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Double-blinded randomized trial of preoperative antibiotics in midurethral sling procedures and review of the literature

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Abstract

Introduction and hypothesis

The objective of this study was to determine if prophylactic antibiotic use before midurethral sling procedures reduces infectious complications.

Methods

In this double-blinded randomized trial, we compared infectious complications between women who received cefazolin and placebo before midurethral sling procedures.

Results

The study was halted due to low rate of infectious outcomes seen at the first scheduled interim analysis. We enrolled 29 women in the cefazolin group and 30 in the placebo group. Total follow-up was 6 months (3–24 months). The groups were similar at the baseline. There was no statistically significant difference between the cefazolin and placebo groups, respectively, with respect to wound infections [1 (3.3%) and 0 (0%)], mesh exposure [0 (0%) and 1 (3.5%)], and bacteriuria [3 (10%) and 1 (3.5%)].

Conclusion

Because infection rates are low in both cefazolin and placebo groups, omitting preoperative antibiotics for midurethral slings may be justified.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Tufts University School of Medicine, Baystate Medical Center, 759 Chestnut Street, S-1681, Springfield, MA, 01199, USA

    Oz Harmanli, Rebecca L. Boyer, Stephen Metz, Elena Tunitsky & Keisha A. Jones

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  1. Oz Harmanli
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  2. Rebecca L. Boyer
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  3. Stephen Metz
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  4. Elena Tunitsky
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  5. Keisha A. Jones
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Correspondence to Oz Harmanli.

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Harmanli, O., Boyer, R.L., Metz, S. et al. Double-blinded randomized trial of preoperative antibiotics in midurethral sling procedures and review of the literature. Int Urogynecol J 22, 1249–1253 (2011). https://doi.org/10.1007/s00192-011-1500-6

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  • DOI: https://doi.org/10.1007/s00192-011-1500-6

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