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Atypical antipsychotics and mood stabilization in bipolar disorder

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Abstract

The available literature on the use of atypical antipsychotics for the treatment of bipolar disorder was reviewed. All uncontrolled and controlled reports were identified through a comprehensive Medline search. Based on the available evidence, olanzapine was found to be the most appropriate atypical antipsychotic agent utilized for the treatment of manic bipolar patients, although there is also preliminary data suggesting the efficacy of risperidone and clozapine. The preliminary data evaluating the efficacy of quetiapine and ziprasidone in bipolar disorder are still very limited. Double-blind controlled studies with atypical antipsychotics in the long-term treatment of bipolar disorder are still largely not available, but will be critical to determine the effectiveness of these agents in the maintenance treatment of bipolar disorder. There are recent uncontrolled suggestions that olanzapine may have beneficial effects in depressed bipolar patients, which deserve further investigation in controlled studies. In conclusion, atypical antipsychotics, due to lower potential for neurotoxicity and preliminary evidence suggesting better efficacy than typical antipsychotics, are increasingly having a more prominent role in the pharmacological management of bipolar patients. Nonetheless, until there is systematic data from long-term controlled follow-up studies on the comparative efficacy of these agents with mood stabilizers, atypical antipsychotics should be cautiously utilized, and preferably in combination with a mood stabilizer for the maintenance phase of treatment.

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References

  • Abou-Saleh MT, Coppen A (1986) Who responds to prophylactic lithium? J Affect Disord 10:115–125

    Article  CAS  PubMed  Google Scholar 

  • Ahmed Z, Anderson IM (2001) Treatment of bipolar affective disorder in clinical practice. J Psychopharmacol 15:55–57

    CAS  PubMed  Google Scholar 

  • Altshuler LL, Post RM, Leverich GS, Mikalauskas K, Rosoff A, Ackerman L (1995) Antidepressant-induced mania and cycle acceleration: a controversy revisited. Am J Psychiatry 152:1130–1138

    CAS  PubMed  Google Scholar 

  • Ananth J, Kenan J (1999) Tardive dyskinesia associated with olanzapine monotherapy. J Clin Psychiatry 60:870

    CAS  PubMed  Google Scholar 

  • Antonacci DJ, Swartz CM (1995) Clozapine treatment of euphoric mania. Ann Clin Psychiatry 7:203–206

    CAS  PubMed  Google Scholar 

  • Aubry J-M, Simon AE, Bertschy G (2000) Possible induction of mania and hypomania by olanzapine or risperidone: a critical review of reported cases. J Clin Psychiatry 61:649–655

    CAS  PubMed  Google Scholar 

  • Banov MD, Zarate CA Jr, Tohen M, Scialabba D, Wines JD Jr, Kolbrener M, Kim JW, Cole JO (1994) Clozapine therapy in refractory affective disorders: polarity predicts response in long-term follow-up. J Clin Psychiatry 55:295–300

    CAS  PubMed  Google Scholar 

  • Barbini B, Scherillo P, Benedetti F, Crespi G, Colombo C, Smeraldi E (1997) Response to clozapine in acute mania is more rapid than that of chlorpromazine. Int Clin Psychopharmacol 12:109–112

    CAS  PubMed  Google Scholar 

  • Barkin JS, Pais VM Jr, Gaffney MF (1997) Induction of mania by risperidone resistant to mood stabilizers. J Clin Psychopharmacol 17:57–58

    Article  CAS  PubMed  Google Scholar 

  • Battegay R, Cotar B, Fleischhauer J, Rauchfleisch U (1977) Results and side effects of treatment with clozapine (leponex R). Comp Psychiatry 18:423–428

    CAS  Google Scholar 

  • Beasley CM Jr, Tollefson G, Tran P, Satterlee W, Sanger T, Hamilton S (1996) Olanzapine versus placebo and haloperidol: acute phase results of the North American double-blind olanzapine trial. Neuropsychopharmacology 14:111–123

    CAS  PubMed  Google Scholar 

  • Benabarre A, Vieta E, Martinez-Aran A, Goikolea JM, Corbella B, Martinez G, Fernandez A, et al (2001) Risperidone as an adjunctive treatment in mixed mania. Bipolar Disord 3:26

    Google Scholar 

  • Benazzi F (1999) Olanzapine-induced psychotic mania in bipolar schizo-affective disorder. Eur Psychiatry 14:410–411

    Article  CAS  PubMed  Google Scholar 

  • Benazzi F (2001) Quetiapine-associated hypomania in a woman with schizoaffective disorder. Can J Psychiatry 46:182–183

    CAS  Google Scholar 

  • Berk M, Ichim L, Brook S (1999) Olanzapine compared to lithium in mania: a double-blind randomized controlled trial. Int Clin Psychopharmacol 14:339–343

    CAS  PubMed  Google Scholar 

  • Bleich A, Brown SL, Kahn R, van Praag HM (1988) The role of serotonin in schizophrenia. Schizophr Bull 14:297–315

    CAS  PubMed  Google Scholar 

  • Brambilla P, Soares JC (2001) The pharmacological treatment of acute mania. In: Dunner DL, Rosenbaum J (eds) Psychiatric clinics of North America: annual of drug therapy, vol 8. Saunders, Philadelphia, pp 155–180

    Google Scholar 

  • Brambilla P, Barale F, Soares JC (2001) Perspectives on the use of anticonvulsants in the treatment of bipolar disorder. Int J Neuropsychopharmacol 4:421–446

    CAS  PubMed  Google Scholar 

  • Brown ES, Nejtek A, Perantie DC, Bodadilla L (2001) Quetiapine in patients with bipolar disorder and cocaine dependence. Bipolar Disord 3:29

    Google Scholar 

  • Bruneau MA, Stip E (1998) Metronome or alternating Pisa syndrome: a form of tardive dystonia under clozapine treatment. Int Clin Psychopharmacol 13:229–32

    CAS  PubMed  Google Scholar 

  • Buzan RD (1996) Risperidone-induced tardive dyskinesia. Am J Psychiatry 153:734–735

    CAS  Google Scholar 

  • Calabrese JR, Gajwani P (2000) Lamotrigine and clozapine for bipolar disorder. Am J Psychiatry 157:1523

    Article  CAS  Google Scholar 

  • Calabrese JR, Meltzer HY, Markovitz PJ (1991) Clozapine prophylaxis in rapid cycling bipolar disorder. J Clin Psychopharmacol 11:396–397

    CAS  PubMed  Google Scholar 

  • Calabrese JR, Kimmel SE, Woyshville MJ, Rapport DJ, Faust CJ, Thompson PA, Meltzer HY (1996) Clozapine for treatment-refractory mania. Am J Psychiatry 153:759–764

