References
Frasca D, Dahyot-Fizelier C, Mimoz O (2010) Prevention of central venous catheter-related infection in the intensive care unit. Crit Care 14:212
Timsit JF, Mimoz O, Mourvillier B, Souweine B, Garrouste-Orgeas M, Alfandari S, Plantefeve G, Bronchard R, Troche G, Gauzit R, Antona M, Canet E, Bohe J, Lepape A, Vesin A, Arrault X, Schwebel C, Adrie C, Zahar JR, Ruckly S, Tournegros C, Lucet JC (2012) Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults. Am J Respir Crit Care Med 186:1272–1278
Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S (2002) Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med 136:792–801
Parienti JJ, du Cheyron D, Ramakers M, Malbruny B, Leclercq R, Le Coutour X, Charbonneau P, Members of the NACRE Study Group (2004) Alcoholic povidone-iodine to prevent central venous catheter colonization: a randomized unit-crossover study. Crit Care Med 32:708–713
Chopra V, Shojania KG (2013) Recipes for checklists and bundles: one part active ingredient, two parts measurement. BMJ Qual Saf 22:93–96
Mimoz O, Villeminey S, Ragot S, Dahyot-Fizelier C, Laksiri L, Petitpas F, Debaene B (2007) Chlorhexidine-based antiseptic solution versus alcohol-based povidone-iodine for central venous catheter care. Arch Intern Med 167:2066–2072
Girard R, Comby C, Jacques D (2012) Alcoholic povidone-iodine or chlorhexidine-based antiseptic for the prevention of central venous catheter-related infections: in-use comparison. J Infect Public Health 5:35–42
O’Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph AG, Rupp ME, Saint S, Healthcare Infection Control Practices Advisory Committee (HICPAC) (2011) Summary of recommendations: guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 52:1087–1099
Loveday HP, Wilson JA, Pratt RJ, Golsorkhi M, Tingle A, Bak A, Browne J, Prieto J, Wilcox M, UK Department of Health (2014) Epic3: national evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England. J Hosp Infect 86(Suppl 1):S1–S70
Société française d’anesthésie et de réanimation, Société de réanimation de langue française (2009) Prevention of hospital-acquired sepsis in intensive care unit (except cross transmission and neonate). Ann Fr Anesth Reanim 28:912–920
Zamora JL, Price MF, Chuang P, Gentry LO (1985) Inhibition of povidone-iodine’s bactericidal activity by common organic substances: an experimental study. Surgery 98:25–29
Mimoz O, Lucet JC, Kerforne T, Pascal J, Souweine B, Goudet V, Mercat A, Bouadma L, Lasocki S, Alfandari S, Friggeri A, Wallet F, Allou N, Ruckly S, Balayn D, Lepape A, Timsit JF, CLEAN trial investigators (2015) Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial. Lancet 386:2069–2077
Schwebel C, Lucet JC, Vesin A, Arrault X, Calvino-Gunther S, Bouadma L, Timsit JF (2012) Economic evaluation of chlorhexidine-impregnated sponges for preventing catheter-related infections in critically ill adults in the dressing study. Crit Care Med 40:11–17
Casey A, Itrakjy A, Birkett C, Clethro A, Bonser R, Graham T, Mascaro J, Pagano D, Rooney S, Wilson I, Nightingale P, Crosby C, Elliott T (2015) A comparison of the efficacy of 70 % v/v isopropyl alcohol with either 0.5 % w/v or 2 % w/v chlorhexidine gluconate for skin preparation before harvest of the long saphenous vein used in coronary artery bypass grafting. Am J Infect Control 43:816–820
Milstone AM, Passaretti CL, Perl TM (2008) Chlorhexidine: expanding the armamentarium for infection control and prevention. Clin Infect Dis 46:274–281
Dettenkofer M, Wilson C, Gratwohl A, Schmoor C, Bertz H, Frei R, Heim D, Luft D, Schulz S, Widmer AF (2010) Skin disinfection with octenidine dihydrochloride for central venous catheter site care: a double-blind, randomized, controlled trial. Clin Microbiol Infect 16:600–606
Bilir A, Yelken B, Erkan A (2013) Chlorhexidine, octenidine or povidone iodine for catheter-related infections: a randomized controlled trial. J Res Med Sci 18:510–512
Forni C, Sabattini T, D’Alessandro F, Fiorani A, Gamberini S, Maso A, Curci R, Zanotti E, Chiari P (2015) Use of sodium hypochlorite for skin antisepsis before inserting a peripheral venous catheter: a pilot study. Biol Res Nurs 17:330–333
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OM received research grants, lecture, and consultancy fees from CareFusion. VC is supported by a career development award from the Agency for Healthcare Quality Research. JFT received research grants from 3M Company.
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Mimoz, O., Chopra, V. & Timsit, JF. What’s new in catheter-related infection: skin cleansing and skin antisepsis. Intensive Care Med 42, 1784–1786 (2016). https://doi.org/10.1007/s00134-016-4244-4
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DOI: https://doi.org/10.1007/s00134-016-4244-4