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Is single-dose fosfomycin trometamol a good alternative for asymptomatic bacteriuria in the second trimesterof pregnancy?

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Abstract

Untreated asymptomatic bacteriuria has been associated with acute pyelonephritis, which may have a role in many maternal and fetal complications. Acute pyelonephritis in pregnancy is related to anemia, septicemia, transient renal dysfunction, and pulmonary insufficiency. A randomized study was conducted to assess the clinical and microbiological efficacy of a single dose of fosfomycin trometamol for the treatment of asymptomatic bacteriuria in the second trimester of pregnancy compared with a 5-day regimen of cefuroxime axetyl. Forty-four women received fosfomycin trometamol and 40 women received cefuroxime axetyl. There were no statistically significant differences between both groups regarding the mean age and mean duration of pregnancy. Therapeutic success was achieved in 93.2% of the patients treated with fosfomycin trometamol vs 95% of those treated with cefuroxime axetyl. A single dose of fosfomycin trometamol is a safe and effective alternative in the treatment of asymptomatic urinary tract infections in the second trimester of pregnancy.

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Authors and Affiliations

  1. Department of Urology, Fatih University School of Medicine, Alpaslan Türkeş cad., 06510 Emek, Ankara, Turkey

    Ömer Bayrak, Ersin Çimentepe & Akif Koç

  2. Department of Obstetric and Gynecology, Fatih University School of Medicine, Ankara, Turkey

    İlknur İnegöl, Candan İltemir Duvan & Nilgün Öztürk Turhan

  3. 1st Urology Clinic, Atatürk Education and Training Hospital, Ankara, Turkey

    Ali Fuat Atmaca

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  1. Ömer Bayrak
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  2. Ersin Çimentepe
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  3. İlknur İnegöl
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  4. Ali Fuat Atmaca
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  5. Candan İltemir Duvan
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  6. Akif Koç
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  7. Nilgün Öztürk Turhan
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Correspondence to Ömer Bayrak.

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Bayrak, Ö., Çimentepe, E., İnegöl, İ. et al. Is single-dose fosfomycin trometamol a good alternative for asymptomatic bacteriuria in the second trimesterof pregnancy?. Int Urogynecol J 18, 525–529 (2007). https://doi.org/10.1007/s00192-006-0190-y

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  • DOI: https://doi.org/10.1007/s00192-006-0190-y

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