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Zentrale pontine Myelinolyse

Central pontine myelinolysis

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Zusammenfassung

Die zentrale pontine Myelinolyse (CPM) ist durch eine symmetrische, primär nichtentzündliche Demyelinisierung des Hirnstamms charakterisiert. Nach neuerer Auffassung können diesem Krankheitsbild mehrere Ursachen zugrunde liegen. Ein lange bekannter Auslöser ist der chronische Alkoholabusus. Am Beispiel eines 37 Jahre alt gewordenen Mannes mit anamnestisch bekanntem jahrelangen schweren Alkoholabusus werden typische histologische Zeichen und Befunde einer tödlich ausgegangen CPM dargestellt.

Abstract

Central pontine myelinolysis (CPM) is characterized by a symmetrical, primarily non-inflammatory demyelinization of the brainstem. According to the latest concepts this disease could have a variety of causes. One well known trigger is alcohol abuse. Typical histological signs and findings of a fatal CPM are demonstrated using the example of a deceased 37-year-old male with a long history of severe alcohol abuse.

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Authors and Affiliations

  1. Institut für Rechtsmedizin, Charité – Universitätsmedizin Berlin, Turmstr. 21 (Haus L), 10559, Berlin, Deutschland

    S. Schalinski, S. Schmid &  M. Tsokos

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  1. S. Schalinski
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  2. S. Schmid
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  3. M. Tsokos
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Correspondence to M. Tsokos.

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Schalinski, S., Schmid, S. & Tsokos, M. Zentrale pontine Myelinolyse. Rechtsmedizin 18, 454–456 (2008). https://doi.org/10.1007/s00194-008-0567-y

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  • DOI: https://doi.org/10.1007/s00194-008-0567-y

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