. American Psychiatric Press, Washington, D.C.

    Google Scholar 

  • Pincus H, Lieberman J, Ferris S (1999) Ethics in psychiatric research: a resources manual for human subjects protection. American Psychiatric Press, Washington D.C.

    Google Scholar 

  • Roberts LW (1999) Ethical dimensions of psychiatric research: a constructive, criterion- based approach to protocol preparation. The Research Protocol Ethics Assessment Tool (RePEAT). Biol Psychiatry 46:1106–1119

    CAS  PubMed  Google Scholar 

  • Roberts LW (2000) Evidence-based ethics and informed consent in mental illness research. Arch Gen Psychiatry 57:540–542

    Article  CAS  PubMed  Google Scholar 

  • Roberts LW (2002a) Ethics as endeavor in psychiatry: principles, skills, and knowledge. Psychiatric Times XIX(12).

  • Roberts LW (2002b) Addiction and consent. Am J Bioeth 2:58–60

    Article  Google Scholar 

  • Roberts LW (2000c) Informed consent and the capacity for voluntarism. Am J Psychiatry 159:705–712

    Article  Google Scholar 

  • Roberts LW, Warner TD, Brody JL (2000) Perspectives of patients with schizophrenia and psychiatrists regarding ethically important aspects of research participation. Am J Psychiatry 157:67–74

    CAS  PubMed  Google Scholar 

  • Roberts LW, Geppert C, Brody JL (2001) A framework for considering the ethical aspects of psychiatric research protocols. Commun Psychiatry 42:351–363

    Article  CAS  Google Scholar 

  • Roberts LW, Warner TD, Brody JL, Roberts B, Lauriello J, Lyketsos C (2002) Patient and psychiatrist ratings of hypothetical schizophrenia research protocols: assessment of harm potential and factors influencing participation decisions. Am J Psychiatry 159:573–584

    PubMed  Google Scholar 

  • Roberts et al. (2003a)

  • Roberts LW, Warner TD, Anderson C, Smithpeter M, Rogers M (2003b) Schizophrenia research participants’ responses to protocol safeguards: recruitment, informed consent, and debriefing. Schizophr Res (in press)

  • Roberts LW, Warner TD, Brody JL, Nguyen K, Roberts B (2003c) What is ethically important in clinical research? A preliminary study of attitudes of 73 psychiatric faculty and residents. Schizophr Bull (in press)

  • Rosenstein and Miller (2003)

  • Ruiz P (ed) (2000) Ethnicity and psychopharmacology (Review of Psychiatry Series, vol 19, no. 4); Oldham JO, Riba MB, series eds). American Psychiatric Press, Washington, D.C.

  • Shore D, Hyman S (1999) NIMH symptom challenge and medication discontinuation workshop (editorial). Biol Psychiatry 46:1009–1010

    Google Scholar 

  • Spece R, Shimm D, Buchanan A (1996) Conflicts of interest in clinical practice and research. Oxford University Press, New York

  • Sugarman J, Sulmasy D (eds) (2001) Methods in medical ethics. Georgetown University Press, Washington, D.C.

  • Tallman JF (1999) Neuropsychopharmacology at the new millennium: new industry directions. Neuropsychopharmacology 20:99–105

    Article  CAS  PubMed  Google Scholar 

  • Vitiello (2003)

  • Warner and Gluck (2003)

  • Warner TD, Roberts LW, Nguyen K (2003) Do psychiatrists understand research-related experiences, attitudes, and motivation of schizophrenia study participants? Comp Psychiatry 44:227–233

    Article  Google Scholar 

Download references

Acknowledgements

Dr. Roberts gratefully acknowledges the contribution to this original work made possible through support from three organizations: the National Institute on Mental Health, from the National Institute on Drug Abuse, and from the National Alliance for Research on Schizophrenia and Depression in the form of two Young Investigator Awards (1996–2003). Dr. Roberts wishes to express her appreciation to her co-author, Dr. John Krystal, and the editorial leadership of Psychopharmacology for its commitment to the important area of ethics and psychopharmacology research. She also wishes to thank Dr. Cynthia Geppert and Ms. Halppen Donoghoe for their assistance in the development of this special issue. The author wishes to thank Dr. Samuel Keith for his support for the Empirical Ethics Group and the UNM HSC Institute for Ethics while this work was under early development. The author also thanks Ms. Kristin Edenharder for her assistance in the preparation of this document.

Author information

Authors and Affiliations

  1. Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA

    Laura Weiss Roberts

  2. Department of Psychiatry, Yale University, Yale, Conn., USA

    John Krystal

Authors
  1. Laura Weiss Roberts
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John Krystal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Laura Weiss Roberts.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Roberts, L.W., Krystal, J. A time of promise, a time of promises: ethical issues in advancing psychopharmacological research. Psychopharmacology 171, 1–5 (2003). https://doi.org/10.1007/s00213-003-1704-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00213-003-1704-7

Keywords

Search

Navigation