Skip to main content
SpringerLink
Log in

Outcome of acute kidney injury in severe burns: a systematic review and meta-analysis

  • Review
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

Abstract

Purpose

The main objective of this review was to analyse the prevalence and outcome of acute kidney injury (AKI) in patients with severe burn injury. AKI is a common complication in patients with severe burn injury and one of the major causes of death (often combined with other organ dysfunctions). Several definitions of AKI have been used, but the RIFLE ‘consensus’ classification is nowadays considered the gold standard, enabling a more objective comparison of populations.

Methods

We performed a systematic literature search (1960–2009), involving PubMed, the Web of Science, the search engine Google™ and textbooks. Reference lists and the Science Citation Index search were also consulted. Attributable mortality was assessed by performing a meta-analysis.

Results

This search yielded 57 articles and abstracts with relevant epidemiologic data of AKI in the burn population. Of these, 30 contained complete mortality data of the burn and control population, which revealed a 3- to 6-fold higher mortality for AKI patients in univariate analysis, depending on the applied definition. When defined by the RIFLE consensus classification, AKI occurred in one quarter of patients with severe burn injury (median mortality of 34.9%), and when defined by the need for renal replacement therapy (RRT), AKI occurred in 3% (median mortality of 80%). The prevalence of AKI slightly increased, but AKI-RRT decreased. However, the outcome in both groups improved.

Conclusion

Despite the wide variation of the analysed burn populations and definitions of AKI, this review clearly showed that AKI remains prevalent and is associated with increased mortality in patients with severe burn injury.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Stephens FO, Stewart JH (1965) Burns complicated by anuria: recovery after radical surgery and haemodialysis. Lancet 15–17

  2. Stewart JH, Stephens FO (1965) Burns complicated by anuria. Lancet 286:1131

    Article  Google Scholar 

  3. Goldsmith HJ, Nakamoto S, Kolff WJ (1960) Expanding the indications for treatment with the artificial kidney: burns, cerebral oedema, sulphonamide intoxication and congestive heart-failure. Lancet 111–112

  4. Creyssel J, Deleuze R, Gate A, Caillard B (1962) Renal function in a burned patient. Study of 430 cases. Lyon Chir 58:137–141

    CAS  PubMed  Google Scholar 

  5. Hockmuth RE, Ziffren SE (1963) Results of the treatment of severe burns. Surg Gynecol Obstet 117:540–546

    CAS  PubMed  Google Scholar 

  6. Proyard G, Cuypers Y (1963) Renal insufficiency in burned patients. Acta Chir Belg 62:510–516

    CAS  PubMed  Google Scholar 

  7. Fitzwater J, Purdue GF, Hunt JL, O’Keefe GE (2003) The risk factors and time course of sepsis and organ dysfunction after burn trauma. J Trauma 54:959–966

    Article  PubMed  Google Scholar 

  8. Blot S (2009) Development and validation of a model for prediction of mortality in patients with acute burn injury. Br J Surg 96:111–117

    Article  Google Scholar 

  9. Colpaert K, Hoste EA (2008) Acute kidney injury in burns: a story of volume and inflammation. Crit Care 12:192

    Article  PubMed  Google Scholar 

  10. Brusselaers N, Hoste EA, Monstrey S, Colpaert KE, De Waele JJ, Vandewoude KH, Blot SI (2005) Outcome and changes over time in survival following severe burns from 1985 to 2004. Intensive Care Med 31:1648–1653

    Article  PubMed  Google Scholar 

  11. Brusselaers N, Juhasz I, Erdei I, Monstrey S, Blot S (2009) Evaluation of mortality following severe burns injury in hungary: external validation of a prediction model developed on belgian burn data. Burns 35(7):1009–1014. doi:10.1016/j.burns.2008.1012.1017

    Article  CAS  PubMed  Google Scholar 

  12. Cumming J, Purdue GF, Hunt JL, O’Keefe GE (2001) Objective estimates of the incidence and consequences of multiple organ dysfunction and sepsis after burn trauma. J Trauma 50:510–515

    Article  CAS  PubMed  Google Scholar 

  13. Langenberg C, Wan L, Egi M, May CN, Bellomo R (2006) Renal blood flow in experimental septic acute renal failure. Kidney Int 69:1996–2002

    Article  CAS  PubMed  Google Scholar 

  14. Wan L, Bellomo R, Di Giantomasso D, Ronco C (2003) The pathogenesis of septic acute renal failure. Curr Opin Crit Care 9:496–502

    Article  PubMed  Google Scholar 

  15. Tuggle D, Skinner S, Garza J, Vandijck D, Blot S (2007) The abdominal compartment syndrome in patients with burn injury. Acta Clin Belg Suppl 1:136–140

    PubMed  Google Scholar 

  16. Jeschke MG, Mlcak RP, Finnerty CC, Norbury WB, Gauglitz GG, Kulp GA, Herndon DN (2007) Burn size determines the inflammatory and hypermetabolic response. Crit Care 11:R90

