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Prolonged elevation of plasma HMGB1 is associated with cognitive impairment in intensive care unit survivors

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Acknowledgements

We thank Caroline Keller, research nurse, for conducting CANTAB, and for the assistance with the patient follow-up. We thank Elisabeth Hellgren and Ola Friman, research nurses, for the assistance in patient recruitment and collection of blood samples.

HICUS study group includes: Caravaca A.S.: Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Solna; Karolinska Institute, Bioclinicum, Karolinska University Hospital, 171 76 Stockholm, Sweden. Gallina A.L.: Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Solna; Karolinska Institute, Bioclinicum, Karolinska University Hospital, 171 76 Stockholm, Sweden. Bottai M: Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institute, 171 77 Stockholm, Sweden. Eberhardson M.: Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Solna; Karolinska Institute, Bioclinicum, Karolinska University Hospital, 171 76 Stockholm, Sweden. Sundman E.: REMEO Stockholm, Torsten Levenstams väg 4, 128 64, Sköndal, Sweden; Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Solna, Karolinska Institute, Bioclinicum, Karolinska University Hospital, 171 76 Stockholm, Sweden.

Funding

This study was supported by a grant from the Knut and Alice Wallenberg Foundation, the Swedish Medical Council (Vetenskapsrådet), Olle Engkvist Research Foundation, Torsten Söderberg Foundation, Svenska Läkaresällskapet and the Stockholm City Council (ALF). The study sponsors played no role in the study design, data collection, data analysis, data interpretation, or writing of the report.

Author information

Authors and Affiliations

  1. Department of Physiology and Pharmacology, Karolinska Institute, 171 77, Stockholm, Sweden

    Emily Brück & Peter V. Sackey

  2. Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Solna, Karolinska Institute, Bioclinicum, Karolinska University Hospital, 171 76, Stockholm, Sweden

    Emily Brück & Peder S. Olofsson

  3. Stress Research Institute, Stockholm University, 106 91, Stockholm, Sweden

    Julie Lasselin

  4. Division of Psychology, Department of Clinical Neuroscience, Karolinska Institute, 171 77, Stockholm, Sweden

    Julie Lasselin

  5. Department of Women’s and Children’s Health, Karolinska Institute, 171 77, Stockholm, Sweden

    Ulf Andersson

  6. Laboratory of Biomedical Sciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Peder S. Olofsson

Authors
  1. Emily Brück
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  2. Julie Lasselin
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  3. Ulf Andersson
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  4. Peter V. Sackey
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  5. Peder S. Olofsson
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Consortia

The HICUS study group

  • A. S. Caravaca
  • , A. L. Gallina
  • , M. Bottai
  • , M. Eberhardson
  •  & E. Sundman

Corresponding author

Correspondence to Peder S. Olofsson.

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Conflicts of interest

No author declares any conflict of interest.

Ethics approval

The study was approved by the Regional Ethical Review Board in Stockholm (Approval number 2013/1221-31/1).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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The members of the HICUS study group are included in the acknowledgements section.

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Brück, E., Lasselin, J., The HICUS study group. et al. Prolonged elevation of plasma HMGB1 is associated with cognitive impairment in intensive care unit survivors. Intensive Care Med 46, 811–812 (2020). https://doi.org/10.1007/s00134-020-05941-7

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  • DOI: https://doi.org/10.1007/s00134-020-05941-7

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