    CAS  PubMed  Google Scholar 

  • Calabrese JR, Suppes T, Bowden CL, Sachs GS, Swann AC, McElroy SL, Kusumakar V, Ascher JA, Earl NL, Greene PL, Monaghan ET (2000) A double blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Lamictal 614 Study Group. J Clin Psychiatry 61:841–850

    CAS  PubMed  Google Scholar 

  • Campbell M (1999) Risperidone-induced tardive dyskinesia in first-episode psychotic patients. J Clin Psychopharmacol 19:276–277

    Article  CAS  PubMed  Google Scholar 

  • Carroll NB, Boehm KE, Strickland RT (1999) Chorea and tardive dyskinesia in a patient taking risperidone. J Clin Psychiatry 60:485–487

    CAS  Google Scholar 

  • Catapano-Friedman L (2001) Effectiveness of quetiapine in the management of psychotic depression in an adolescent boy with bipolar disorder, mixed, with psychosis. J Child Adolesc Psychopharmacol 11:205–206

    Article  CAS  PubMed  Google Scholar 

  • Chang KD, Ketter TA (2000) Mood stabilizer augmentation with olanzapine in acutely manic children. J Child Adolesc Psychopharmacol 10:45–49

    CAS  PubMed  Google Scholar 

  • Chouinard G, Jones B, Remington G, Bloom D, Addington D, MacEwan GW, Labelle A, Beauclair L, Arnott W (1993) A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients. J Clin Psychopharmacol 13:25–40

    CAS  PubMed  Google Scholar 

  • Ciapparelli A, Dell'Osso L, Pini S, Chiavacci MC, Fenzi M, Cassano GB (2000) Clozapine for treatment-refractory schizophrenia, schizoaffective disorder, and psychotic bipolar disorder: a 24-month naturalistic study. J Clin Psychiatry 61:329–334

    CAS  PubMed  Google Scholar 

  • Claghorn J, Honigfeld G, Abuzzahab FS Sr, Wang R, Steinbook R, Tuason V, Klerman G (1987) The risks and benefits of clozapine versus chlorpromazine. J Clin Psychopharmacol 7:377–384

    CAS  PubMed  Google Scholar 

  • Claus A, Bollen J, De Cuyper H, Eneman M, Malfroid M, Peuskens J, Heylen S (1992) Risperidone versus haloperidol in the treatment of chronic schizophrenic inpatients: a multicentre double-blind comparative study. Acta Psychiatr Scand 85:295–305

    CAS  PubMed  Google Scholar 

  • Cohen BM, Keck PE, Satlin A, Cole JO (1991) Prevalence and severity of akathisia in patients on clozapine. Biol Psychiatry 29:1215–1219

    CAS  PubMed  Google Scholar 

  • Cole JO, Gardos G, Boling LA, Marby D, Haskell D, Moore P (1992) Early dyskinesia-vulnerability. Psychopharmacology 107:503–510

    CAS  PubMed  Google Scholar 

  • Copolov DL, Link CG, Kowalcyk B (2000) A multicentre, double-blind, randomized comparison of quetiapine (ICI 204,636, 'Seroquel') and haloperidol in schizophrenia. Psychol Med 30:95–105

    Article  CAS  PubMed  Google Scholar 

  • Daniel DG, Zimbroff DL, Potkin SG, Reeves KR, Harrigan EP, Lakshminarayanan M (1999) Ziprasidone 80 mg/day and 160 mg/day in the acute exacerbation of schizophrenia and schizoaffective disorder: a 6-week placebo-controlled trial. Ziprasidone Study Group. Neuropsychopharmacology 20:491–505

    Article  CAS  PubMed  Google Scholar 

  • Dave M (1994) Clozapine-related tardive dyskinesia. Biol Psychiatry 35:886–887

    CAS  PubMed  Google Scholar 

  • Delay J, Deniker P, Harl J (1952) Utilization therapeutique psychiatrique d'une phenothiazine d'action cetrale elective (4560 RP). Ann Med Psychol 110:112–117

    Google Scholar 

  • DelBello MP, Rosenberg HL, Hudepohl AM, Strakowski SM (2001) Quetiapine as adjunctive treatment for adolescent mania. Bipolar Disord 3:33

    Google Scholar 

  • Denicoff KD, Sollinger AB, Frye MA, Ali SO, Smith-Jackson EE, Leverich GS, Post RM (2000) Neuroleptic exposure in bipolar outpatients in a research setting. Comp Psychiatry 41:248–252

    Article  CAS  Google Scholar 

  • Diaz SF (1996) Mania associated with risperidone use. J Clin Psychiatry 57:41–42

    CAS  Google Scholar 

  • Dilsaver SC, Swann AC (1995) Mixed mania: apparent induction by a tricyclic antidepressant in five consecutively treated patients with bipolar depression. Biol Psychiatry 37:60–62

    Article  CAS  PubMed  Google Scholar 

  • Dilsaver SC, Swann AC, Shoaib AM, Bowers TC (1993a) The manic syndrome: factors which may predict a patient's response to lithium, carbamazepine and valproate. J Psychiatry Neurosci 18:61–66

    CAS  PubMed  Google Scholar 

  • Dilsaver SC, Swann AC, Shoaib AM, Bowers TC, Halle MT (1993b) Depressive mania associated with nonresponse to antimanic agents. Am J Psychiatry 150:1548–1551

    CAS  PubMed  Google Scholar 

  • D'Souza R, Kingston C, Scurrah M, Williams J (2001) An open label study of risperidone and serteraline in the treatment of rural patients with bipolar 1 depression. Bipolar Disord 3:34

    Google Scholar 

  • Dunayevich E (2001) Quetiapine in the treatment of mania. Biol Psychiatry 49:109

    Google Scholar 

  • Dunayevich E, Strakowski SM (1999) Olanzapine-induced tardive dystonia. Am J Psychiatry 156:1662

    CAS  Google Scholar 

  • Dunayevich E, Strakowski SM (2000) Quetiapine for treatment-resistant mania. Am J Psychiatry 157:1341

    Article  CAS  Google Scholar 

  • Dwight MM, Keck PE Jr, Stanton SP, Strakowski SM, McElroy SL (1994) Antidepressant activity and mania associated with risperidone treatment of schizoaffective disorder. Lancet 344:554–555

    CAS  PubMed  Google Scholar 

  • Emsley RA, Raniwalla J, Bailey PJ, Jones AM (2000) A comparison of the effects of quetiapine ('seroquel') and haloperidol in schizophrenic patients with a history of and a demonstrated, partial response to conventional antipsychotic treatment. PRIZE Study Group. Int Clin Psychopharmacol 15:121–131

