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Searching for osteoporosis genes in the post-genome era: progress and challenges

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Abstract

Osteoporosis is a common skeletal disease characterized by low bone mineral density (BMD), deterioration of bone microarchitecture and increased fracture risk. It is a complex disease that has high social and economic costs. Osteoporosis and its associated phenotypes are under the strong genetic control. Identification and characterization of specific loci or genes involved in determining osteoporosis and its associated phenotypes will contribute to a greater understanding of the pathogenesis of osteoporosis, and ultimately might lead to the development of better diagnosis, prevention and treatment strategies. Efforts to identify osteoporosis genes have focused on three approaches: animal models, candidate gene approach, and genome-wide scans. In this article, we review the current status for mapping and identification of genes for osteoporosis, with a focus on some promising regions and future prospects.

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Acknowledgements

Investigators of this work are partially supported by grants from Health Future Foundation, NIH grants (K01 AR02170-01, R01 AR45349-01, R01 GM60402-01A1, P01 DC01813-07), grants from State of Nebraska Cancer and Smoking Related Disease Research Program (LB595) and the Nebraska Tobacco Settlement Fund (LB692), US Department of Energy grant DE-FG03–00ER63000/A00, Creighton University, grants (30025025, 30170504, 30230210) from National Science Foundation of China, a Seed Fund (25000106) and a key grant from the Ministry of Education of People's Republic of China, a grant (25000612) from HuNan Normal University, a grant (81017) from Huo Ying Dong Foundation.

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  1. Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081, ChangSha, Hunan, People's Republic of China

    Qing-Yang Huang & Hong-Wen Deng

  2. Osteoporosis Research Center, Creighton University, 601 N. 30th Street, Suite 6787, Omaha, NE, 68131, USA

    Qing-Yang Huang, Robert R. Recker & Hong-Wen Deng

  3. Department of Biomedical Sciences, Creighton University, 601 N. 30th Street, Suite 6787, Omaha, NE, 68131, USA

    Qing-Yang Huang & Hong-Wen Deng

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  1. Qing-Yang Huang
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Correspondence to Hong-Wen Deng.

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Huang, QY., Recker, R.R. & Deng, HW. Searching for osteoporosis genes in the post-genome era: progress and challenges. Osteoporos Int 14, 701–715 (2003). https://doi.org/10.1007/s00198-003-1445-9

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