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Validity and reliability of patient selected goals as an outcome measure in overactive bladder

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Abstract

Introduction and hypothesis

The purpose of this study is to assess the validity of patient goal achievement in overactive bladder (OAB).

Methods

Data were taken from a placebo-controlled randomised trial of transdermal oxybutynin and open label extension study. Face validity was assessed using qualitative analysis. Convergent validity was assessed by comparison with objective symptom improvement. Responsiveness was assessed at 4 s, using the standardised effect size. Reliability was assessed between 4 and 12 weeks of treatment.

Results

Ninety-six women were randomised. There were moderate correlations (0.50–0.51) between goal achievement and symptom improvement for urinary urgency and urge incontinence. Mean goal achievement demonstrated good reliability (intraclass correlation = 0.82) but low responsiveness (r = 0.14) between transdermal oxybutynin and placebo-treated groups.

Conclusions

Although patient goals have good face validity and can be reliably measured, they have limited convergence with conventional measures of OAB severity and improvement and low responsiveness.

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Conflicts of interest

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Authors and Affiliations

  1. Department of Urogynaecology, King’s College Hospital, Denmark Hill, London, SE5 9RS, UK

    Rufus Cartwright, Sushma Srikrishna, Linda Cardozo & Dudley Robinson

Authors
  1. Rufus Cartwright
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  2. Sushma Srikrishna
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  3. Linda Cardozo
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  4. Dudley Robinson
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Corresponding author

Correspondence to Rufus Cartwright.

Additional information

Trial registration

EUDRACT 2005-005009-41 http://eudract.emea.europa.eu ISRCTN 87161129 http://www.isrctn.org

Funding

Unrestricted educational grant from UCB Pharma, without involvement in data analysis or preparation of the manuscript

Ethics

Study approved by King’s College Hospital Research Ethics Committee

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Cartwright, R., Srikrishna, S., Cardozo, L. et al. Validity and reliability of patient selected goals as an outcome measure in overactive bladder. Int Urogynecol J 22, 841–847 (2011). https://doi.org/10.1007/s00192-011-1360-0

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  • DOI: https://doi.org/10.1007/s00192-011-1360-0

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