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Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes

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Abstract

To examine the differences between spontaneous and streptozotocin (STZ)-induced diabetes, four parallel studies were performed; three studies of diabetes-prone BB (BBDP/Wor) rats maintained for 8, 16, and 32 weeks and one study of STZ-injected diabetes-resistant BB (BBDR/Wor) rats maintained for 32 weeks. Each diabetic study has three groups of rats: a control group; a euglycemic group, which received sufficient amounts of insulin; and a hyperglycemic group, which received a suboptimal dose of insulin. The extent of tissue weight changes was generally shown to be less dramatic in the euglycemic diabetic than in the hyperglycemic diabetic rats. STZ-induced diabetes increased the bladder weight more dramatically (up to 3-fold) than did spontaneous diabetes (up to 2-fold). Furthermore, a significant decrease in the size of the adrenal gland (20%) and testis (10%) is observed only with spontaneous diabetes, whereas a significant decrease in the size of the ventral prostate (30%) is observed only with STZ-induced diabetes, although the serum testosterone levels are similar in both groups. Our data demonstrate that there are differences in the effect of insulin treatment on the tissue size of the genitourinary tract between spontaneously developed and streptozotocin-induced diabetes in BB rats.

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Acknowledgements

This study was supported in part by NIH grants DK 38311 and DK 42530. All of the animal studies were approved by Yale Animal Care and Use Committee, Yale University.

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Authors and Affiliations

  1. Section of Urology, Yale University School of Medicine, P.O. Box 208041, New Haven, CT, 06520, USA

    Makoto Yono, Mehdi Pouresmail, Robert M. Weiss & Jamshid Latifpour

  2. Department of Urology, Kumamoto University School of Medicine, Kumamoto, Japan

    Wataru Takahashi

  3. Biomedical Research Models Inc., Worcester, MA, 01606, USA

    Joan F. Flanagan

Authors
  1. Makoto Yono
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  2. Mehdi Pouresmail
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  3. Wataru Takahashi
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  4. Joan F. Flanagan
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  5. Robert M. Weiss
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  6. Jamshid Latifpour
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Correspondence to Jamshid Latifpour.

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Yono, M., Pouresmail, M., Takahashi, W. et al. Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes. Naunyn Schmied Arch Pharmacol 372, 251–255 (2005). https://doi.org/10.1007/s00210-005-0010-9

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  • DOI: https://doi.org/10.1007/s00210-005-0010-9

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