    CAS  PubMed  Google Scholar 

  • Fitz-Gerald MJ, Pinkofsky HB, Brannon G, Dandridge E, Calhoun A (1999) Olanzapine-induced mania. Am J Psychiatry 156:1114

    CAS  Google Scholar 

  • Frankenburg FR (1993) Clozapine and bipolar disorder. J Clin Psychopharmacol 13:289–290

    PubMed  Google Scholar 

  • Frankenburg FR, Zanarini MC (1994) Uses of clozapine in nonschizophrenic patients. Harv Rev Psychiatry 2:142–150

    CAS  PubMed  Google Scholar 

  • Fras I, Leslie F (1995) Clinical experience with risperidone. J Am Acad Child Adolesc Psychiatry 34:833–834

    CAS  Google Scholar 

  • Frazier JA, Meyer MC, Biederman J, Wozniak J, Wilens TE, Spencer TJ, Kim GS, Shapiro S (1999) Risperidone treatment for juvenile bipolar disorder: a retrospective chart review. J Am Acad Child Adolesc Psychiatry 38:960–965

    CAS  PubMed  Google Scholar 

  • Frazier JA, Biederman J, Tohen M, Feldman PD, Jacobs TG, Toma V, Rater MA, Tarazi RA, Kim GS, Gardfield SB, Sohma M, Gonzalez-Heydich J, Risser RC, Nowlin ZM (2001) A prospective open-label treatment trial of olanzapine monotherapy in children and adolescents with bipolar disorder. J Child Adolesc Psychopharmacol 11:239–250

    Article  CAS  PubMed  Google Scholar 

  • Friedman JH (1998) Rapid onset tardive dyskinesia (fly catcher tongue) in a neuroleptically naive patient induced by risperidone. Med Health R I 81:271–272

    CAS  PubMed  Google Scholar 

  • Frye MA, Altshuler LL, Bitran JA (1996) Clozapine in rapid cycling bipolar disorder. J Clin Psychopharmacol 16:87–90

    Article  CAS  PubMed  Google Scholar 

  • Garfinkel PE, Stancer HC, Persad E (1980) A comparison of haloperidol, lithium carbonate and their combination in the treatment of mania. J Affect Disord 2:279–288

    Article  CAS  PubMed  Google Scholar 

  • Gaviria M, Flaherty J, Val E (1982) A comparison of bipolar patients with and without a borderline personality disorder. Psychiatr J Univ Ott 7:190–195

    CAS  PubMed  Google Scholar 

  • Gershon S, Soares JC (1997) Current therapeutic profile of lithium. Arch Gen Psychiatry 54:16–20

    CAS  PubMed  Google Scholar 

  • Ghaemi SN (2001) On defining 'mood stabilizer'. Bipolar Disord 3:154–158

    Article  CAS  PubMed  Google Scholar 

  • Ghaemi SN, Sachs GS (1997) Long-term risperidone treatment in bipolar disorder: 6-month follow up. Int Clin Psychopharmacol 12:333–338

    CAS  PubMed  Google Scholar 

  • Ghaemi SN, Katzow JJ (1999) The use of quetiapine for treatment-resistant bipolar disorder: a case series. Ann Clin Psychiatry 11:137–140

    CAS  PubMed  Google Scholar 

  • Ghaemi SN, Sachs GS, Baldassano CF, Truman CJ (1997) Acute treatment of bipolar disorder with adjunctive risperidone in outpatients. Can J Psychiatry 42:196–199

    CAS  PubMed  Google Scholar 

  • Ghaemi SN, Sachs GS, Chiou AM, Pandurangi AK, Goodwin K (1999) Is bipolar disorder still underdiagnosed? Are antidepressants overutilized? J Affect Disord 52:135–144

    Article  CAS  PubMed  Google Scholar 

  • Ghaemi SN, Boiman EE, Goodwin FK (2000a) Diagnosing bipolar disorder and the effect of antidepressants: a naturalistic study. J Clin Psychiatry 61:804–809

    CAS  PubMed  Google Scholar 

  • Ghaemi SN, Cherry EL, Katzow JA, Goodwin FK (2000b) Does olanzapine have antidepressant properties? A retrospective preliminary study. Bipolar Disord 2:196–199

    Article  CAS  PubMed  Google Scholar 

  • Ghaemi SN, Glodberg JF, Ko JY, Oakley L (2001) Seroquel treatment of rapid-cycling bipolar disorder: an prospective study. Bipolar Disord 3:38

    Google Scholar 

  • Ghelber D, Belmaker RH (1999) Tardive dyskinesia with quetiapine. Am J Psychiatry 156:796–797

    CAS  Google Scholar 

  • Goldberg JF, Harrow M, Leon AC (1996) Lithium treatment of bipolar affective disorders under naturalistic followup conditions. Psychopharmacol Bull 32:47–54

    CAS  PubMed  Google Scholar 

  • Goldstein JM (2000) The new generation of antipsychotic drugs: how atypical are they? Int J Neuropsychopharmacol 3:339–349

    Article  CAS  PubMed  Google Scholar 

  • Goodnick PJ (1995) Risperidone treatment of refractory acute mania. J Clin Psychiatry 56: 431–432

    CAS  PubMed  Google Scholar 

  • Goodwin FK, Zis AP (1979) Lithium in the treatment of mania: comparisons with neuroleptics. Arch Gen Psychiatry 36:840–844

    CAS  PubMed  Google Scholar 

  • Green AI, Tohen M, Patel JK, Banov M, DuRand C, Berman I, Chang H, Zarate C Jr, Posener J, Lee H, Dawson R, Richards C, Cole JO, Schatzberg AF (2000) Clozapine in the treatment of refractory psychotic mania. Am J Psychiatry 157:982–986

    Article  CAS  PubMed  Google Scholar 

  • Guille C, Sachs GS, Ghaemi SN (2000) A naturalistic comparison of clozapine, risperidone, and olanzapine in the treatment of bipolar disorder. J Clin Psychiatry 61:638–642

    CAS  PubMed  Google Scholar 

  • Guscott R, Taylor L (1994) Lithium prophylaxis in recurrent affective illness. Efficacy, effectiveness and efficiency. Br J Psychiatry 164:741–746

    CAS  PubMed  Google Scholar 

  • Haberfellner EM (1997) Tardive dyskinesia during treatment with risperidone. Pharmacopsychiatry 30:271

