Skip to main content
Log in

Role of collagen and other organics in the mechanical properties of bone

  • Original Article
  • Published:
Osteoporosis International Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1.
Fig. 2.
Fig. 3. A–D.
Fig. 4.

References

  1. Benezra-Rosen V, Hobbs L, Spector M (2002) The ultrastructure of anorganic bovine bone and selected synthetic hyroxyapatites used as bone graft substitute materials. Biomaterials 23:921–928

    Article  CAS  PubMed  Google Scholar 

  2. Hellmich C, Ulm FJ (2002) Are mineralized tissues open crystal foams reinforced by crosslinked collagen? Some energy arguments. J Biomech 35:1199–1212

    Article  PubMed  Google Scholar 

  3. Carter D, Scully A, Heaton D, Young M, Aaron J (2002) Effect of deproteination on bone mineral morphology: implications for biomaterials and aging. Bone 31:389–395

    Article  CAS  PubMed  Google Scholar 

  4. Currey JD (2002) Bones: structure and mechanics. Princeton University Press, Princeton

  5. Papdimitrious H, Swartz S, Kunz T (1996) Ontogenetic and anatomic variation in mineralization of the wing skeleton of the mexican free-tailed bat, Tadara brasiliensis. J Zool (Lond) 240:411–426

    Google Scholar 

  6. Currey JD, Foreman J, Laketić I, et al (1997) Effects of ionizing radiation on the mechanical properties of human bone. J Orthop Res 15:111–117

    CAS  PubMed  Google Scholar 

  7. Hamer AJ, Stockley I, Elson RA (1999) Changes in allograft bone irradiated at different temperatures. J Bone Joint Surg Br 81:342–344

    Article  CAS  PubMed  Google Scholar 

  8. Bailey AJ, Knott L (2002) The role of collagen in the aging of bone. Morphological, biochemical, molecular and social aspects. In: Meissner C (ed) Research in legal medicine. Schmidt-Römhild, Lübeck, pp 217–232

  9. Knott L, Bailey AJ (1998) Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance. Bone 22:181–187

    Article  CAS  PubMed  Google Scholar 

  10. Paul RG, Bailey AJ (1996) Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes. Int J Biochem Cell Biol 28:1297–1310

    Article  CAS  PubMed  Google Scholar 

  11. Bailey AJ, Sims TJ, Ebbesen EN, et al (1999) Age-related changes in the biochemical properties of human cancellous bone collagen: relationship to bone strength. Calcif Tissue Int 65:203–210

    Article  CAS  PubMed  Google Scholar 

  12. Hou O, Paschalis E, Boskey AL, Mendelsohn R (2002) Chemical structure-based three-dimensional reconstruction of human cortical bone from two-dimensional infrared images. Appl Spectrosc 56:419–422

    Google Scholar 

  13. Wang X, Shen X, Li X, Mauli Agrawal C (2002) Age-related changes in the collagen network and toughness of bone. Bone 31:1–7

    Article  PubMed  Google Scholar 

  14. Vashishth D, Gibson GJ, Khoury JI, et al (2001) Influence of nonenzymatic glycation on biomechanical properties of cortical bone. Bone 28:195–201

    Article  CAS  PubMed  Google Scholar 

  15. Odetti P, Aragno I, Rolandi R, et al (2000) Scanning force microscopy reveals structural alterations in diabetic rat collagen fibrils: role of protein glycation. Diabetes Metab Res Rev 16:74–81

    Article  CAS  PubMed  Google Scholar 

  16. Zioupos P, Currey JD, Hamer AJ (1999) The role of collagen in the declining mechanical properties of aging human cortical bone. J Biomed Mater Res 45:108–116

    Article  CAS  PubMed  Google Scholar 

  17. Bailey AJ, Sims TJ, Knott L (2002) Phenotypic expression of osteoblast collagen in osteoarthritic bone: production of type I homotrimer. Int J Biochem Cell Biol 34:176–182

    Article  CAS  PubMed  Google Scholar 

  18. Jepsen KJ, Goldstein SA, Kuhn JL, Schaffler MB, Bonadio J (1996) Type-I collagen mutation compromises the post-yield behavior of Mov13 long bone. J Orthop Res 14:493–499

