Abstract
Rationale
Proficiency of information processing is likely to derive from a combination of effective processing of relevant information and efficient inhibition of unwanted or irrelevant material. Compromised inhibitory processes have been associated with the memory deficits in dementia and the elderly. These deficits in inhibition could be directly related to the reduced cholinergic function evident in dementia of the Alzheimer type (DAT). Scopolamine, a cholinergic antagonist, has been associated with disinhibition. Nicotine, a cholinergic agonist, has been associated with enhanced focus and reduced intrusions in both healthy adults and people with dementia.
Objective
This study examines the separate and combined effects of nicotine and scopolamine on inhibitory processes using retrieval induced forgetting (RIF).
Methods
In two studies, minimally deprived smokers received either nicotine or no nicotine, in the second study combined with placebo, 0.3 or 0.5 mg SC scopolamine. All volunteers completed the RIF procedure providing within-subject measures of inhibition in an episodic recall paradigm.
Results
Nicotine did not modulate recall of practised exemplars but it did increase inhibition of unpractised exemplars. Consistent with an effect on encoding, scopolamine reduced recall for all exemplars. Scopolamine did not differentially affect practised or unpractised exemplars, relative to the control words.
Conclusion
Independent of its potential to influence memory at encoding, nicotine can affect task performance by inhibiting unpractised (and by implication, irrelevant) material, thereby reducing interference and benefiting the task in hand. The absence of effects of scopolamine on inhibition in the RIF paradigm argues for a more complex subdivision of "inhibitory" processes, which may be differentially influenced by cholinergic blockade.
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References
Amieva H, Lafont S, Auriacombe S, Rainville C, Orgogozo J-M (1998) Analysis of error types in the trail making test evidences: an inhibitory deficit in dementia of the Alzheimer type. J Clin Exp Neuropsychol 20:280–285
Amieva H, Lafont S, Auriacombe S, Le Carret N, Dartigues J, Orgogozo J, Fabrigoule C (2002) Inhibitory breakdown and dementia of the Alzheimer type: a general phenomenon? J Clin Exp Neuropsychol 24:503–516
Anderson MC, Bell T (2001) Forgetting our facts: the role of inhibitory processes in the loss of propositional knowledge. J Exp Psychol [Gen Sect] 130:544–570
Anderson MC, Bjork R (1994) Mechanisms of inhibition in long term memory: a new taxonomy. In: Dagenbach D, Carr TH (eds) Inhibitory process in attention, memory and language. Academic Press, San Diego
Anderson MC, Spellman BA (1995) On the status of inhibitory mechanisms in cognition: memory retrieval as a model case. Psychol Rev 102:68–100
Anderson MC, Bjork R, Bjork E (1994) Remembering can cause forgetting: retrieval dynamics in long-term memory. J Exp Psychol [Learn Mem Cognit] 20:1063–1087
Anderson MC, Bjork EL, Bjork RA (2000) Retrieval-induced forgetting: evidence for a recall-specific mechanism. Psychonom Bull Rev 7:522–530
Blaxton T, Neely J (1983) Inhibition from semantically related primes: evidence of a category-specific inhibition. Mem Cognit 11:500–510
Brandt J, Rich JB (1995) Memory disorders in the dementias. In: Baddeley AD, Wilson BA, Watts FN (eds) Handbook of memory disorders. Wiley, Chichester, pp 243–270
Dunne MP, Hartley LR (1985) The effects of scopolamine upon verbal memory: evidence for an attentional hypothesis. Acta Psychol 58:205–217
Faust ME, Balota DA, Duchek JM, Gernsbacher MA, Smith S (1997) Inhibitory control during sentence comprehension in individuals with dementia of the Alzheimer type. Brain Language 57:225–253
Fuld P, Katzmann R, Davies P, Terry R (1982) Intrusions as a sign of Alzheimer dementia: chemical and pathological verification. Ann Neurol 11:155–159
Hasher L, Stoltzfus E (1991) Age and inhibition. J Exp Psychol [Learn Mem Cognit] 17:163–169
Heishman SJ, Taylor RC, Henningfield JE (1994) Nicotine and smoking: a review of effects on human performance. Exp Clin Psychopharmacol 2:345–395
Houghton G, Tipper SP (1994) A model of inhibitory mechanisms in selective attention. In: Dagenbach D, Carr TH (eds) Inhibitory processes in attention, memory and language. Academic Press, San Diego, pp 53–112