    CAS  PubMed  Google Scholar 

  • Herran A, Vazquez-Barquero JL (1999) Tardive dyskinesia associated with olanzapine. Ann Intern Med 131:72

    CAS  Google Scholar 

  • Hillert A, Maier W, Wetzel H, Benkert O (1992) Risperidone in the treatment of disorders with a combined psychotic and depressive syndrome—a functional approach. Pharmacopsychiatry 25:213–217

    CAS  PubMed  Google Scholar 

  • Himmelhoch JM, Mulla D, Neil JF, Detre TP, Kupfer DJ (1976) Incidence and significance of mixed affective states in a bipolar population. Arch Gen Psychiatry 33:1062–1066

    CAS  PubMed  Google Scholar 

  • Hong KS, Cheong SS, Woo JM, Kim E (1999) Risperidone-induced tardive dyskinesia. Am J Psychiatry 156:1290

    CAS  Google Scholar 

  • Hunt N, Silverstone T (1991) Tardive dyskinesia in bipolar affective disorder: a catchment area study. Int Clin Psychopharmacol 6:45–50

    CAS  PubMed  Google Scholar 

  • Jacobsen FM (1995) Risperidone in the treatment of affective illness and obsessive-compulsive disorder. J Clin Psychiatry 56:423–429

    CAS  PubMed  Google Scholar 

  • Janicak PG, Newman RH, Davis JM (1992) Advances in the treatment of mania and related disorders: a reappraisal. Psychiatric Annals 22:92–103

    Google Scholar 

  • John V, Rapp M, Pies R (1998) Aggression, agitation, and mania with olanzapine. Can J Psychiatry 43:1054

    CAS  Google Scholar 

  • Johnson G, Gershon S, Burdock EI, Floyd A, Hekimian L (1971) Comparative effects of lithium and chlorpromazine in the treatment of acute manic states. Br J Psychiatry 119:267–276

    CAS  PubMed  Google Scholar 

  • Kane J, Honigfeld G, Singer J, Meltzer H (1988) Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry 45:789–796

    CAS  PubMed  Google Scholar 

  • Kane JM (1999) Tardive dyskinesia in affective disorders. J Clin Psychiatry 60:43–49

    CAS  Google Scholar 

  • Kaplan M (2000) Atypical antipsychotics for treatment of mixed depression and anxiety. J Clin Psychiatry 61:388–389

    CAS  PubMed  Google Scholar 

  • Kapur S (1996) 5-HT2 antagonism and EPS benefits: is there a causal connection? Psychopharmacology 124:35–39

    CAS  PubMed  Google Scholar 

  • Kapur S, Seeman P (2000) Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action. J Psychiatry Neurosci 25:161–166

    CAS  PubMed  Google Scholar 

  • Kapur S, Seeman P (2001) Does fast dissociation from the dopamine D2 receptor explain the action of atypical antipsychotics? A new hypothesis. Am J Psychiatry 158:360–369

    CAS  PubMed  Google Scholar 

  • Kapur S, Remington G, Zipursky RB, Wilson AA, Houle S (1995) The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: a PET study. Life Sci 57:L103–L107

    Article  Google Scholar 

  • Kapur S, Zipursky RB, Remington G, Jones C, DaSilva J, Wilson AA, Houle S (1998) 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. Am J Psychiatry 155:921–928

    CAS  PubMed  Google Scholar 

  • Kapur S, Zipursky RB, Remington G (1999) Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia. Am J Psychiatry 156:286–293

    CAS  PubMed  Google Scholar 

  • Kapur S, Zipursky R, Jones C, Remington G, Houle S (2000a) Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am J Psychiatry 157:514–520

    CAS  PubMed  Google Scholar 

  • Kapur S, Zipursky R, Jones C, Shammi CS, Remington G, Seeman P (2000b) A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy. Arch Gen Psychiatry 57:553–559

    CAS  PubMed  Google Scholar 

  • Karp BI, Goldstein SR, Chen R, Samii A, Bara-Jimenez W, Hallett M (1999) An open trial of clozapine for dystonia. Mov Disord 14:652–657

    Article  CAS  PubMed  Google Scholar 

  • Keck PE Jr (2000) A 3-week, double-blind, randomized trial of ziprasidone in the acute treatment of mania. Int J Neuropsychopharmacol 3:342

    Google Scholar 

  • Keck PE Jr, Wilson DR, Strakowski SM, McElroy SL, Kizer DL, Balistreri TM, Holtman HM, DePriest M (1995) Clinical predictors of acute risperidone response in schizophrenia, schizoaffective disorder, and psychotic mood disorders. J Clin Psychiatry 56:466–470

    PubMed  Google Scholar 

  • Keck PE Jr, McElroy SL, Strakowski SM, Balistreri TM, Kizer DI, West SA (1996) Factors associated with maintenance antipsychotic treatment of patients with bipolar disorder. J Clin Psychiatry 57:147–151

    CAS  PubMed  Google Scholar 

  • Keck PE Jr, Buffenstein A, Ferguson J, Feighner J, Jaffe W, Harrigan EP, Morrissey MR (1998) Ziprasidone 40 and 120 mg/day in the acute exacerbation of schizophrenia and schizoaffective disorder: a 4-week placebo-controlled trial. Psychopharmacology 140:173–184

    CAS  PubMed  Google Scholar 

  • Keck PE Jr, Strakowski SM, McElroy SL (2000) The efficacy of atypical antipsychotics in the treatment of depressive symptoms, hostility, and suicidality in patients with schizophrenia. J Clin Psychiatry 61:4–9

    CAS  Google Scholar 

  • Keck PE Jr, Reeves KR, Harrigan EP (2001) Ziprasidone in the short-term treatment of patients with schizoaffective disorder: results from two double-blind, placebo-controlled, multicenter studies. J Clin Psychopharmacol 21:27–35

    Article  CAS  PubMed  Google Scholar 

  • Ketter TA, Winsberg ME, DeGolia SG, Dunai M, Tate DL, Strong CM (1998) Rapid efficacy of olanzapine augmentation in nonpsychotic bipolar mixed states. J Clin Psychiatry 59:83–85

    CAS  Google Scholar 

  • Ketter TA, Janenawasin S, Wang PW, Schumacher M, Das B, Santosa CM, Mongkolcheep J, Strong CM (2001) Olanzapine yields rapid improvement in diverse syndromal and subsyndromal exacerbations of bipolar disorders. Bipolar Dis 3:44

    Google Scholar 

  • Khouzam HR (2000) Treatment of depressive mood in schizophrenia with the atypical antipsychotic quetiapine. Depress Anxiety 11:80–82

