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Fibulin-5 expression is decreased in women with anterior vaginal wall prolapse

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Abstract

The aim of this study was to compare fibulin-5 expression in women with and without anterior vaginal wall prolapse. Vaginal tissues were sampled in a standardized fashion from women with (n = 12) or without (n = 10) anterior vaginal wall prolapse. Quantitative real-time polymerase chain reaction was performed to measure mRNA levels of fibulin-5 (FIB-5). FIB-5 protein expression was assessed by immunohistochemistry. There were no significant differences in demographic data between the two groups. FIB-5 mRNA expression was significantly decreased in women with anterior vaginal wall prolapse compared to women without prolapse [(FIB-5 mean ± SD mRNA expression in relative units) 0.01 ± 0.01 vs. 0.09 ± 0.14, P = 0.04]. Fibulin-5 staining intensity was diminished in women with prolapse compared to women without prolapse [intensity score, median (range), 1 (1–2) vs. 3 (2–3), P = 0.04]. Fibulin-5 expression is decreased in vaginal biopsies from women with prolapse. Changes in fibulin expression may play a role in the development of pelvic organ prolapse.

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Authors and Affiliations

  1. Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology (D-50), Miller School of Medicine, University of Miami-Jackson Memorial Hospital, P.O. Box 016960, Miami, FL, 33010, USA

    Peter Takacs & Carlos A. Medina

  2. Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL, 33010, USA

    Mehdi Nassiri & Anita Viciana

  3. Department of Anesthesiology, Miller School of Medicine, University of Miami, Miami, FL, 33010, USA

    Keith Candiotti

  4. Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, 33010, USA

    Alessia Fornoni

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  1. Peter Takacs
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  2. Mehdi Nassiri
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  3. Anita Viciana
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  4. Keith Candiotti
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  5. Alessia Fornoni
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  6. Carlos A. Medina
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Correspondence to Peter Takacs.

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Takacs, P., Nassiri, M., Viciana, A. et al. Fibulin-5 expression is decreased in women with anterior vaginal wall prolapse. Int Urogynecol J 20, 207–211 (2009). https://doi.org/10.1007/s00192-008-0757-x

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  • DOI: https://doi.org/10.1007/s00192-008-0757-x

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