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Long-term results of intravesical hyaluronan therapy in bladder pain syndrome/interstitial cystitis

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Abstract

Introduction and hypothesis

While the short-term efficacy of intravesical hyaluronan for bladder pain syndrome/interstitial cystitis (BPS/IC) has been demonstrated, no data exist on the long-term outcome of this therapy.

Methods

Seventy BPS/IC patients treated with intravesical hyaluronan therapy from 2001 to 2003 were asked to rate their present status of bladder symptoms on a visual analog scale.

Results

Forty-eight of 70 patients responded after a mean follow-up of 4.9 years. The average initial VAS score of 8.15 had been reduced to 2.71 after therapy and further to 2.14 5 years later. Fifty percent of patients (24/48) reported complete bladder symptom remission at 5 years follow-up without any additional therapy; 41.7% (20/48) with symptom recurrence was improved with hyaluronan maintenance therapy. No improvement was reported by four patients.

Conclusions

Besides a high rate of acute symptom remission, intravesical hyaluronan also shows long-term efficacy in a considerable number of BPS/IC patients.

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Conflicts of interest

Claus R. Riedl is the principal investigator for controlled study on Hyaluronan in BPS/IC (CISTIC).

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Authors and Affiliations

  1. Department of Urology, Landesklinikum Thermenregion Baden, Wimmergasse 19, 2500, Baden, Austria

    Paul F. Engelhardt, Nike Morakis & Claus R. Riedl

  2. Department of Urology, Krankenhaus Hietzing, Vienna, Austria

    Lukas K. Daha

  3. Urologic Clinic, Paracelsus University of Medicine, Salzburg, Austria

    Britta Esterbauer

Authors
  1. Paul F. Engelhardt
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  2. Nike Morakis
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  3. Lukas K. Daha
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  4. Britta Esterbauer
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  5. Claus R. Riedl
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Corresponding author

Correspondence to Paul F. Engelhardt.

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Engelhardt, P.F., Morakis, N., Daha, L.K. et al. Long-term results of intravesical hyaluronan therapy in bladder pain syndrome/interstitial cystitis. Int Urogynecol J 22, 401–405 (2011). https://doi.org/10.1007/s00192-010-1294-y

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  • DOI: https://doi.org/10.1007/s00192-010-1294-y

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