Abstract
Purpose
To assess the prevalence and predictive value of natural autoantibodies to high-mobility group box 1 (HMGB1) during sepsis.
Methods
Anti-HMGB1 and anti-human serum albumin (HSA) autoantibodies were detected by ELISA in 178 plasma samples longitudinally collected from 40 critically ill patients with septic shock. One hundred thirty-two plasma samples from healthy donors were used as control.
Results
IgGs to HMGB1 were detected in 15/40 patients (37.5%). The prevalence of anti-HMGB1 antibodies was significantly higher in the patients who survived (55%) compared to the patients who did not (20%) (p < 0.0001). The detection of anti-HMGB1 antibodies during the course of the disease was significantly associated with patient survival (p = 0.038). Moreover, there is a progressive and significant emergence of anti-HMGB1 antibodies during the course of the disease, mostly in patients who survived.
Conclusions
This study shows that autoantibodies to HMGB1 are produced during sepsis and are associated with a favorable outcome in patients undergoing septic shock.
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Acknowlegdments
CB received a PhD fellowship from the Ministère de l’Enseignement Supérieur et de la Recherche français, from the Réseau Herpesvirus et Cancer and from La Ligue contre le Cancer. SBV is indebted to Mélanie Messmer for her helpful discussions and constant support. The authors are grateful to Dr. Joel Gozlan for comments and fruitful discussions.
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All authors certify that there is no conflict of interest.
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V. Maréchal and S. Gibot share the seniorship position.
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Barnay-Verdier, S., Fattoum, L., Borde, C. et al. Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock. Intensive Care Med 37, 957–962 (2011). https://doi.org/10.1007/s00134-011-2192-6
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DOI: https://doi.org/10.1007/s00134-011-2192-6