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The relationship between body composition and bone mineral content: threshold effects in a racially and ethnically diverse group of men

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Abstract

Summary

We examined BMC and body composition in 1,209 black, Hispanic, and white men. Weight, BMI, waist circumference, and fat mass were associated with BMC only up to certain thresholds, whereas lean mass exhibited more consistent associations. The protective influence of increased weight appears to be driven by lean mass.

Introduction

Reduced body size is associated with decreased bone mass and increased fracture risk, but associations in men and racially/ethnically diverse populations remain understudied. We examined bone mineral content (BMC) at the hip, spine, and forearm as a function of body weight, body mass index (BMI), waist circumference, fat mass (FM), and nonbone lean mass (LM).

Methods

The design was cross-sectional; 363 non-Hispanic black, 397 Hispanic, and 449 non-Hispanic white residents of greater Boston participated (N = 1,209, ages 30–79 y). BMC, LM, and FM were measured by DXA. Multiple linear regression was used to describe associations.

Results

Weight, BMI, waist circumference, and FM were associated with BMC only up to certain thresholds. LM, by contrast, displayed strong and consistent associations; in multivariate models, femoral neck BMC exhibited a 13% increase per 10 kg cross-sectional increase in LM. In models controlling for LM, positive associations between BMC and other body composition measures were eliminated. Results did not vary by race/ethnicity.

Conclusions

The protective effect of increased body size in maintaining bone mass is likely due to the influence of lean tissue. These results suggest that maintenance of lean mass is the most promising strategy in maintaining bone health with advancing age.

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Acknowledgements

The BACH/Bone study was supported by grant AG 20727 from the National Institute on Aging (NIA). The parent study (BACH) was supported by grant DK 56842 from the National Institute of Diabetes and Digestive and Kidney Diseases.

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Authors and Affiliations

  1. New England Research Institutes, Watertown, MA, 02472, USA

    T. G. Travison, A. B. Araujo, G. R. Esche & J. B. McKinlay

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  1. T. G. Travison
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  2. A. B. Araujo
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  3. G. R. Esche
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  4. J. B. McKinlay
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Correspondence to T. G. Travison.

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Travison, T.G., Araujo, A.B., Esche, G.R. et al. The relationship between body composition and bone mineral content: threshold effects in a racially and ethnically diverse group of men. Osteoporos Int 19, 29–38 (2008). https://doi.org/10.1007/s00198-007-0431-z

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  • DOI: https://doi.org/10.1007/s00198-007-0431-z

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