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Attentional effects of nicotine and amphetamine in rats at different levels of motivation

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Abstract

Rationale

The effects of drugs on performance of tasks used to assess attention might be confounded with changes in motivation. Few studies have investigated the role of motivational factors in such situations.

Objectives

To determine how changes in motivation for food influence performance of the 5-choice serial reaction time task and whether the effects of nicotine and amphetamine can be explained by motivational changes.

Methods

Male hooded Lister rats were trained to respond to a 1-s light stimulus presented randomly in one of five apertures in order to obtain food reinforcers. For three groups of rats (n=9–10), access to food was restricted to maintain body weights at 80, 90 or 95% of control weights. Saline and nicotine (0.025–0.2 mg/kg) were tested in each group, with and without pre-feeding (5 g). In a second experiment, saline and amphetamine (0.03–0.9 mg/kg s.c.) were tested without pre-feeding.

Results

High levels of motivation for food were associated with increases in anticipatory responses, fewer omission errors, shorter response latencies and completion of more trials, without change in accuracy. Nicotine, but not amphetamine, increased accuracy and the number of trials completed; whereas amphetamine, but not nicotine, increased omission errors. Both drugs decreased anticipatory responding at the largest doses tested. There were few interactions of motivational level with drug effects.

Conclusions

The improvements in performance produced by nicotine did not resemble the effect of increased motivation, but some effects of amphetamine resembled those of reducing the level of motivation for food. Motivational levels did not confound assessments of the attentional effects of the drugs in terms of response accuracy.

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References

  • Baptista T, Teneud L, Hernandez L (1993) Enhancement of amphetamine anorexia after chronic administration of sulpiride in rats. Pharmacol Biochem Behav 45:45–49

    Article  CAS  PubMed  Google Scholar 

  • Bizarro L, Stolerman IP (2001) Different effects of nicotine and motivational level on performance in the rat five-choice serial reaction time task. Behav Pharmacol 12[Suppl 1]:S9

  • Blondel A, Sanger DJ, Moser PC (1999) The effect of repeated nicotine administration on the performance of drug-naive rats in a 5-choice serial reaction time task. Behav Pharmacol 10:665–673

    Article  CAS  PubMed  Google Scholar 

  • Blondel A, Sanger DJ, Moser PC (2000) Characterisation of the effects of nicotine in the five-choice serial reaction time task in rats: antagonist studies. Psychopharmacology 149:293–305

    Article  CAS  PubMed  Google Scholar 

  • Bushnell PJ (1998) Behavioural approaches to the assessment of attention in animals. Psychopharmacology 138:231–259

    Article  CAS  PubMed  Google Scholar 

  • Bushnell PJ, Levin ED, Marrocco RT, Sarter MF, Strupp BJ, Warburton DM (2000) Attention as a target of intoxication: insights and methods from studies of drug abuse. Neurotoxicol Teratol 22:487–502

    Article  CAS  PubMed  Google Scholar 

  • Cabeza de Vaca S, Carr KD (1998) Food restriction enhances the central rewarding effect of abused drugs. J Neurosci 18:7502–7510

    Google Scholar 

  • Campbell BA, Fibiger HC (1971) Potentiation of amphetamine-induced arousal by starvation. Nature 233:424–425

    Article  CAS  PubMed  Google Scholar 

  • Carli M, Samanin R (1992) Serotonin2 receptor agonists and serotonergic anorectic drugs affect rats' performance differently in a five-choice serial reaction time task. Psychopharmacology 106:228–234

    Article  CAS  PubMed  Google Scholar 

  • Clarke PBS (1987) Nicotine and smoking: a perspective from animal studies. Psychopharmacology 92:135–143

    CAS  PubMed  Google Scholar 

  • Clarke PBS, Kumar R (1984) Some effects of nicotine on food and water intake in undeprived rats. Br J Pharmacol 82:233–239

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cole BJ, Robbins TW (1987) Amphetamine impairs the discriminative performance of rats with dorsal noradrenergic bundle lesions on a 5-choice serial reaction time task: new evidence for central dopaminergic-noradrenergic interactions. Psychopharmacology 91:458–466

    Article  CAS  PubMed  Google Scholar 

  • Dews PB, Wenger GR (1977) Rate-dependency of the behavioral actions of amphetamine. In: Thompson T, Dews PB (eds) Advances in behavioral pharmacology. Academic Press, New York, pp 167–227

  • Donny EC, Caggiula AR, Mielke MM, Jacobs KS, Rose C, Sved AF (1998) Acquisition of nicotine self-administration in rats: the effects of dose, feeding schedule, and drug contingency. Psychopharmacology 136:83–90

