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Long-term mortality and quality of life after septic shock: a follow-up observational study

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Abstract

Purpose

In septic shock, short-term outcomes are frequently reported, while long-term outcomes are not. The aim of this study was to evaluate mortality and health-related quality of life (HRQOL) in survivors 6 months after an episode of septic shock.

Methods

This single-centre observational study was conducted in an intensive care unit in a university hospital. All patients with septic shock were included. Mortality was assessed 6 months after the onset of septic shock, and a comparison between patients who survived and those who died was performed. HRQOL was assessed using the MOS SF-36 questionnaire prior to hospital admission (baseline) and at 6 months in survivors. HRQOL at baseline and at 6 months were compared to the general French population, and HRQOL at baseline was compared to 6-month HRQOL.

Results

Ninety-six patients were included. Six-month mortality was 45 %. Survivors were significantly younger, had significantly lower lactate levels and SAPS II scores, required less renal support, received less frequent administration of corticosteroids, and had a longer length of hospital stay. At baseline (n = 39) and 6 months (n = 46), all of the components of the SF-36 questionnaire were significantly lower than those in the general population. Compared to baseline (n = 23), the Physical Component Score (CS) improved significantly at 6 months, the Mental CS did not differ.

Conclusions

Mortality 6 months after septic shock was high. HRQOL at baseline was impaired when compared to that of the general population. Although improvements were noted at 6 months, HRQOL remained lower than that in the general population.

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Acknowledgments

The authors are grateful to Jean-Vincent Frénel, (Département d’Anesthésie-Réanimation 1; Hôpital Pontchaillou, France) for designing the figures.

Funding

None.

Conflicts of interest

The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Département d’Anesthésie-Réanimation 1, Inserm U991, Service de Réanimation Chirurgicale, Hôpital Pontchaillou, Université Rennes 1, 2 rue Henri Le Guilloux, 35033, Rennes Cedex 9, France

    Nicolas Nesseler, Anne Defontaine, Yoann Launey, Yannick Mallédant & Philippe Seguin

  2. Centre d’Investigation Clinique; Inserm 0203, Hôpital Pontchaillou, 2 rue Henri Le Guilloux, 35033, Rennes Cedex 9, France

    Jeff Morcet

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  1. Nicolas Nesseler
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  2. Anne Defontaine
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Correspondence to Nicolas Nesseler.

Additional information

Presented in part at the 2012 54th Annual Congress of the French Society of Anaesthesiology and Intensive Care Medicine (Société Française d’Anesthésie-Réanimation, SFAR), Paris, France, 19–22 September.

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Nesseler, N., Defontaine, A., Launey, Y. et al. Long-term mortality and quality of life after septic shock: a follow-up observational study. Intensive Care Med 39, 881–888 (2013). https://doi.org/10.1007/s00134-013-2815-1

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  • DOI: https://doi.org/10.1007/s00134-013-2815-1

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