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Understanding toxic shock syndrome

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References

  1. DeVries AS, Lesher L, Schlievert PM, Rogers T, Villaume LG, Danila R, Lynfield R (2011) Staphylococcal toxic shock syndrome 2000–2006: epidemiology, clinical features, and molecular characteristics. PLoS One 6:e22997

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Lamagni TL, Darenberg J, Luca-Harari B, Siljander T, Efstratiou A, Henriques-Normark B, Vuopio-Varkila J, Bouvet A, Creti R, Ekelund K, Koliou M, Reinert RR, Stathi A, Strakova L, Ungureanu V, Schalen C, Jasir A (2008) Epidemiology of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol 46:2359–2367

    Article  PubMed Central  PubMed  Google Scholar 

  3. Kain KC, Schulzer M, Chow AW (1993) Clinical spectrum of nonmenstrual toxic shock syndrome (TSS): comparison with menstrual TSS by multivariate discriminant analyses. Clin Infect Dis 16:100–106

    Article  CAS  PubMed  Google Scholar 

  4. Descloux E, Perpoint T, Ferry T, Lina G, Bes M, Vandenesch F, Mohammedi I, Etienne J (2008) One in five mortality in non-menstrual toxic shock syndrome versus no mortality in menstrual cases in a balanced French series of 55 cases. Eur J Clin Microbiol Infect Dis 27:37–43

    Article  CAS  PubMed  Google Scholar 

  5. Hajjeh RA, Reingold A, Weil A, Shutt K, Schuchat A, Perkins BA (1999) Toxic shock syndrome in the United States: surveillance update, 1979 1996. Emerg Infect Dis 5:807–810

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Centers for Disease Control and Prevention (2011) Toxic shock syndrome (other than streptococcal) (TSS); 2011 case definition. http://wwwn.cdc.gov/nndss/conditions/toxic-shock-syndrome-other-than-streptococcal/case-definition/2011/. Accessed 3 Apr 2015

  7. Parsonnet J, Hansmann MA, Delaney ML, Modern PA, Dubois AM, Wieland-Alter W, Wissemann KW, Wild JE, Jones MB, Seymour JL, Onderdonk AB (2005) Prevalence of toxic shock syndrome toxin 1-producing Staphylococcus aureus and the presence of antibodies to this superantigen in menstruating women. J Clin Microbiol 43:4628–4634

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Davies HD, McGeer A, Schwartz B, Green K, Cann D, Simor AE, Low DE (1996) Invasive group A streptococcal infections in Ontario, Canada. Ontario Group A Streptococcal Study Group. N Engl J Med 335:547–554

    Article  CAS  PubMed  Google Scholar 

  9. Centers for Disease Control and Prevention (2010) Streptococcal toxic-shock syndrome (STSS) (Streptococcus pyogenes); 2010 case definition. http://wwwn.cdc.gov/nndss/conditions/streptococcal-toxic-shock-syndrome/case-definition/2010/. Accessed 3 Apr 2015

  10. Holm SE, Norrby A, Bergholm AM, Norgren M (1992) Aspects of pathogenesis of serious group A streptococcal infections in Sweden, 1988–1989. J Infect Dis 166:31–37

    Article  CAS  PubMed  Google Scholar 

  11. Miller LG, Perdreau-Remington F, Rieg G, Mehdi S, Perlroth J, Bayer AS, Tang AW, Phung TO, Spellberg B (2005) Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med 352:1445–1453

    Article  CAS  PubMed  Google Scholar 

  12. Schlievert PM (1986) Staphylococcal enterotoxin B and toxic-shock syndrome toxin-1 are significantly associated with non-menstrual TSS. Lancet 1:1149–1150

    Article  CAS  PubMed  Google Scholar 

  13. Lee VT, Chang AH, Chow AW (1992) Detection of staphylococcal enterotoxin B among toxic shock syndrome (TSS)- and non-TSS-associated Staphylococcus aureus isolates. J Infect Dis 166:911–915

    Article  CAS  PubMed  Google Scholar 

  14. Stevens DL, Wallace RJ, Hamilton SM, Bryant AE (2006) Successful treatment of staphylococcal toxic shock syndrome with linezolid: a case report and in vitro evaluation of the production of toxic shock syndrome toxin type 1 in the presence of antibiotics. Clin Infect Dis 42:729–730

    Article  PubMed  Google Scholar 

  15. Carapetis JR, Jacoby P, Carville K, Ang SJ, Curtis N, Andrews R (2014) Effectiveness of clindamycin and intravenous immunoglobulin, and risk of disease in contacts, in invasive group a streptococcal infections. Clin Infect Dis 59:358–365

    Article  CAS  PubMed  Google Scholar 

  16. Stevens DL, Ma Y, Salmi DB, McIndoo E, Wallace RJ, Bryant AE (2007) Impact of antibiotics on expression of virulence-associated exotoxin genes in methicillin-sensitive and methicillin-resistant Staphylococcus aureus. J Infect Dis 195:202–211

    Article  CAS  PubMed  Google Scholar 

  17. Coyle EA, Cha R, Rybak MJ (2003) Influences of linezolid, penicillin, and clindamycin, alone and in combination, on streptococcal pyrogenic exotoxin a release. Antimicrob Agents Chemother 47:1752–1755

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. Darenberg J, Ihendyane N, Sjolin J, Aufwerber E, Haidl S, Follin P, Andersson J, Norrby-Teglund A (2003) Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. Clin Infect Dis 37:333–340

    Article  CAS  PubMed  Google Scholar 

  19. Linner A, Darenberg J, Sjolin J, Henriques-Normark B, Norrby-Teglund A (2014) Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study. Clin Infect Dis 59:851–857

    Article  CAS  PubMed  Google Scholar 

  20. Matsushima A, Kuroki Y, Nakajima S, Sakai T, Kojima H, Ueyama M (2014) Low level of TSST-1 antibody in burn patients with toxic shock syndrome caused by methicillin-resistant Staphylococcus aureus. J Burn Care Res. doi:10.1097/BCR.0000000000000128

    Google Scholar 

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Conflicts of interest

Dr. Burnham has no conflicts of interest to report. Dr. Kollef’s effort was supported by the Barnes-Jewish Hospital Foundation.

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Correspondence to Marin H. Kollef.

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This work was performed at Barnes-Jewish Hospital, St. Louis, MO.

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Burnham, J.P., Kollef, M.H. Understanding toxic shock syndrome. Intensive Care Med 41, 1707–1710 (2015). https://doi.org/10.1007/s00134-015-3861-7

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  • DOI: https://doi.org/10.1007/s00134-015-3861-7

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