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Data availability
The datasets analyzed during the current study are available from the corresponding author on reasonable request.
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Acknowledgements
We would like to thank the Sepsis Lung Microbiome Study Group members for their efforts: Beatriz Guillen-Guio, Tamara Hernandez-Beeftink, Laura Ciuffreda, Héctor Rodríguez-Pérez, Almudena Corrales, Carlos Flores: Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain; Tamara Hernandez-Beeftink, Jesús Villar: Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain; David Domínguez, David Viera Camacho, Gabriela Noemí González, Elena Espinosa, Department of Anesthesiology, Hospital Universitario N.S. de Candelaria, Santa Cruz de Tenerife, Spain; Adrian Baez-Ortega, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom; Almudena Corrales, Jesús Villar, Carlos Flores, CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Marina Soro: Department of Anesthesia, Critical Care and Pain Therapy. Hospital Clínico Universitario de Valencia, Valencia, Spain; Julia Alcoba-Florez: Department of Microbiology, Hospital Universitario N.S. de Candelaria, Santa Cruz de Tenerife, Spain; Rafaela González-Montelongo, Carlos Flores: Genomics Division, Instituto Tecnológico y de Energías Renovables (ITER), Santa Cruz de Tenerife, Spain; Jesús Villar: Keenan Research Center for Biomedical Sciences at the Knowledge Institute, St. Michael’s Hospital, Toronto, Canada; Carlos Flores: Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, Santa Cruz de Tenerife, Spain
Funding
Funded by Instituto de Salud Carlos III (PI14/00844; PI16/00049; PI17/00610; FI17/00177; FI18/00230), the Spanish Ministry of Science and Innovation (grant RTC-2017–6471-1; AEI/FEDER, UE), and co-financed by the European Regional Development Funds, “A way of making Europe” from the European Union, Cabildo Insular de Tenerife (CGIEU0000219140), Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFUN48/18); and by the agreement OA17/008 with Instituto Tecnológico y de Energías Renovables (ITER) to strengthen scientific and technological education, training, research, development and innovation in Genomics, Personalized Medicine and Biotechnology. BGG was supported by a fellowship from the ACIISI (TESIS2015010057) co-funded by European Social Fund.
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CF designed and supervised the study. BG-G, TH-B, LC, HR-P, AB-O, and RG-M performed the analyses and data interpretation. DD, AC, RH-B, JA, LS, DVC, GNG, MS, EE, JA-F, and JV participated in data acquisition. BG-G, LC, and CF wrote the draft of the manuscript. All authors contributed to the critical revision and final approval of the manuscript.
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The study was approved by the Research Ethics Committee of the hospital and performed according to The Code of Ethics of the World Medical Association (Declaration of Helsinki). An informed consent was obtained from all patients or from their legal representatives.
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The members of the Sepsis Lung Microbiome Study Group are listed in the Acknowledgements.
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Sepsis Lung Microbiome Study Group. Could lung bacterial dysbiosis predict ICU mortality in patients with extra-pulmonary sepsis? A proof-of-concept study. Intensive Care Med 46, 2118–2120 (2020). https://doi.org/10.1007/s00134-020-06190-4
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DOI: https://doi.org/10.1007/s00134-020-06190-4