    Article  CAS  PubMed  Google Scholar 

  • Khouzam HR, El-Gabalawi F (2000) Treatment of bipolar I disorder in an adolescent with olanzapine. J Child Adolesc Psychopharmacol 10:147–151

    CAS  PubMed  Google Scholar 

  • Koek RJ, Kessler CC (1996) Probable induction of mania by risperidone. J Clin Psychiatry 57:174–175

    CAS  Google Scholar 

  • Krakowski M, Czobor P, Volavka J (1997) Effect of neuroleptic treatment on depressive symptoms in acute schizophrenic episodes. Psychiatry Res 71:19–26

    Article  CAS  PubMed  Google Scholar 

  • Kukopulos A, Reginaldi D, Laddomada P, Floris G, Serra G, Tondo L (1980) Course of the manic-depressive cycle and changes caused by treatment. Pharmakopsychiatr Neuropsychopharmakol 13:156–167

    CAS  PubMed  Google Scholar 

  • Kukopulos A, Caliari B, Tundo A, Minnai G, Floris G, Reginaldi D, Tondo L (1983) Rapid cyclers, temperament, and antidepressants. Comp Psychiatry 24:249–258

    CAS  Google Scholar 

  • Landry P, Cournoyer J (1998) Acute dystonia with olanzapine. J Clin Psychiatry 59:384

    CAS  PubMed  Google Scholar 

  • Leppig M, Bosch B, Naber D, Hippius H (1989) Clozapine in the treatment of 121 out-patients. Psychopharmacology 99:S77–S79

    PubMed  Google Scholar 

  • Leucht S, Pitschel-Walz G, Abraham D, Kissling W (1999) Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials. Schizophr Res 35:51–68

    CAS  PubMed  Google Scholar 

  • Levine J, Chengappa R, Brar JS et al (2000) Psychotropic drug prescription patterns among patients with bipolar I disorder. Bipolar Disord 2:120–130

    Article  CAS  PubMed  Google Scholar 

  • Leysen JE, Janssen PM, Schotte A, Luyten WH, Megens AA (1993) Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors. Psychopharmacology 112:S40–S54

    Google Scholar 

  • Licht RW, Bysted M, Christensen H (2001) Fixed-dosed risperidone in mania: an open experimental trial. Int Clin Psychopharmacol 16:103–110

    CAS  PubMed  Google Scholar 

  • Lindenmayer JP, Klebanov R (1998) Olanzapine-induced manic-like syndrome. J Clin Psychiatry 59:318–319

    CAS  PubMed  Google Scholar 

  • Lykouras L, Gournellis R, Angelopoulos E (2001) Manic symptoms induced by olanzapine. Eur Neuropsychopharmacol 11:97–98

    CAS  PubMed  Google Scholar 

  • Mahmood T, Devlin M, Silverstone T (1997) Clozapine in the management of bipolar and schizoaffective manic episodes resistant to standard treatment. Aust N Z J Psychiatry 31:424–426

    CAS  PubMed  Google Scholar 

  • Masi G, Milone A (1998) Clozapine treatment in an adolescent with bipolar disorder. Panminerva Med 40:254–257

    CAS  PubMed  Google Scholar 

  • McElroy SL, Dessain EC, Pope HG Jr, Cole JO, Keck PE Jr, Frankenberg FR, Aizley HG, O'Brien S (1991) Clozapine in the treatment of psychotic mood disorders, schizoaffective disorder, and schizophrenia. J Clin Psychiatry 52:411–414

    CAS  PubMed  Google Scholar 

  • McElroy SL, Keck PE Jr, Pope HG Jr, Hudson JI, Faedda GL, Swann AC (1992) Clinical and research implications of the diagnosis of dysphoric or mixed mania or hypomania. Am J Psychiatry 149:1633–1644

    CAS  PubMed  Google Scholar 

  • McElroy SL, Frye M, Denicoff K, Altshuler L, Nolen W, Kupka R, Suppes T, Keck PE Jr, Leverich GS, Kmetz GF, Post RM (1998) Olanzapine in treatment-resistant bipolar disorder. J Affect Disord 49:119–122

    CAS  PubMed  Google Scholar 

  • McIntyre R, Young LT, Hasey G, Patelis-Siotis I, Jones BD (1997) Risperidone treatment of bipolar disorder. Can J Psychiatry 42:88–90

    CAS  Google Scholar 

  • Meehan K, Zhang F, David S, Tohen M, Janicak P, Small J, Koch K, Rizk R, Walker D, Tran P, Breier A (2001) A double-blind, randomized comparison of the efficacy and safety of intramuscular injections of olanzapine, lorazepam, or placebo in treating acutely agitated patients diagnosed with bipolar mania. J Clin Psychopharmacol 21:389–397

    Article  CAS  PubMed  Google Scholar 

  • Melone M, Vitellaro-Zuccarello L, Vallejo-Illarraamendi A, Perez-Samartin A, Matute C, Cozzi A, Pellegrini-Giampietro DE, Rothstein JD, Conti F (2001) The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine. Mol Psychiatry 6:380–386

    Article  CAS  PubMed  Google Scholar 

  • Meltzer HY, Matsubara S, Lee JC (1989a) Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther 251:238–246

    CAS  PubMed  Google Scholar 

  • Meltzer HY, Matsubara S, Lee JC (1989b) The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs. Psychopharmacol Bull 25:390–392

    CAS  PubMed  Google Scholar 

  • Miller AL, Dassori A, Ereshefsky L, Crismon L (2001) Recent issues and development in antipsychotic use. In: Dunner Dl, Rosenbaum JF (eds) The psychiatric clinics of North America. Annual of drug therapy, vol. 8. Saunders, Philadelphia, pp 209–235

  • Miller CH, Mohr F, Umbricht D, Woerner M, Fleischhacker WW, Lieberman JA (1998) The prevalence of acute extrapyramidal signs and symptoms in patients treated with clozapine, risperidone, and conventional antipsychotics. J Clin Psychiatry 59:69–75

    Google Scholar 

  • Molho ES, Factor SA (1999) Possible tardive dystonia resulting from clozapine therapy. Mov Disord 14:873–874

    Article  CAS  PubMed  Google Scholar 

  • Mukherjee S, Rosen AM, Caracci G, Shukla S (1986) Persistent tardive dyskinesia in bipolar patients. Arch Gen Psychiatry 43:342–346

    CAS  PubMed  Google Scholar 

  • Muller-Siecheneder F, Muller MJ, Hillert A, Szegedi A, Wetzel H, Benkert O (1998) Risperidone versus haloperidol and amitriptyline in the treatment of patients with a combined psychotic and depressive syndrome. J Clin Psychopharmacol 18:111–120

