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Pregnancy- and lactation-associated vertebral compression fractures: MRI prevalence and characteristics

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Abstract

Summary

The frequency of pregnancy- and lactation-associated vertebral compression fractures (PLVCFs) is not known. This study showed that MRI prevalence of PLVCFs was approximately 0.5% in females ≥ 15 and < 40 years of age over a 48-month period. PLVCFs did not display MRI features distinguishing them from other vertebral insufficiency fractures.

Purpose

We aimed to investigate the MRI prevalence and characteristics of pregnancy- and lactation-associated vertebral compression fractures (PLVCFs).

Methods

This retrospective cross-sectional observational study included all thoracic, lumbar, or thoracolumbar MRI examinations performed in our hospital (or at outside centers and referred to us for consultation) of females ≥ 15 and < 40 years of age during a 48-month period. Two radiologists independently reviewed all images for vertebral compression fractures and their disagreement was resolved by a third blinded senior radiologist with 24 years of dedicated musculoskeletal radiology experience. MRI features of PLVCFs (early/late stage, height loss, endplate involvement, retropulsion) were noted.

Results

A total of 1484 MRI examinations—including 50 consultations from outside centers—of 1260 females (mean age, 27.7 years; range, 15–39) were included. Interobserver agreement of the two junior radiologists was substantial (κ = 0.607; 95% CI, 0.545–0.669). Vertebral compression fractures were identified in 177 of thoracic (n = 210), lumbar (n = 900), or thoracolumbar MRI (n = 374) examinations. Six women (7 MRI examinations; 4.0% of MRIs with vertebral fractures) had PLVCFs diagnosed on MRI (prevalence, 0.47%; mean age, 31 years; age range, 25–37). Number of fractured vertebrae in cases with PLVCF ranged between 1 and 11 (mean, 5.6). DEXA, available in all patients with PLVCFs, verified osteopenia/osteoporosis in four of six patients.

Conclusion

PLVCFs have an MRI prevalence of approximately 0.5% in the target population and do not display distinguishing features from other insufficiency type vertebral compression fractures.

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Data availability

Data can be made available upon request.

Abbreviations

CT:

Computed tomography

DEXA:

Dual energy X-ray absorptiometry

HIS:

Hospital information system

MRI:

Magnetic resonance imaging

PLO:

Pregnancy- and lactation-associated osteoporosis

PLVCF:

Pregnancy- and lactation-associated vertebral compression fracture

STIR:

Short tau inversion recovery

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Authors and Affiliations

  1. Department of Radiology, Hacettepe University School of Medicine, Sihhiye, 06100, Ankara, Turkey

    A. E. Yıldız, F. B. Ergen & Ü. Aydıngöz

  2. Department of Radiology, Ondokuz Mayıs University School of Medicine, Atakum, 55139, Samsun, Turkey

    A. B. Özbalcı

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  1. A. E. Yıldız
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  2. A. B. Özbalcı
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  3. F. B. Ergen
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  4. Ü. Aydıngöz
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Correspondence to A. E. Yıldız.

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Our institutional review board approved the study with a waiver of informed consent (protocol number: GO 19/568-16969557-1373).

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Yıldız, A.E., Özbalcı, A.B., Ergen, F.B. et al. Pregnancy- and lactation-associated vertebral compression fractures: MRI prevalence and characteristics. Osteoporos Int 32, 981–989 (2021). https://doi.org/10.1007/s00198-020-05754-w

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  • DOI: https://doi.org/10.1007/s00198-020-05754-w

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