Jacobs DP, Tröster AI, Butters N (1990) Intrusion errors in the figural memory of patients with Alzheimer's and Huntington's disease. Arch Clin Neuropsychol 5:49–57
Kopelman MD (1986) The cholinergic neurotransmitter system in human memory and dementia: a review. Q J Exp Psychol 38A:535–573
Kopelman MD, Corn TH (1988) Cholinergic "blockade" as a model for cholinergic depletion. Brain 111:1079–1110
Molchan S, Martinez RA, Hill JL, Weingartner HJ, Thompson K, Vitiello B, Sunderland T (1992) Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model. Brain Res Rev 17:215–226
Moulin CJA, Perfect TJ, Conway MA, North AS, Jones RW, James N (2002) Retrieval-induced forgetting in Alzheimer's disease. Neuropsychologia 40:862–867
Neely J (1976) Semantic priming and retrieval from lexical memory: evidence for facilitatory and inhibitory processes. Mem Cognit 4:648–654
Pompeia S, Rusted J, Curran H (2002) Verbal fluency facilitated by the cholinergic blocker, scopolamine. Hum Psychopharmacol Clin Exp 17:51–59
Rodway P, Dienes Z, Schepman A (2000) The effects of cigarette smoking on negative priming. Exp Clin Psychopharmacol 8:104–111
Rusted JM, Eaton-Williams P, Warburton DM (1991) A comparison of the effects of scopolamine and diazepam on working memory. Psychopharmacology 105:442–445
Rusted J, Graupner L, Tennant A et al. (1998) Effortful processing is a requirement for nicotine-induced improvements in memory. Psychopharmacology 138:362–368
Rusted JM, Newhouse PA, Levin EL (2000) Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease. Behav Brain Res 113:121–129
Small B, Herlitz A, Fratiglioni L et al. (1997) Cognitive predictors of incident Alzheimer's disease: a prospective longitudinal study. Neuropsychology 11:413–420
Spieler DH, Balota DA, Faust ME (1996) Stroop performance in healthy younger and older adults and in individuals with dementia of the Alzheimer's type. J Exp Psychol [Hum Percept Perform] 22:461–479
Stroop JR (1935) Studies of interference in serial verbal reaction times. J Exp Psychol 18:643–662
Sunderland T, Tariot PN, Weingartner H, Murphy DL, Newhouse PA, Mueller EA, Cohen RM (1986) Pharmacologic modelling of Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 10:599–610
Sunderland T, Esposito G, Molchan SE, Coppola R, Jones DW, Gorey J, Little JR, Bahro M, Weinberger DR (1995) Differential cholinergic regulation in Alzheimer's patients compared to controls following chronic blockade with scopolamine: a SPECT study. Psychopharmacology 121:2321–2241
Tipper SP (1985) The negative priming effect: inhibitory priming by ignored objects. Q J Exp Psychol 37A:571–590
Tipper SP (1991) Less attentional selectivity as a result of declining inhibition in older adults. Bull Psychon Soc 29:45–47
Tipper SP, Cranston M (1985) Selective attention and priming: Inhibitory and facilitatory effects of ignored primes. Q J Exp Psychol 37A:591–611
Tröster A (1998) Cortical and subcortical influences on clustering and switching in the performance of verbal fluency tasks. Neuropsychologia 36:295–304
Tröster AI, Beatty WW, Staton RD, Rorabaugh AG (1989) Effects of scopolamine on anterograde and remote memory in humans. Psychobiology 17:12–18
Wesnes K, Revell A (1984) The separate and combined effects of scopolamine and nicotine on human information processing. Psychopharmacology 84:5–11
West R, Alain C (2000) Age-related decline in inhibitory control contributes to the increased Stroop effect observed in older adults. Psychophysiology 37:179–189
Zacks R, Hasher L (1994) Directed ignoring: inhibitory regulation of working memory. In: Dagenbach D, Carr TH (eds) Inhibitory processes in attention, memory and language. Academic Press, San Diego
Acknowledgements
This work was completed as part of T.E.'s D Phil thesis, funded by a bursary from Sussex University. Thanks to Pennie Smith for help with recruitment, Corne Kros for medical supervision, H. Val Curran for her input in the early development of this work, and to anonymous reviewers for helpful comments on the manuscript.
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Edginton, T., Rusted, J.M. Separate and combined effects of scopolamine and nicotine on retrieval-induced forgetting. Psychopharmacology 170, 351–357 (2003). https://doi.org/10.1007/s00213-003-1563-2
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DOI: https://doi.org/10.1007/s00213-003-1563-2