    Article  CAS  PubMed  Google Scholar 

  • Naber D, Holzbach R, Perro C, Hippius H (1992) Clinical management of clozapine patients in relation to efficacy and side-effects. Br J Psychiatry Suppl 32:54–59

    Google Scholar 

  • Narendran R, Young C, Valenti AM, Pristach CA, Pato MT, Grace JJ (2001) Olanzapine therapy in treatment-resistant psychotic mood disorders: a long-term follow-up study. J Clin Psychiatry 62:509–516

    CAS  PubMed  Google Scholar 

  • Nasrallah HA, Churchill CM, Hamdan-Allan GA (1988) Higher frequency of neuroleptic-induced dystonia in mania than in schizophrenia. Am J Psychiatry 145:1455–1456

    CAS  PubMed  Google Scholar 

  • Pickar D, Owen RR, Litman RE, Konicki E, Gutierrez R, Rapaport MH (1992) Clinical and biologic response to clozapine in patients with schizophrenia. Crossover comparison with fluphenazine. Arch Gen Psychiatry 49:345–353

    CAS  PubMed  Google Scholar 

  • Platman SR (1970) A comparison of lithium carbonate and chlorpromazine in mania. Am J Psychiatry 127:351–353

    CAS  PubMed  Google Scholar 

  • Pozo P, Alcantara AG (1998) Mania-like syndrome in a patient with chronic schizophrenia during olanzapine treatment. J Psychiatry Neurosci 23:309–310

    CAS  PubMed  Google Scholar 

  • Price CJ, Pitman QJ (2001) Dopamine D4 receptor activation inhibits presynaptically glutamatergic neurotransmission in the rat supraoptic nucleus. J Neurophysiol 86:1149–1155

    CAS  PubMed  Google Scholar 

  • Price LH, Heninger GR (1994) Lithium in the treatment of mood disorders. N Engl J Med 331:591–598

    Article  CAS  PubMed  Google Scholar 

  • Prien RF, Caffey EM Jr, Klett CJ (1972) Comparison of lithium carbonate and chlorpromazine in the treatment of mania. Report of the Veterans Administration and National Institute of Mental Health Collaborative Study Group. Arch Gen Psychiatry 26:146–153

    CAS  PubMed  Google Scholar 

  • Privitera MR, Lamberti JS, Maharaj K (1993) Clozapine in a bipolar depressed patient. Am J Psychiatry 150:986

    CAS  Google Scholar 

  • Puri BK, Taylor DG, Alcock ME (1995) Low-dose maintenance clozapine treatment in the prophylaxis of bipolar affective disorder. Br J Clin Pract 49:333–334

    CAS  PubMed  Google Scholar 

  • Ranjan R, Meltzer HY (1996) Acute and long-term effectiveness of clozapine in treatment-resistant psychotic depression. Biol Psychiatry 40:253–258

    Article  CAS  PubMed  Google Scholar 

  • Ravindran AV, Jones BW, al-Zaid K, Lapierre YD (1997) Effective treatment of mania with olanzapine: 2 case reports. J Psychiatry Neurosci 22:345–346

    CAS  PubMed  Google Scholar 

  • Reeves RR, McBride WA, Brannon GE (1998) Olanzapine-induced mania. J Am Osteopath Assoc 98:549–550

    CAS  PubMed  Google Scholar 

  • Reinares M, Martinez-Aran A, Colom F, Benabarre A, Salamero M, Vieta E (2000) Long-term effects of the treatment with risperidone versus conventional neuroleptics on the neuropsychological performance of euthymic bipolar patients. Actas Esp Psiquiatr 28:231–238

    CAS  PubMed  Google Scholar 

  • Remington G, Kapur S (2000) Atypical antipsychotics: are some more atypical than others? Psychopharmacology 148:3–15

    CAS  PubMed  Google Scholar 

  • Remington G, Kapur S, Zipursky R (1998) The relationship between risperidone plasma levels and dopamine D2 occupancy: a positron emission tomographic study. J Clin Psychopharmacol 18:82–83

    Article  CAS  PubMed  Google Scholar 

  • Roose K, Gelders Y, Heylen S (1988) Risperidone (R64 766) in psychotic patients. A first clinical therapeutic exploration. Acta Psychiatr Belg 88:233–241

    CAS  PubMed  Google Scholar 

  • Rothschild AJ, Bates KS, Boehringer KL, Syed A (1999) Olanzapine response in psychotic depression. J Clin Psychiatry 60:116–118

    CAS  PubMed  Google Scholar 

  • Sachs GS, Printz DJ, Kahn DA, Carpenter D, Docherty JP (2000) The expert consensus guideline series: medication treatment of bipolar disorder 2000. Postgrad Med Apr Spec No:1–104

    Google Scholar 

  • Sachs GS, Ghaemi SN, Grossman F, Bowden CL (2001) Risperidone plus mood stabilizer versus placebo plus mood stabilizer for acute mania of bipolar disorder: a double-blind comparison of efficacy and safety. Bipolar Disord 3:53

    PubMed  Google Scholar 

  • Sajatovic M, DiGiovanni SK, Bastani B, Hattab H, Ramirez LF (1996) Risperidone therapy in treatment refractory acute bipolar and schizoaffective mania. Psychopharmacol Bull 32:55–61

    CAS  PubMed  Google Scholar 

  • Sajatovic M, Brescan DW, Perez DE, DiGiovanni SK, Hattab H, Ray JB, Bingham CR (2001) Quetiapine alone and added to a mood stabilizer for serious mood disorders. J Clin Psychiatry 62:728–732

    CAS  PubMed  Google Scholar 

  • Sanger TM, Grundy SL, Gibson PJ, Namjoshi MA, Greaney MG, Tohen MF (2001) Long-term olanzapine therapy in the treatment of bipolar I disorder: an open-label continuation phase study. J Clin Psychiatry 62:273–281

    CAS  PubMed  Google Scholar 

  • Schaffer CB, Schaffer LC (1996) The use of risperidone in the treatment of bipolar disorder. J Clin Psychiatry 57:136

    CAS  Google Scholar 

  • Schaller JL, Behar D (1999) Quetiapine for refractory mania in a child. J Am Acad Child Adolesc Psychiatry 38:498–499

    CAS  PubMed  Google Scholar 

  • Schnierow BJ, Graeber DA (1996) Manic symptoms associated with initiation of risperidone. Am J Psychiatry 153:1235–1236

    CAS  PubMed  Google Scholar 

  • Schou M (1999) Perspectives on lithium treatment of bipolar disorder: action, efficacy, effect on suicidal behavior. Bipolar Disord 1:5–9