    Article  CAS  PubMed  Google Scholar 

  • Grilly DM (2000) A verification of psychostimulant-induced improvement in sustained attention in rats: effects of d-amphetamine, nicotine, and pemoline. Exp Clin Psychopharmacology 8:14–21

    Article  CAS  Google Scholar 

  • Grottick AJ, Higgins GA (2000) Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time. Behav Brain Res 117:197–208

    Article  CAS  PubMed  Google Scholar 

  • Grottick AJ, Higgins GA (2002) Assessing a vigilance decrement in aged rats: effects of pre-feeding, task manipulation, and psychostimulants. Psychopharmacology 164:33–41

    Article  CAS  PubMed  Google Scholar 

  • Hahn B, Stolerman IP (2002) Nicotine-induced attentional enhancement in rats: effects of chronic exposure to nicotine. Neuropsychopharmacology 27:712–722

    Article  CAS  PubMed  Google Scholar 

  • Hahn B, Shoaib M, Stolerman IP (2002) Nicotine-induced enhancement of attention in the five-choice serial reaction time task: the influence of task demands. Psychopharmacology 162:129–137

    Article  CAS  PubMed  Google Scholar 

  • Harrison AA, Everitt BJ, Robbins TW (1997) Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms. Psychopharmacology 133:329–342

    Article  CAS  PubMed  Google Scholar 

  • Jones JR, Caul WF, Hill JO (1992) The effects of amphetamine on body weight and energy expenditure. Physiol Behav 51:607–611

    Article  CAS  PubMed  Google Scholar 

  • Kelleher RT, Morse WH (1968) Determinants of the specificity of behavioral effects of drugs. Ergebn Physiol Biol Chemie Exp Pharmakol 60:1–56

    CAS  Google Scholar 

  • Koelega HS (1993) Stimulant drugs and vigilance performance: a review. Psychopharmacology 111:1–16

    Article  CAS  PubMed  Google Scholar 

  • Levin ED, Conners CK, Silva D, Hinton SC, Meck WH, March J, Rose JE (1998) Transdermal nicotine effects on attention. Psychopharmacology 140:135–141

    Article  CAS  PubMed  Google Scholar 

  • Mirza NR, Stolerman IP (1998) Nicotine enhances sustained attention in the rat under specific task conditions. Psychopharmacology 138:266–274

    Article  CAS  PubMed  Google Scholar 

  • Muir JL, Everitt BJ, Robbins TW (1995) Reversal of visual attentional dysfunction following lesions of the cholinergic basal forebrain by physostigmine and nicotine but not by the 5-HT3 receptor antagonist, ondansetron. Psychopharmacology 118:82–92

    Article  CAS  PubMed  Google Scholar 

  • Munster G, Battig K (1975) Nicotine-induced hypophagia and hypodipsia in deprived and in hypothalamically stimulated rats. Psychopharmacology 41:211–217

    Article  CAS  Google Scholar 

  • Niijima A, Miyata G, Sato T, Meguid MM (2001) Hepato-vagal pathway associated with nicotine's anorectic effect in the rat. Auton Neurosci 93:48–55

    Article  CAS  PubMed  Google Scholar 

  • Robbins TW (2002) The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology 163:362–380

    Article  CAS  PubMed  Google Scholar 

  • Spealman RD, Goldberg SR, Gardner ML (1981) Behavioral effects of nicotine: schedule-controlled responding by squirrel monkeys. J Pharmacol Exp Ther 216:484–491

    CAS  PubMed  Google Scholar 

  • Stolerman IP, Mirza NR, Shoaib M (1995) Nicotine psychopharmacology: addiction, cognition and neuroadaptation. Med Res Rev 15:47–72

    Article  CAS  PubMed  Google Scholar 

  • Turchi J, Holley LA, Sarter M (1995) Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats. Psychopharmacology 118:195–205

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank the Medical Research Council for supporting this research with a programme grant.

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Authors and Affiliations

  1. Section of Behavioural Pharmacology, Institute of Psychiatry P049, King's College London, De Crespigny Park, London, SE5 8AF, UK

    L. Bizarro & I. P. Stolerman

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  1. L. Bizarro
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  2. I. P. Stolerman
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Correspondence to I. P. Stolerman.

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Bizarro, L., Stolerman, I.P. Attentional effects of nicotine and amphetamine in rats at different levels of motivation. Psychopharmacology 170, 271–277 (2003). https://doi.org/10.1007/s00213-003-1543-6

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  • DOI: https://doi.org/10.1007/s00213-003-1543-6

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