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Release of growth factors after arthroscopic acromioplasty

  • Shoulder
  • Published:
Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

It has recently been postulated that a variety of growth factors may be released from cancellous bone after an acromioplasty. The aim of this study was to demonstrate the presence of growth factors in the subacromial space after acromioplasty. Between October 2006 and March 2007, 23 patients underwent arthroscopic acromioplasty. A sample of at least 3 ml of fluid from the shoulder was obtained 15 min after the end of the procedure. At the same time another sample of 3 ml of the patient’s venous blood was obtained as a control. The concentrations of growth factors in the fluids collected were determined using enzyme-linked immunosorbent assay (ELISA). The growth factors assayed were platelet-derived growth factor-AB (PDGF-AB), basic fibroblast growth factor basic (bFGF) and transforming growth factor beta 1 (TGF-β1). The concentrations of TGF-β1 (p = 0.0001), PDGF-AB (p = 0.02), and bFGF (p < 0.0001) were significantly higher in the fluid from the subacromial space than in the blood sample. There are high concentrations of several growth factors in the subacromial space after acromioplasty.

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Authors and Affiliations

  1. Dipartimento di Scienze Medico-Chirurgiche, Università degli Studi di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, Milan, Italy

    Pietro Randelli & Paolo Cabitza

  2. Facoltà di Scienze Motorie Università di Roma, Rome, Italy

    Fabrizio Margheritini

  3. Dipartimento di Tecnologie per la Vita, Facoltà di Medicina, Università degli Studi di Milano, Milan, Italy

    Giada Dogliotti & Massimiliano M. Corsi

  4. IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

    Massimiliano M. Corsi

  5. Istituto di Patologia Generale, Facoltà di Medicina, Università degli Studi di Milano, Milan, Italy

    Giada Dogliotti & Massimiliano M. Corsi

Authors
  1. Pietro Randelli
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  2. Fabrizio Margheritini
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  3. Paolo Cabitza
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  4. Giada Dogliotti
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  5. Massimiliano M. Corsi
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Correspondence to Pietro Randelli.

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Randelli, P., Margheritini, F., Cabitza, P. et al. Release of growth factors after arthroscopic acromioplasty. Knee Surg Sports Traumatol Arthr 17, 98–101 (2009). https://doi.org/10.1007/s00167-008-0653-4

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  • DOI: https://doi.org/10.1007/s00167-008-0653-4

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