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Seasonal variation of serum α- and β-cryptoxanthin and 25-OH-vitamin D3 in women with osteoporosis

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Abstract

Summary

β-Cryptoxanthin displays a unique anabolic effect on bone calcification. In women with osteoporosis, serum β-cryptoxanthin and 25-OH-vitamin D3 showed a weak but significant correlation and exhibited a complementary seasonal distribution. The potential role of β-cryptoxanthin as a nutritional approach to improving bone health deserves further evaluation.

Introduction

Dietary intake and serum levels of β-cryptoxanthin have been inversely related to different bone and joint disorders and in vitro and animal studies have shown that β-cryptoxanthin displays a unique anabolic effect on bone calcification. Due to the emerging role of β-cryptoxanthin in bone biology, we aimed to assess the serum distribution and variability of β-cryptoxanthin and their potential relation to 25-OH-vitamin D3 in women with osteoporosis.

Methods

Serum concentrations of α- and β-cryptoxanthin and 25-OH- D3 in women with osteoporosis (N = 644) were analyzed using a quality-controlled high-performance liquid chromatography (HPLC) method.

Results

Overall, significant seasonal variations were found for the three analytes and inter-individual variation was also high (60–73%). β-cryptoxanthin and 25-OH-vitamin D3 exhibited a marked complementary seasonal distribution in serum, with vitamin D displaying the highest values in summer and β-cryptoxanthin in winter.

Conclusions

Given the anabolic effect of β-cryptoxanthin on bone calcification and its complementary seasonal distribution with respect to 25-OH-vitamin D3, the potential role of β-cryptoxanthin as a sustainable nutritional approach to improving bone health deserves to be further evaluated.

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Acknowledgements

The support of the Instituto de Salud Carlos III (Spain; PI 051610) is acknowledged. We are also indebted to Martha Messman for preparing the manuscript.

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Author notes

  1. B. Olmedilla-Alonso

    Present address: Departamento Metabolismo y Nutrición, Instituto del Frío-CSIC, c/ José Antonio Novais 10, 28040, Madrid, Spain

Authors and Affiliations

  1. Servicio de Bioquímica Clínica, Hospital Universitario Puerta de Hierro, Unidad de Vitaminas, 28035, Madrid, Spain

    F. Granado-Lorencio, B. Olmedilla-Alonso, C. Herrero-Barbudo, I. Blanco-Navarro & B. Pérez-Sacristán

Authors
  1. F. Granado-Lorencio
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  2. B. Olmedilla-Alonso
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  3. C. Herrero-Barbudo
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  4. I. Blanco-Navarro
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  5. B. Pérez-Sacristán
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Corresponding author

Correspondence to F. Granado-Lorencio.

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The authors declare that they have no conflicting financial interests.

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Granado-Lorencio, F., Olmedilla-Alonso, B., Herrero-Barbudo, C. et al. Seasonal variation of serum α- and β-cryptoxanthin and 25-OH-vitamin D3 in women with osteoporosis. Osteoporos Int 19, 717–720 (2008). https://doi.org/10.1007/s00198-007-0470-5

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  • DOI: https://doi.org/10.1007/s00198-007-0470-5

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