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Understanding infection susceptibility in patients with acute-on-chronic liver failure

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References

  1. Bajaj J, O’Leary J, Reddy K, Wong F, Olson J, Subramanian R, Brown G, Noble N, Thacker L, Kamath P (2012) Second infections independently increase mortality in hospitalized cirrhotic patients: the NACSELD experience. Hepatology 56(6):2328–2335. doi:10.1002/hep.25947

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, Durand F, Gustot T, Saliba F, Domenicali M, Gerbes A, Wendon J, Alessandria C, Laleman W, Zeuzem S, Trebicka J, Bernardi M, Arroyo V, CANONIC Study Investigators of the EASL-CLIF Consortium (2013) Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology 144(7):1426–1437. doi:10.1053/j.gastro.2013.02.042 (Epub)

    Article  PubMed  Google Scholar 

  3. Antonelli M, Bonten M, Chastre J, Citerio G, Conti G, Curtis JR, De Backer D, Hedenstierna G, Joannidis M, Macrae D, Mancebo J, Maggiore S, Mebazaa A, Presier JC, Rocco P, Timsit JF, Wenerman J, Zhang H (2012) Year in review in Intensive Care Medicine 2011. II. Cardiovascular, infections, pneumonia and sepsis, critical care organization and outcome, education, ultrasonography, metabolism and coagulation. Intensive Care Med 38:345–358. doi:10.1007/s00134-012-2467-6

    Article  PubMed Central  PubMed  Google Scholar 

  4. Bellot P, Frances R, Such J (2012) Pathological bacterial translocation in cirrhosis: pathophysiology, diagnosis and clinical implications. Liver Int 33(1):31–39. doi:10.1111/liv.12021 (Epub)

    Article  PubMed  Google Scholar 

  5. Seki E, Schnabl B (2011) Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut. J Physiol 590(Pt 3):447–458. doi:10.1113/jphysiol.2011.219691 (Epub)

    PubMed Central  PubMed  Google Scholar 

  6. Mookerjee R (2011) Acute-on-chronic liver failure: the liver and portal haemodynamics. Curr Opin Crit Care 17(2):170–176. doi:10.1097/MCC.0b013e328344a076

    Article  PubMed  Google Scholar 

  7. Verbeke L, Nevens F, Laleman W (2011) Bench-to-beside review: acute-on-chronic liver failure-linking the gut, liver and systemic circulation. Crit Care 15(5):233. doi:10.1186/cc10424 (Epub)

    Article  PubMed Central  PubMed  Google Scholar 

  8. Holland-Fishcer P, Grønbæk H, Sandahl TD, Moestrup S, Riggio O, Ridola L, Aagaard N, Møller H, Vilstrup H (2011) Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS. Gut 60:1389–1393

    Article  Google Scholar 

  9. Edwards L, Wanless IR (2013) Mechanisms of liver involvement in systemic disease. Best Pract Res Clin Gastroenterol 27(4):471–483. doi:10.1016/j.bpg.2013.08.002 (Epub)

    Article  CAS  PubMed  Google Scholar 

  10. Zou Z, Xu D, Li B, Xin S, Zhang Z, Huang L, Fu J, Yang Y, Jin L, Zhao JM, Shi M, Zhou G, Sun Y, Wang FS (2009) Compartmentalization and its implication for peripheral immunologically-competent cells to the liver in patients with HBV-related acute-on-chronic liver failure. Hepatol Res 39(12):1198–1207. doi:10.1111/j.1872-034X.2009.00571.x (Epub)

    Article  CAS  PubMed  Google Scholar 

  11. Shawcross D, Wright G, Stadlbauer V, Hodges S, Davies N, Wheeler-Jones C, Pitsillides A, Jalan R (2008) Ammonia impairs neutrophil phagocytic function in liver disease. Hepatology 48(4):1202–1212. doi:10.1002/hep.22474

    Article  CAS  PubMed  Google Scholar 

  12. Wasmuth H, Kunz D, Yagmur E, Timmer-Stranghöner A, Vidacek D, Siewert E, Bach J, Geier A, Purucker E, Gressner A, Matern S, Lammert F (2005) Patients with acute on chronic liver failure display “sepsis-like” immune paralysis. J Hepatol 42(2):195–201

    Article  CAS  PubMed  Google Scholar 

  13. Berry P, Antoniades C, Carey I, McPhail M, Hussain M, Davies E, Wendon J, Vergani D (2010) Severity of the compensatory anti-inflammatory response determined by monocyte HLA-DR expression may assist outcome prediction in cirrhosis. Intensive Care Med 37(3):453–460. doi:10.1007/s00134-010-2099-7

    Article  PubMed  Google Scholar 

  14. Dong X, Gong Y, Zeng H, Hao Y, Wang X, Hou J, Wang J, Li J, Zhu Y, Liu H, Han J, Zhou H, Shen L, Gao T, Zhou T, Yang S, Li S, Chen Y, Meng Q, Li H (2013) Imbalance between circulating CD4+ regulatory T and conventional T lymphocytes in patients with HBV-related acute-on-chronic liver failure. Liver Int 33(10):1517–1526. doi:10.1111/liv.12248

    CAS  PubMed  Google Scholar 

  15. Yang J, Yi P, Wei L, Xu Z, Chen Y, Tang L, Li L (2012) Phenotypes and clinical significance of circulating CD4+CD25+ regulatory T cells (Tregs) in patients with acute-on-chronic liver failure (ACLF). J Transl Med 15(10):193. doi:10.1186/1479-5876-10-193

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Hepatology, St Mary’s Hospital, London, UK

    Nowlan Selvapatt & Charalambos Gustav Antoniades

  2. Liver Intensive Care Unit, King’s College Hospital, London, UK

    Arjuna Singanayagam & Julia Wendon

Authors
  1. Nowlan Selvapatt
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  2. Arjuna Singanayagam
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  3. Julia Wendon
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  4. Charalambos Gustav Antoniades
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Correspondence to Nowlan Selvapatt.

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Selvapatt, N., Singanayagam, A., Wendon, J. et al. Understanding infection susceptibility in patients with acute-on-chronic liver failure. Intensive Care Med 40, 1363–1366 (2014). https://doi.org/10.1007/s00134-014-3349-x

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  • DOI: https://doi.org/10.1007/s00134-014-3349-x

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