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Foreign body reaction in vaginally eroded and noneroded polypropylene suburethral slings in the female: a case series

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Abstract

Introduction and hypothesis

Aim of this study was to investigate the pattern of the foreign body reaction of macroporous polypropylene mesh (MPPM) used in females for the treatment of stress urinary incontinence and to compare this pattern between eroded and noneroded tapes.

Methods

Ten explanted suburethral slings, five eroded and five noneroded, were examined immunohistochemically under light microscopy; the tissue reaction was compared between eroded and noneroded materials.

Results

Eroded material showed a significantly higher accumulation of macrophages around the filaments of the mesh.

Conclusions

This is the first study comparing reaction around eroded and noneroded MPPMs and indicates a more intense tissue reaction around eroded mesh, when compared to noneroded material. More studies are needed to prove whether the detected foreign body reaction was the actual trigger for the erosion.

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Abbreviations

SUI:

stress urinary incontinence

MPPM:

macroporous polypropylene mesh

MMP:

matrix metalloproteinase

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Cantonal Hospital Lucerne, St. Karliquai 9, 6004, Lucerne, Switzerland

    Tilemachos Kavvadias, Stefanie Kuschel & Bernhard Schuessler

  2. Department of Surgery, University Hospital Aachen, Aachen, Germany

    Daniel Kaemmer & Uwe Klinge

Authors
  1. Tilemachos Kavvadias
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  2. Daniel Kaemmer
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  3. Uwe Klinge
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  4. Stefanie Kuschel
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  5. Bernhard Schuessler
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Correspondence to Tilemachos Kavvadias.

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Kavvadias, T., Kaemmer, D., Klinge, U. et al. Foreign body reaction in vaginally eroded and noneroded polypropylene suburethral slings in the female: a case series. Int Urogynecol J 20, 1473–1476 (2009). https://doi.org/10.1007/s00192-009-0974-y

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  • DOI: https://doi.org/10.1007/s00192-009-0974-y

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