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Preexisting and treated concomitant ankle instability does not compromise patient-reported outcomes of solitary osteochondral lesions of the talus treated with matrix-induced bone marrow stimulation in the first postoperative year: data from the German Cartilage Registry (KnorpelRegister DGOU)

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Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

Purpose

The purpose of this study was to compare the subjective ankle function within the first year following matrix-induced bone marrow stimulation (M-BMS) of patients with a solitary osteochondral lesion of the talus (OCLT) with and without concomitant chronic ankle instability (CAI).

Methods

Data from the German Cartilage Registry (KnorpelRegister DGOU) for 78 patients with a solitary OCLT and a follow-up of at least 6 months were included. All patients received M-BMS for OCLT treatment. The cohort was subdivided into patients with OCLT without CAI treated with M-BMS alone (n = 40) and patients with OCLT and CAI treated with M-BMS and additional ankle stabilisation (n = 38). The Foot and Ankle Ability Measure (FAAM), the Foot and Ankle Outcome Score (FAOS), and the Numeric Rating Scale for Pain (NRS) were used to assess patient-reported outcomes (median (minimum–maximum)).

Results

From preoperatively to 12 months postoperatively, patients with OCLT without CAI treated with M-BMS alone had a significant improvement of all subscales in the FAAM [activity of daily living 64.3 (10–100) to 88.1 (39–100); sports 34.4 (0–100) to 65.6 (13–94), functional activities of daily life 50 (0–90) to 80 (30–100), functional sports 30 (0–100) to 70 (5–100)] and FAOS [pain 61.1 (8–94) to 86.1 (50–100), symptoms 60.7 (18–96) to 76.8 (29–100), activities of daily living 72.1 (24–100) to 91.9 (68–100), sport/recreational activities 30.0 (0–70) to 62.5 (0–95), quality of life 31.3 (6–50) to 46.9 (19–100)]. Within the first year, patients with OCLT and CAI treated with M-BMS and ankle stabilisation also showed significant improvement in the FAAM [activity of daily living 68.8 (5–99) to 90.5 (45–100); sports 32.8 (0–87.5) to 64.1 (0–94), functional activities of daily life 62.5 (25–100) to 80 (60–90), functional sports 30 (0–100) to 67.5 (0.95)] and the FAOS [pain 66.7 (28–92) to 87.5 (47–100), symptoms 57.1 (29–96) to 78.6 (50–100), activities of daily living 80.1 (25–100) to 98.5 (59–100), sport/recreational activities 35.0 (0–100) to 70.0 (0–100), quality of life 25.0 (0–75) to 50.0 (19–94)]. The pain level decreased significantly in both groups. No significant difference was found between both groups regarding the subscales of FAAM, FAOS and the NRS 1 year postoperatively.

Conclusion

Improvements in subjective ankle function, daily life activities and sports activities were observed within the first year following M-BMS. Our results suggest that preexisting and treated ankle instability did not compromise subjective outcome in patients treated with M-BMS in the first postoperative year.

Level of evidence

Level IV.

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Abbreviations

AS:

Ankle stabilisation

M-BMS:

Matrix-induced bone marrow stimulation

AOFAS:

American Orthopedic Foot and Ankle Society

BHL:

Berndt–Harty–Loomer

CAI:

Chronic ankle instability

FAAM:

Foot and Ankle Ability Measure

FAOS:

Foot and Ankle Outcome Score

FU:

Follow-up

ICRS:

International Cartilage Repair Society

NRS:

Numeric Rating Scale for Pain

OCLT:

Osteochondral lesion of the talus

PROM:

Patient-reported outcome measure 

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Acknowledgements

We want to thank the Deutsche Arthrose-Hilfe e.V. and the Stiftung Oskar-Helene-Heim.

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Authors and Affiliations

Authors

Contributions

MDA: study design, statistical data analysis and interpretation, drafting and writing the manuscript. MA: data acquisition and revision of the manuscript. CB: data acquisition and revision of the manuscript. AA: data acquisition and revision of the manuscript. SS: data acquisition and revision of the manuscript. MW: data acquisition and revision of the manuscript. OG: data acquisition and revision of the manuscript. SE: data acquisition and revision of the manuscript. WZ: data acquisition and revision of the manuscript. DK: study design, data acquisition, statistical data analysis and interpretation, drafting and writing the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Marc-Daniel Ahrend.

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Conflict of interest

OG received reimbursement of speaker fees and travel expenses from Geistlich Pharma AG. CP is a consultant of Medartis. CP or his institution received personal or scientific support from the following companies: Implantcast, Medartis, Stryker, DePuySynthes, Arthrex, OPED, Albrecht and Synthelix. There is no relevant conflict of interest regarding this paper. All other authors declare no potential conflict of interest.

Funding

The German Cartilage Registry is financially supported by the Deutsche Arthrose-Hilfe e.V. and the Stiftung Oskar-Helene-Heim.

Ethical approval

The data used in this study were obtained from the German Cartilage Registry (KnorpelRegister DGOU). Approval was given by the institutional review board (IRB) at every participating clinical centre. The identification number of the IRB of the study coordination centre at the University Hospital of Freiburg, Germany is B-F-2013-075#A1.

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Ahrend, MD., Aurich, M., Becher, C. et al. Preexisting and treated concomitant ankle instability does not compromise patient-reported outcomes of solitary osteochondral lesions of the talus treated with matrix-induced bone marrow stimulation in the first postoperative year: data from the German Cartilage Registry (KnorpelRegister DGOU). Knee Surg Sports Traumatol Arthrosc 30, 1187–1196 (2022). https://doi.org/10.1007/s00167-020-06172-5

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