    CAS  PubMed  Google Scholar 

  19. Grabner B, Landis WJ, Roschger P, et al (2001) Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim). Bone 29:453–457

    Article  CAS  PubMed  Google Scholar 

  20. Luchinetti E (2001) Composite models of bone properties. In: Cowin S (ed) Bone mechanics handbook. CRC Press, Boca Raton, pp 12–19

  21. Misof K, Landis WJ, Klaushofer K, Fratzl P (1997) Collagen from the osteogenesis imperfecta mouse model (oim) shows reduced resistance against tensile stress. J Clin Invest 100:40–45

    CAS  PubMed  Google Scholar 

  22. Corsi A, Xu T, Chen XD, et al (2002) Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues.PG. J Bone Miner Res 17:1180–1189

    CAS  PubMed  Google Scholar 

  23. McKee MD, Nanci A (1996) Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair. Microsc Res Tech 33:141–164

    Article  CAS  PubMed  Google Scholar 

  24. Jepsen KJ, Davy DT, Krzypow DJ (1999) The role of the lamellar interface during torsional yielding of human cortical bone. J Biomech 32:303–310

    Article  CAS  PubMed  Google Scholar 

  25. Efstathiadou Z, Tsatsoulis A, Ioannidis JP (2001) Association of collagen Ialpha 1 Sp1 polymorphism with the risk of prevalent fractures: a meta-analysis. J Bone Miner Res 16:1586–1592

    CAS  PubMed  Google Scholar 

  26. McGuigan FE, Armbrecht G, Smith R, et al (2001) Prediction of osteoporotic fractures by bone densitometry and COLIA1 genotyping: a prospective, population-based study in men and women. Osteoporos Int 12:91–96

    Article  CAS  PubMed  Google Scholar 

  27. Rice JC, Cowin SC, Bowman JA (1988) On the dependence of the elasticity and strength of cancellous bone on apparent density. J Biomech 21:155–168

    CAS  PubMed  Google Scholar 

  28. Homminga J, McCreadie BR, Ciarelli TE, et al (2002) Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level. Bone 30:759–764

    Article  CAS  PubMed  Google Scholar 

  29. Rodan GA (2002) Bisphosphonates and primary hyperparathyroidism. J Bone Miner Res 17 [Suppl 2]:N150–N153

    Google Scholar 

  30. Mashiba T, Turner CH, Hirano T, et al (2001) Effects of high-dose etidronate treatment on microdamage accumulation and biomechanical properties in beagle bone before occurrence of spontaneous fractures. Bone 29:271–278

    Article  CAS  PubMed  Google Scholar 

  31. Sarkar S, Mitlak BH, Wong M, et al (2002) Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res 17:1–10

    CAS  PubMed  Google Scholar 

  32. Mashiba T, Mori S, Li J, et al (2002) Increased degree of mineralization by bisphosphonate does not increase intrinsic mechanical properties of bone due to microdamage accumulation. J Bone Min Res 17:OC13

    Google Scholar 

  33. Liu D, Wagner H, Weiner S (2000) Bending and fracture of compact circumferential and osteonal lamellar bone of the baboon tibia. J Mat Sci: Mat Med 11:49–60

    Google Scholar 

  34. Burr D (2002) The contribution of the organic matrix to the bone's material properties. Bone 31:8–11

    Article  CAS  PubMed  Google Scholar 

  35. Fisher L (2002) How to dunk a doughnut: The science of everyday life. Weidenfeld and Nicholson, London

    Google Scholar 

  36. Currey JD (1999) What determines the bending strength of compact bone? J Exp Biol 202:2495–2503

    PubMed  Google Scholar 

Download references

Author information

Consortia

Rights and permissions

Reprints and permissions

About this article

Cite this article

John D. Currey. Role of collagen and other organics in the mechanical properties of bone. Osteoporos Int 14 (Suppl 5), 29–36 (2003). https://doi.org/10.1007/s00198-003-1470-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00198-003-1470-8

Keywords

Navigation