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Aggravation of spinal cord compromise following new osteoporotic vertebral compression fracture prevented by teriparatide in patients with surgical contraindications

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Abstract

Summary

Patients with spinal cord deficits following new unstable osteoporotic compression fracture and surgical contraindications were considered to receive conservative treatment. Teriparatide was better than alendronate at improving bone mineral density and bone turnover parameters, as well as preventing aggravation of spinal cord compromise.

Introduction

This study compared the preventive effects of teriparatide and alendronate on aggravation of spinal cord compromise following new unstable osteoporotic vertebral compression fracture (OVCF) in patients with surgical contraindications.

Methods

This was a 12-month, randomized, open-label study of teriparatide versus alendronate in 49 patients with new unstable OVCF and surgical contraindications. Neurological function was evaluated using modified Japanese Orthopedic Association (mJOA) score (11-point scale, the maximum score of 11 implies normalcy). Visual analog scale (VAS) scores, kyphotic angles, anterior-border heights and diameters of the spinal canal of the fractured vertebrae, any incident of new OVCFs (onset of OVCF during follow-up), spine bone mineral density (BMD), and serum markers of bone resorption and bone formation were also examined at baseline and 1, 3, 6, and 12 months after initiation of the medication regimen.

Results

At 12 months, mean mJOA score had improved in the teriparatide group and decreased in the alendronate group. Mean concentrations of bone formation and bone resorption biomarkers, mean spine BMD, and mean anterior-border height and spinal canal diameter of the fractured vertebrae were significantly greater in the teriparatide group than in the alendronate group. Mean VAS score, mean kyphotic angle of the fractured vertebrae, and incidence of new OVCFs were significantly smaller in the teriparatide group than in the alendronate group.

Conclusions

In patients with neurological deficits following new unstable OVCF and with surgical contraindications, teriparatide was better than alendronate at improving the BMD and the bone turnover parameters, as well as preventing aggravation of spinal cord compromise.

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Acknowledgments

This work has been supported by the National Science Foundation of China 81471403 and 30973024. Ruoyan Xue contributed equally with the first author Ying Zhao in this study.

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Authors and Affiliations

  1. Department of Orthopaedics, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China

    Y. Zhao, Y. Xue, Y. Zong, W. Lin, B. Pei, C. Sun & R. Fan

  2. Department of Radiology, The Secondary Affiliated Hospital of Baotou Medical College, No. 22 Hudemulin Road, Qingshan District, Inner Mongolia, China

    Y. Zhao

  3. Department of Radiology and Tianjin Key Laboratory of Functional Imaging, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China

    R. Xue & Y. Jiang

  4. School of Medical Imaging, Tianjin Medical University, No. 1 Guandong Road, Hexi District, Tianjin, China

    R. Xue

  5. Department of Operative Surgery, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, China

    N. Shi

Authors
  1. Y. Zhao
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  2. R. Xue
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  3. N. Shi
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  4. Y. Xue
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  5. Y. Zong
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  7. B. Pei
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  8. C. Sun
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  9. R. Fan
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  10. Y. Jiang
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Corresponding author

Correspondence to Y. Xue.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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None.

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Zhao, Y., Xue, R., Shi, N. et al. Aggravation of spinal cord compromise following new osteoporotic vertebral compression fracture prevented by teriparatide in patients with surgical contraindications. Osteoporos Int 27, 3309–3317 (2016). https://doi.org/10.1007/s00198-016-3651-2

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  • DOI: https://doi.org/10.1007/s00198-016-3651-2

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