Skip to main content
Log in

What’s new in catheter-related infection: skin cleansing and skin antisepsis

  • What's New in Intensive Care
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Frasca D, Dahyot-Fizelier C, Mimoz O (2010) Prevention of central venous catheter-related infection in the intensive care unit. Crit Care 14:212

    Article  PubMed  PubMed Central  Google Scholar 

  2. Timsit JF, Mimoz O, Mourvillier B, Souweine B, Garrouste-Orgeas M, Alfandari S, Plantefeve G, Bronchard R, Troche G, Gauzit R, Antona M, Canet E, Bohe J, Lepape A, Vesin A, Arrault X, Schwebel C, Adrie C, Zahar JR, Ruckly S, Tournegros C, Lucet JC (2012) Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults. Am J Respir Crit Care Med 186:1272–1278

    Article  CAS  PubMed  Google Scholar 

  3. Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S (2002) Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med 136:792–801

    Article  CAS  PubMed  Google Scholar 

  4. Parienti JJ, du Cheyron D, Ramakers M, Malbruny B, Leclercq R, Le Coutour X, Charbonneau P, Members of the NACRE Study Group (2004) Alcoholic povidone-iodine to prevent central venous catheter colonization: a randomized unit-crossover study. Crit Care Med 32:708–713

    Article  CAS  PubMed  Google Scholar 

  5. Chopra V, Shojania KG (2013) Recipes for checklists and bundles: one part active ingredient, two parts measurement. BMJ Qual Saf 22:93–96

    Article  PubMed  Google Scholar 

  6. Mimoz O, Villeminey S, Ragot S, Dahyot-Fizelier C, Laksiri L, Petitpas F, Debaene B (2007) Chlorhexidine-based antiseptic solution versus alcohol-based povidone-iodine for central venous catheter care. Arch Intern Med 167:2066–2072

    Article  CAS  PubMed  Google Scholar 

  7. Girard R, Comby C, Jacques D (2012) Alcoholic povidone-iodine or chlorhexidine-based antiseptic for the prevention of central venous catheter-related infections: in-use comparison. J Infect Public Health 5:35–42

    Article  PubMed  Google Scholar 

  8. O’Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph AG, Rupp ME, Saint S, Healthcare Infection Control Practices Advisory Committee (HICPAC) (2011) Summary of recommendations: guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 52:1087–1099

    Article  PubMed  PubMed Central  Google Scholar 

  9. Loveday HP, Wilson JA, Pratt RJ, Golsorkhi M, Tingle A, Bak A, Browne J, Prieto J, Wilcox M, UK Department of Health (2014) Epic3: national evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England. J Hosp Infect 86(Suppl 1):S1–S70

    Article  PubMed  Google Scholar 

  10. Société française d’anesthésie et de réanimation, Société de réanimation de langue française (2009) Prevention of hospital-acquired sepsis in intensive care unit (except cross transmission and neonate). Ann Fr Anesth Reanim 28:912–920

    Article  Google Scholar 

  11. Zamora JL, Price MF, Chuang P, Gentry LO (1985) Inhibition of povidone-iodine’s bactericidal activity by common organic substances: an experimental study. Surgery 98:25–29

    CAS  PubMed  Google Scholar 

  12. Mimoz O, Lucet JC, Kerforne T, Pascal J, Souweine B, Goudet V, Mercat A, Bouadma L, Lasocki S, Alfandari S, Friggeri A, Wallet F, Allou N, Ruckly S, Balayn D, Lepape A, Timsit JF, CLEAN trial investigators (2015) Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial. Lancet 386:2069–2077

    Article  CAS  PubMed  Google Scholar 

  13. Schwebel C, Lucet JC, Vesin A, Arrault X, Calvino-Gunther S, Bouadma L, Timsit JF (2012) Economic evaluation of chlorhexidine-impregnated sponges for preventing catheter-related infections in critically ill adults in the dressing study. Crit Care Med 40:11–17

    Article  PubMed  Google Scholar 

  14. Casey A, Itrakjy A, Birkett C, Clethro A, Bonser R, Graham T, Mascaro J, Pagano D, Rooney S, Wilson I, Nightingale P, Crosby C, Elliott T (2015) A comparison of the efficacy of 70 % v/v isopropyl alcohol with either 0.5 % w/v or 2 % w/v chlorhexidine gluconate for skin preparation before harvest of the long saphenous vein used in coronary artery bypass grafting. Am J Infect Control 43:816–820

    Article  CAS  PubMed  Google Scholar 

  15. Milstone AM, Passaretti CL, Perl TM (2008) Chlorhexidine: expanding the armamentarium for infection control and prevention. Clin Infect Dis 46:274–281

    Article  PubMed  Google Scholar 

  16. Dettenkofer M, Wilson C, Gratwohl A, Schmoor C, Bertz H, Frei R, Heim D, Luft D, Schulz S, Widmer AF (2010) Skin disinfection with octenidine dihydrochloride for central venous catheter site care: a double-blind, randomized, controlled trial. Clin Microbiol Infect 16:600–606

    Article  CAS  PubMed  Google Scholar 

  17. Bilir A, Yelken B, Erkan A (2013) Chlorhexidine, octenidine or povidone iodine for catheter-related infections: a randomized controlled trial. J Res Med Sci 18:510–512

    PubMed  PubMed Central  Google Scholar 

  18. Forni C, Sabattini T, D’Alessandro F, Fiorani A, Gamberini S, Maso A, Curci R, Zanotti E, Chiari P (2015) Use of sodium hypochlorite for skin antisepsis before inserting a peripheral venous catheter: a pilot study. Biol Res Nurs 17:330–333

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Olivier Mimoz.

Ethics declarations

Conflicts of interest

OM received research grants, lecture, and consultancy fees from CareFusion. VC is supported by a career development award from the Agency for Healthcare Quality Research. JFT received research grants from 3M Company.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mimoz, O., Chopra, V. & Timsit, JF. What’s new in catheter-related infection: skin cleansing and skin antisepsis. Intensive Care Med 42, 1784–1786 (2016). https://doi.org/10.1007/s00134-016-4244-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-016-4244-4

Keywords

Navigation