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Hormonal profiles and biochemical indices of bone turnover in Indian women

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Abstract

Summary

The study establishes Indian referent database for bone turnover markers. The levels of markers decreased across the four quartiles of BMD showing a negative correlation with BMD. The study depicts that levels of hormones and bone turnover makers can aid in identifying women at risk for osteoporosis.

Introduction

Biochemical markers of bone turnover reflect changes in bone metabolism earlier and aid in the management of osteoporosis. Since a referent database for Indian women is lacking, the study was initiated to establish the same and suggest that hormonal profiles and markers of bone turnover can aid in identifying women at risk for osteoporosis.

Methods

Osteocalcin (OC), bone specific alkaline phosphatase ((BSAP), C-terminal crosslinking telopeptide of type-I collagen (CTX-I), deoxypyridinoline (DPD), follicle-stimulating hormone (FSH) and estrone glucuronide (E1G) were measured in 365 Indian women (20–70 years) and correlated with BMD measurements by dual energy absorptiometry (DXA) using one way analysis of variance (ANOVA).

Results

The mean levels of bone resorption markers; CTX-I and DPD increased significantly across the age showing a negative correlation with BMD. The increase in levels of CTX-I and DPD was significantly higher (p < 0.0001) as compared to the femoral and spinal BMD, which dropped only 30–36%. The levels of bone turnover markers and FSH decreased across the four quartiles of spinal and femoral BMD showing a negative correlation whereas E1G levels increased across the four quartiles.

Conclusion

The bone turnover markers were comparatively low in cohort of Indian women studied.

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Acknowledgement

The authors are also grateful to Dr. C.P. Puri, Director of the Institute for his support and encouragement. We are grateful to the social worker Mrs. Mohini Baji from the clinic for her valuable assistance during the recruitment of subjects. Our special thanks goes to Mr. Hemant Karekar for graphical presentation of data. The financial support from the Dept. of Science and Technology is highly acknowledged.

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Authors and Affiliations

  1. Department of Molecular Immunodiagnostics, National Institute for Research in Reproductive Health (ICMR), J.M. Street, Parel, Mumbai, India

    P. Desai Meena, M. I. Khatkhatay, K. V. Bhanu Prakash & Z. Ansari

  2. Department of Clinical Research, National Institute for Research in Reproductive Health (ICMR), J.M. Street, Parel, Mumbai, India

    L. S. Savardekar & R. S. Shah

Authors
  1. P. Desai Meena
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  2. M. I. Khatkhatay
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  3. K. V. Bhanu Prakash
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  4. L. S. Savardekar
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  5. R. S. Shah
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  6. Z. Ansari
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Corresponding author

Correspondence to P. Desai Meena.

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Desai Meena, P., Khatkhatay, M.I., Bhanu Prakash, K.V. et al. Hormonal profiles and biochemical indices of bone turnover in Indian women. Osteoporos Int 18, 923–929 (2007). https://doi.org/10.1007/s00198-006-0318-4

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  • DOI: https://doi.org/10.1007/s00198-006-0318-4

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