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What’s new in the long-term neurodevelopmental outcome of critically ill children

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References

  1. Fivez T, Kerklaan D, Mesotten D, Verbruggen S, Wouters PJ, Vanhorebeek I, Debaveye Y, Vlasselaers D, Desmet L, Casaer MP et al (2016) Early versus late parenteral nutrition in critically ill children. N Engl J Med 374:1111–1122

    Article  PubMed  CAS  Google Scholar 

  2. Mesotten D, Gielen M, Sterken C, Claessens K, Hermans G, Vlasselaers D, Lemiere J, Lagae L, Gewillig M, Eyskens B et al (2012) Neurocognitive development of children 4 years after critical illness and treatment with tight glucose control: a randomized controlled trial. JAMA 308:1641–1650

    Article  PubMed  CAS  Google Scholar 

  3. Sterken CLJ, Vanhorebeek I, Van den Berghe G, Mesotten D (2015) Neurocognition after pediatric heart surgery: a systematic review and meta-analysis. Open Heart 2:e000255

    Article  PubMed  PubMed Central  Google Scholar 

  4. Madderom MJ, Reuser JJ, Utens EM, van Rosmalen J, Raets M, Govaert P, Steiner K, Gischler SJ, Tibboel D, van Heijst AF et al (2013) Neurodevelopmental, educational and behavioral outcome at 8 years after neonatal ECMO: a nationwide multicenter study. Intensive Care Med 39:1584–1593

    Article  PubMed  Google Scholar 

  5. Aspesberro F, Mangione-Smith R, Zimmerman JJ (2015) Health-related quality of life following pediatric critical illness. Intensive Care Med 41:1235–1246

    Article  PubMed  Google Scholar 

  6. Gaynor JW, Stopp C, Wypij D, Andropoulos DB, Atallah J, Atz AM, Beca J, Donofrio MT, Duncan K, Ghanayem NS et al (2015) Neurodevelopmental outcomes after cardiac surgery in infancy. Pediatrics 135:816–825

    Article  PubMed  PubMed Central  Google Scholar 

  7. Namachivayam SP, Alexander J, Slater A, Millar J, Erickson S, Tibballs J, Festa M, Ganu S, Segedin L, Schlapbach LJ et al (2015) Five-year survival of children with chronic critical illness in Australia and New Zealand. Crit Care Med 43:1978–1985

    Article  PubMed  Google Scholar 

  8. Als LC, Tennant A, Nadel S, Cooper M, Pierce CM, Garralda ME (2015) Persistence of neuropsychological deficits following pediatric critical illness. Crit Care Med 43:e312–e315

    Article  PubMed  Google Scholar 

  9. van Zellem L, Buysse C, Madderom M, Legerstee JS, Aarsen F, Tibboel D, Utens EM (2015) Long-term neuropsychological outcomes in children and adolescents after cardiac arrest. Intensive Care Med 41:1057–1066

    Article  PubMed  PubMed Central  Google Scholar 

  10. van Zellem L, Utens EM, de Wildt SN, Vet NJ, Tibboel D, Buysse C (2014) Analgesia-sedation in PICU and neurological outcome: a secondary analysis of long-term neuropsychological follow-up in meningococcal septic shock survivors. Pediatr Crit Care Med 15:189–196

    Article  PubMed  Google Scholar 

  11. Davidson AJ, Disma N, de Graaff JC, Withington DE, Dorris L, Bell G, Stargatt R, Bellinger DC, Schuster T, Arnup SJ et al (2016) Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet 387:239–250

    Article  PubMed  Google Scholar 

  12. Verstraete S, Vanhorebeek I, Covaci A, Güiza F, Malarvannan G, Jorens PG, Van den Berghe G (2015) Circulating phthalates during critical illness in children are associated with long-term attention deficit: a study of a development and a validation cohort. Intensive Care Med 42:379–392

    Article  PubMed  CAS  Google Scholar 

  13. Mittnacht J, Choukair D, Kneppo C, Brunner R, Parzer P, Gorenflo M, Bettendorf M (2015) Long-term neurodevelopmental outcome of children treated with tri-iodothyronine after cardiac surgery: follow-up of a double-blind, randomized, placebo-controlled study. Horm Res Paediatr 84:130–136

    Article  PubMed  CAS  Google Scholar 

  14. Wade SL, Zhang N, Yeates KO, Stancin T, Taylor HG (2016) Social environmental moderators of long-term functional outcomes of early childhood brain injury. JAMA Pediatr 170:343–349

    Article  PubMed  PubMed Central  Google Scholar 

  15. Curley MA, Wypij D, Watson RS, Grant MJ, Asaro LA, Cheifetz IM, Dodson BL, Franck LS, Gedeit RG, Angus DC et al (2015) Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. JAMA 313:379–389

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgements

This work was supported by the Research Foundation-Flanders (FWO), Belgium (FWO fellowship to SV); by the Methusalem program of the Flemish government (through the University of Leuven to GVdB, METH/08/07 and to GVdB and IV, METH/14/06); by an ERC Advanced Grant (AdvG-2012-321670) from the Ideas Program of the European Union 7th framework program to GVdB; and by the Institute for Science and Technology, Flanders, Belgium (through the University of Leuven to GVdB, IWT/070695/TBM).

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Authors and Affiliations

  1. Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium

    S. Verstraete, G. Van den Berghe & I. Vanhorebeek

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  1. S. Verstraete
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  2. G. Van den Berghe
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  3. I. Vanhorebeek
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Correspondence to I. Vanhorebeek.

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Verstraete, S., Van den Berghe, G. & Vanhorebeek, I. What’s new in the long-term neurodevelopmental outcome of critically ill children. Intensive Care Med 44, 649–651 (2018). https://doi.org/10.1007/s00134-017-4968-9

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  • DOI: https://doi.org/10.1007/s00134-017-4968-9

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