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Prevalence of metabolic syndrome and its components in women with and without pelvic organ prolapse and its association with prolapse severity according to the Pelvic Organ Prolapse Quantification system

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Abstract

Introduction and hypothesis

Data regarding possible associations between metabolic syndrome (MS) and pelvic organ prolapse (POP) are scarce. The primary hypothesis was that the prevalence of MS and its components was higher in postmenopausal women with POP than in age-matched women without POP staged with the Pelvic Organ Prolapse Quantification system (POP-Q). The secondary aim of the study was to analyze the association between MS and its components with POP severity.

Methods

Presence of MS and its components [elevated triglycerides (TG), waist circumference, blood pressure, and fasting glucose (FG) and decreased high-density lipoprotein cholesterol (HDL-C)] were assessed in 122 women with POP (POP-Q stage I–IV) and 77 without (POP-Q 0). Fasting insulin resistance [homeostasis model assessment for fasting insulin resistance (HOMA-IR)] was also assessed.

Results

TG levels, FG, and HOMA index were significantly higher in POP-Q stage I–IV compared with POP-Q 0 (p = 0.04, p = 0.0005 and p = 0.04); HDL-C was significantly reduced in POP-Q stage I-IV compared with POP-Q 0 (p = 0.0003). TG levels (p = 0.0315) were significantly higher in POP-Q stage III and IV vs. POP-Q 0; FG and HOMA-IR (p = 0.0015 and p = 0.0204) were significantly higher in POP-Q stage IV vs. POP-Q 0; HDL-C (p = 0.0047) was significantly lower in all stages vs. POP-Q 0. The prevalence of MS was different between groups (p = 0.04) and higher in POP-Q IV. Elevated TG [odds ratio (OR) 4.6, 95% confidence interval (CI) 1.5–9.3, p = 0.004] and reduced HDL-C (OR 2.0, 95% CI 1.1–3.7, p = 0.0241) significantly increased the risk of POP-Q stage ≥III.

Conclusions

MS and its components may be associated with POP. Elevated TG and reduced HDL-C are associated with POP severity.

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Acknowledgements

The authors thank Julie Norbury for English copy editing.

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Authors and Affiliations

  1. Gynecology and Physiopathology of Human Reproduction, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy

    Giulia Gava, Stefania Alvisi, Ilaria Mancini, Renato Seracchioli & Maria Cristina Meriggiola

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  1. Giulia Gava
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  2. Stefania Alvisi
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Correspondence to Giulia Gava.

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Summary

Metabolic syndrome and its components may be associated with pelvic organ prolapse and increasing pelvic organ prolapse severity.

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Gava, G., Alvisi, S., Mancini, I. et al. Prevalence of metabolic syndrome and its components in women with and without pelvic organ prolapse and its association with prolapse severity according to the Pelvic Organ Prolapse Quantification system. Int Urogynecol J 30, 1911–1917 (2019). https://doi.org/10.1007/s00192-018-3840-y

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  • DOI: https://doi.org/10.1007/s00192-018-3840-y

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