    CAS  PubMed  Google Scholar 

  • Secunda SK, Katz MM, Swann A, Koslow SH, Maas JW, Chuang S, Croughan J (1985) Mania. Diagnosis, state measurement and prediction of treatment response. J Affect Disord 8:113–121

    Article  CAS  PubMed  Google Scholar 

  • Seeman P, Tallerico T (1999) Rapid release of antipsychotic drugs from dopamine D2 receptors: an explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine. Am J Psychiatry 156:876–884

    CAS  PubMed  Google Scholar 

  • Segal J, Berk M, Brook S (1998) Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial. Clin Neuropharmacol 21:176–180

    CAS  PubMed  Google Scholar 

  • Sernyak MJ, Griffin RA, Johnson RM, Pearsall HR, Wexler BE, Woods SW (1994) Neuroleptic exposure following inpatient treatment of acute mania with lithium and neuroleptic. Am J Psychiatry 151:133–135

    CAS  PubMed  Google Scholar 

  • Sernyak MJ, Godleski LS, Griffin RA, Mazure CM, Woods SW (1997) Chronic neuroleptic exposure in bipolar outpatients. J Clin Psychiatry 58:193–195

    CAS  PubMed  Google Scholar 

  • Sharma V, Pistor L (1999) Treatment of bipolar mixed state with olanzapine. J Psychiatry Neurosci 24:40–44

    Google Scholar 

  • Shopsin B, Gershon S, Thompson H, Collins P (1975) Psychoactive drugs in mania. A controlled comparison of lithium carbonate, chlorpromazine, and haloperidol. Arch Gen Psychiatry 32:34–42

    CAS  PubMed  Google Scholar 

  • Singh AN, Catalan J (1994) Risperidone in HIV-related manic psychosis. Lancet 344:1029–1030

    CAS  Google Scholar 

  • Singh AN, Golledge H, Catalan J (1997) Treatment of HIV-related psychotic disorders with risperidone: a series of 21 cases. J Psychosom Res 42:489–493

    Google Scholar 

  • Soares JC (2000) Recent advances in the treatment of bipolar mania, depression, mixed states, and rapid cycling. Int Clin Psychopharmacol 15:183–196

    CAS  PubMed  Google Scholar 

  • Soares JC, Gershon S (1998) The lithium ion: a foundation for psychopharmacological specificity. Neuropsychopharmacology 19:167–182

    Article  CAS  PubMed  Google Scholar 

  • Soares JC, Mallinger AG, Gershon S (1997) The role of antipsychotic agents in the treatment of bipolar disorder patients. Int Clin Psychopharmacol 12:65–76

    CAS  PubMed  Google Scholar 

  • Soares JC, Barwell M, Mallinger AG, Kupfer DJ, Frank E (1999) Adjunctive antipsychotic use in bipolar patients: an open 6-month prospective study following an acute episode. J Affect Disord 56:1–8

    Article  CAS  PubMed  Google Scholar 

  • Soutullo CA, Sorter MT, Foster KD, McElroy SL, Keck PE (1999) Olanzapine in the treatment of adolescent acute mania: a report of seven cases. J Affect Disord 53:279–283

    Article  CAS  PubMed  Google Scholar 

  • Spring G, Schweid D, Gray C, Steinberg J, Horwitz M (1970) A double-blind comparison of lithium and chlorpromazine in the treatment of manic states. Am J Psychiatry 126:1306–1310

    CAS  PubMed  Google Scholar 

  • Suppes T, Phillips KA, Judd CR (1994) Clozapine treatment of nonpsychotic rapid cycling bipolar disorder: a report of three cases. Biol Psychiatry 36:338–340

    CAS  PubMed  Google Scholar 

  • Suppes T, Webb A, Paul B, Carmody T, Kraemer H, Rush AJ (1999) Clinical outcome in a randomized 1-year trial of clozapine versus treatment as usual for patients with treatment-resistant illness and a history of mania. Am J Psychiatry 156:1164–1169

    CAS  PubMed  Google Scholar 

  • Swann AC, Secunda SK, Katz MM, Koslow SH, Maas JW, Chang S, Robins E (1986) Lithium treatment of mania: clinical characteristics, specificity of symptom change, and outcome. Psychiatry Res 18:127–141

    Article  CAS  PubMed  Google Scholar 

  • Takahashi R, Sakuma A, Itoh K, Itoh H, Kurihara M (1975) Comparison of efficacy of lithium carbonate and chlorpromazine in mania. Report of collaborative study group on treatment of mania in Japan. Arch Gen Psychiatry 32:1310–1318

    CAS  PubMed  Google Scholar 

  • Tascedda F, Blom JM, Brunello N, Zolin K, Gennarelli M, Colzi A, Bravi D, Carra S, Racagni G, Riva MA (2001) Modulation of glutamate receptors in response to the novel antipsychotic olanzapine in rats. Biol Psychiatry 15:117–122

    Article  Google Scholar 

  • Tohen M, Waternaux CM, Tsuang MT (1990) Outcome in mania. A 4-year prospective follow-up of 75 patients utilizing survival analysis. Arch Gen Psychiatry 47:1106–1111

    CAS  PubMed  Google Scholar 

  • Tohen M, Zarate CA Jr, Centorrino F, Hegarty JI, Froeschl M, Zarate SB (1996) Risperidone in the treatment of mania. J Clin Psychiatry 57:249–253

    CAS  PubMed  Google Scholar 

  • Tohen M, Sanger TM, McElroy SL, Tollefson GD, Chengappa KN, Daniel DG, Petty F, Centorrino F, Wang R, Grundy SL, Greaney MG, Jacobs TG, David SR, Toma V (1999) Olanzapine versus placebo in the treatment of acute mania. Olanzapine HGEH Study Group. Am J Psychiatry 156:702–709

    CAS  PubMed  Google Scholar 

  • Tohen M, Jacobs TG, Grundy SL, McElroy SL, Banov MC, Janicak PG, Sanger T, Risser R, Zhang F, Toma V, Francis J, Tollefson GD, Breier A (2000) Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group. Arch Gen Psychiatry 57:841–849

    CAS  PubMed  Google Scholar 

  • Tohen M, Baker RW, Milton DR, Risser RC, Gilmore JA, Davis AR, Richey AL (2001a) Olanzapine versus divalproex sodium for the treatment of acute mania. Bipolar Disord 3:60

    Google Scholar 

  • Tohen M, Zhang F, Feldman PD, Evans AR, Breier A (2001b) Olanzapine versus haloperidol in the treatment of acute mania. Bipolar Disord 3:61

