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Massive prolapse of the urethral mucosa following periurethral injection of calcium hydroxylapatite for stress urinary incontinence

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Abstract

The injection of bulking agents into the urethral submucosa is designed to create artificial urethral cushions that can improve urethral coaptation and hence restore continence. Ideally, a urethral bulking agent should be non-immunogenic and biocompatible, leading to minimal inflammatory and fibrotic response. The authors present a case report of a granulomatous reaction leading to urethral prolapse, 3 months after the transurethral injection of calcium hydroxylapatite. To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.

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References

  1. Dmochowski R, Appell R, Klimberg I, Mayer R (2002) Initial clinical results from coaptite injection for stress urinary incontinence comparative clinical study (Abstract). In: Proceedings of the International Continence Society (ICS), 32nd Annual Meeting, Heidelberg, Germany 28-30 Aug. 2002, pp184–185

  2. Pickard R, Reaper J, Wyness L, Cody DJ, McClinton S, N’Dow J (2005) Periurethral injection therapy for urinary incontinence in women (Cochrane Review). In: The Cochrane Library, Issue 1, Update Software, Oxford

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Authors and Affiliations

  1. Division of Urology, Campinas State University-UNICAMP, São Paulo, Brazil

    Paulo C. R. Palma, Cássio L. Z. Riccetto, Mario Henrique T. Martins, Rogerio de Fraga & Nelson Rodrigues Netto Jr.

  2. Division of Gynecology, Campinas State University-UNICAMP, São Paulo, Brazil

    Viviane Herrmann

  3. Division of Pathology, Campinas State University-UNICAMP, São Paulo, Brazil

    Athanase Billis

Authors
  1. Paulo C. R. Palma
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  2. Cássio L. Z. Riccetto
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  3. Mario Henrique T. Martins
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  4. Viviane Herrmann
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  5. Rogerio de Fraga
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  6. Athanase Billis
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  7. Nelson Rodrigues Netto Jr.
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Corresponding author

Correspondence to Mario Henrique T. Martins.

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Palma, P.C.R., Riccetto, C.L.Z., Martins, M.H.T. et al. Massive prolapse of the urethral mucosa following periurethral injection of calcium hydroxylapatite for stress urinary incontinence. Int Urogynecol J 17, 670–671 (2006). https://doi.org/10.1007/s00192-005-0038-x

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  • DOI: https://doi.org/10.1007/s00192-005-0038-x

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