Abstract
A multi-step dip-spin coating procedure by which synthetic vessels of virtually the entire cardiovascular system can be constructed from medical imaging data was developed to consistently and accurately fabricate silicone membranes with prescribed compliance for in vitro hemodynamic experimentation and medical device development. Experimental results showed that the three factors tested (silicone mixture viscosity, mold diameter, and number of dips in solution) each had a statistically significant effect on the resulting wall thickness of the fabricated silicone membranes. A setup was designed and constructed to test the compliance of the silicone membranes, and a prediction model showed that the most important factors for compliance were the mean pressure used to pressurize the membranes, the membrane wall thickness, and the difference in membrane diameter between the two test pressures. The manufacturing process was repeatable with a process standard deviation of 0.002753 cm for an average wall thickness of 0.063576 cm (4.33%).
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Acknowledgements
The research presented here was performed at UTEP in the W.M. Keck Border Biomedical Manufacturing and Engineering Laboratory (W.M. Keck BBMEL) using equipment purchased through Grant #11804 from the W.M. Keck Foundation. Support for UTEP was also provided through a research contract (#28643) from Sandia National Laboratories (SNL) in the Laboratory Directed Research and Development (LDRD) program, and the technical guidance of Alan Parker, Manager of Mechanical Engineering at SNL, is appreciated. Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy’s National Nuclear Security Administration under contract DE-AC04-94AL85000. The financial support and guidance of Edward Egbert, M.D., on this project was invaluable. The authors are grateful to Dr. Charles Taylor at Stanford University for providing the geometric computer model of the stenosed pig aorta used to demonstrate the compliant vessel manufacturing process. The opinions expressed in this paper are those of the authors and do not necessarily reflect those of any other individuals or sponsors of the W.M. Keck BBMEL or its research.
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Cortez, M.A., Quintana, R. & Wicker, R.B. Multi-step dip-spin coating manufacturing system for silicone cardiovascular membrane fabrication with prescribed compliance. Int J Adv Manuf Technol 34, 667–679 (2007). https://doi.org/10.1007/s00170-006-0649-5
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DOI: https://doi.org/10.1007/s00170-006-0649-5