    Google Scholar 

  • Tohen M, Jacobs TG, Timpe TM, Risser RC, Keeter EL, Chengappa KNR, Suppes TR, Feldman PD, Breier A (2001c) Efficacy of olanzapine combined with valproate or lithium in the treatment of bipolar disorder. Biol Psychiatry 49:110–111

    Article  PubMed  Google Scholar 

  • Tollefson GD, Beasley CM Jr, Tamura RN, Tran PV, Potvin JH (1997a) Blind, controlled, long-term study of the comparative incidence of treatment-emergent tardive dyskinesia with olanzapine or haloperidol. Am J Psychiatry 154:1248–1254

    CAS  PubMed  Google Scholar 

  • Tollefson GD, Beasley CM Jr, Tran PV, Street JS, Krueger JA, Tamura RN, Graffeo KA, Thieme ME (1997b) Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: results of an international collaborative trial. Am J Psychiatry 154:457–465

    CAS  PubMed  Google Scholar 

  • Tollefson GD, Sanger TM, Lu Y, Thieme ME (1998) Depressive signs and symptoms in schizophrenia: a prospective blinded trial of olanzapine and haloperidol. Arch Gen Psychiatry 55:250–258

    CAS  PubMed  Google Scholar 

  • Tollefson GD, Andersen SW, Tran PV (1999) The course of depressive symptoms in predicting relapse in schizophrenia: a double-blind, randomized comparison of olanzapine and risperidone. Biol Psychiatry 46:365–373

    Article  CAS  PubMed  Google Scholar 

  • Tran PV, Dellva MA, Tollefson GD, Beasley CM Jr, Potvin JH, Kiesler GM (1997) Extrapyramidal symptoms and tolerability of olanzapine versus haloperidol in the acute treatment of schizophrenia. J Clin Psychiatry 58:205–211

    CAS  PubMed  Google Scholar 

  • Vercueil L, Foucher J (1999) Risperidone-induced tardive dystonia and psychosis. Lancet 353:981

    Article  CAS  Google Scholar 

  • Verdoux H, Gonzales B, Takei N, Bourgeois M (1996) A survey of prescribing practice of antipsychotic maintenance treatment for manic-depressive outpatients. J Affect Disord 38:81–87

    Article  CAS  PubMed  Google Scholar 

  • Vieta E, Gasto C, Colom F, Martinez A, Otero A, Vallejo J (1998) Treatment of refractory rapid cycling bipolar disorder with risperidone. J Clin Psychopharmacol 18:172–174

    Article  CAS  PubMed  Google Scholar 

  • Vieta E, Herraiz M, Fernandez A, Gasto C, Benabarre A, Martinez-Aran A, Reinares M (2001a) Efficacy and safety of risperidone in the treatment of schizoaffective disorder: initial results from a large, multicenter surveillance study. Group for the study of risperidone in affective disorders (GSRAD) J Clin Psychiatry 62:623–630

    Google Scholar 

  • Vieta E, Reinares M, Corbella B, Benabarre A, Gilaberte I, Colom F, Martinez-Aran A, Gasto C, Tohen M (2001b) Olanzapine as long-term adjunctive therapy in treatment-resistant bipolar disorder. J Clin Psychopharmacol 21:469–473

    Article  CAS  PubMed  Google Scholar 

  • Wehr T, Goodwin FK (1979) Tricyclics modulate frequency of mood cycles. Chronobiologia 6:377–385

    CAS  PubMed  Google Scholar 

  • Weisler RH, Ahearn EP, Davidson JR, Wallace CD (1997) Adjunctive use of olanzapine in mood disorders: five case reports. Ann Clin Psychiatry 9:259–262

    CAS  PubMed  Google Scholar 

  • Williamson DJ, Andersen SW, Van Campen LE, Sam LM, Sanger TM, Tohen M, Tollefson GD (2001) A double blind study of olanzapine-fluoxetine combination for treatment of psychotic major depression. Bipolar Psychiatry 49:104

    Google Scholar 

  • Yatham LN, group atR-C-s (2001) Risperidone and mood stabilizer combination in acute and continuation treatment of mania. Bipolar Disord 3:63

    PubMed  Google Scholar 

  • Zarate CA Jr, Tohen M (2000) Antipsychotic drug treatment in first-episode mania: a 6-month longitudinal study. J Clin Psychiatry 61:33–38

    Google Scholar 

  • Zarate CA Jr, Tohen M, Baldessarini RJ (1995a) Clozapine in severe mood disorders. J Clin Psychiatry 56:411–417

    PubMed  Google Scholar 

  • Zarate CA Jr, Tohen M, Banov MD, Weiss MK, Cole JO (1995b) Is clozapine a mood stabilizer? J Clin Psychiatry 56:108–112

    PubMed  Google Scholar 

  • Zarate CA Jr, Narendran R, Tohen M, Greaney JJ, Berman A, Pike S, Madrid A (1998) Clinical predictors of acute response with olanzapine in psychotic mood disorders. J Clin Psychiatry 59:24–28

    CAS  Google Scholar 

  • Zarate CA Jr, Rothschild A, Fletcher KE, Madrid A, Zapatel J (2000) Clinical predictors of acute response with quetiapine in psychotic mood disorders. J Clin Psychiatry 61:185–189

    CAS  PubMed  Google Scholar 

  • Zolezzi M, Badr MG (1999) Risperidone-induced mania. Ann Pharmacother 33:380–381

    CAS  PubMed  Google Scholar 

  • Zullino D, Baumann P (1999) Olanzapine for mixed episodes of bipolar disorder. J Psychopharmacol 13:198

    CAS  Google Scholar 

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Acknowledgements

This study was supported by grants MH 01736, MH 29618, and MH 30915 from the National Institute of Mental Health, the Theodore and Vada Stanley Foundation, NARSAD, and by a fellowship from the University of Pavia to Dr. Paolo Brambilla. Dr. Soares was the 1999–2001 Selo NARSAD Investigator.

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  1. Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA

    Paolo Brambilla & Jair C. Soares

  2. Department of Psychiatry, IRCCS S. Matteo, University of Pavia School of Medicine, Pavia, Italy

    Francesco Barale

  3. Advanced Biotechnology Center, University of Genova, Genova, Italy

    Paolo Brambilla

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  1. Paolo Brambilla
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  2. Francesco Barale
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Brambilla, P., Barale, F. & Soares, J.C. Atypical antipsychotics and mood stabilization in bipolar disorder. Psychopharmacology 166, 315–332 (2003). https://doi.org/10.1007/s00213-002-1322-9

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