    Article  PubMed  Google Scholar 

  17. Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, De Bacquer D, Kellum JA (2006) RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 10:R73

    Article  PubMed  Google Scholar 

  18. Kellum JA, Hoste EA (2008) Acute kidney injury: epidemiology and assessment. Scand J Clin Lab Invest Suppl 241:6–11

    Article  PubMed  Google Scholar 

  19. Palevsky PM (2006) Dialysis modality and dosing strategy in acute renal failure. Semin Dial 19:165–170

    Article  PubMed  Google Scholar 

  20. Hoste EA, Schurgers M (2008) Epidemiology of acute kidney injury: how big is the problem? Crit Care Med 36:S146–S151

    Article  PubMed  Google Scholar 

  21. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the second international consensus conference of the acute dialysis quality initiative (ADQI) group. Crit Care 8:R204–R212

    Article  PubMed  Google Scholar 

  22. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A (2007) Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11:R31

    Article  PubMed  Google Scholar 

  23. Bagshaw SM, George C, Dinu I, Bellomo R (2008) A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients. Nephrol Dial Transplant 23:1203–1210

    Article  PubMed  Google Scholar 

  24. Mariano F, Gangemi EN, Stella M, Tedeschi L, Gregoretti C, Triolo G (2009) Critical care nephrology: Chapter 57: Burns and acute renal failure, 2nd edn. Saunders-Elsevier, Philadelphia

    Google Scholar 

  25. Herndon DN (2007) Total burn care, 3rd edn. Saunders-Elsevier, Galveston

    Google Scholar 

  26. Altman DG (2001) Systematic reviews of evaluations of prognostic variables. BMJ 323:224–228

    Article  CAS  PubMed  Google Scholar 

  27. Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:doi:10/1371/journal.pmed.1000097

  28. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 283:2008–2012

    Article  CAS  PubMed  Google Scholar 

  29. Sabry A, Wafa I, El-Din AB, El-Hadidy AM, Hassan M (2009) Early markers of renal injury in predicting outcome in thermal burn patients. Saudi J Kidney Dis Transpl 20:632–638

    PubMed  Google Scholar 

  30. Chung KK, Juncos LA, Wolf SE, Mann EE, Renz EM, White CE, Barillo DJ, Clark RA, Jones JA, Edgecombe HP, Park MS, Albrecht MC, Cancio LC, Wade CE, Holcomb JB (2008) Continuous renal replacement therapy improves survival in severely burned military casualties with acute kidney injury. J Trauma 64:S179–S185 (discussion S185–177)

    Article  PubMed  Google Scholar 

  31. Jeschke MG, Barrow RE, Wolf SE, Herndon DN (1998) Mortality in burned children with acute renal failure. Arch Surg 133:752–756

    Article  CAS  PubMed  Google Scholar 

  32. Cason JS (1965) Treatment of renal failure in burns. In: Transactions of 2nd international congress on research in burns Edinburgh, Livingstone. 12

  33. Gudaviciene D, Rimdeika R, Adamonis K (2004) Influence of enteral nutrition on the frequency of complications in case of major burns. Medicina (Kaunas) 40:957–961

    Google Scholar 

  34. O’Keefe GE, Hunt JL, Purdue GF (2001) An evaluation of risk factors for mortality after burn trauma and the identification of gender-dependent differences in outcomes. J Am Coll Surg 192:153–160

    Article  PubMed  Google Scholar 

  35. Rohan JE, Beaufils H, Chapman A (1972) Acute renal failure during the first 3 months of evolution of burns in 315 adult patients. Sem Hop 48:3389–3393

    CAS  PubMed  Google Scholar 

  36. Tweddell JS, Waymack JP, Warden GD, Law EJ, Jenkins M, Alexander JW (1987) Hematuria in the burned child. J Pediatr Surg 22:899–903

    Article  CAS  PubMed  Google Scholar 

  37. Chung KK, Wolf SE, Cancio LC, Alvarado R, Jones JA, McCorcle J, King BT, Barillo DJ, Renz EM, Blackbourne LH (2009) Resuscitation of severely burned military casualties: fluid begets more fluid. J Trauma 67:231–237 (discussion 237)

    Article  PubMed  Google Scholar 

  38. Leblanc M, Thibeault Y, Querin S (1997) Continuous haemofiltration and haemodiafiltration for acute renal failure in severely burned patients. Burns 23:160–165

    Article  CAS  PubMed  Google Scholar 

  39. Davies MP, Evans J, McGonigle RJ (1994) The dialysis debate: acute renal failure in burns patients. Burns 20:71–73

    Article  CAS  PubMed  Google Scholar 

  40. Holm C, Horbrand F, von Donnersmarck GH, Muhlbauer W (1999) Acute renal failure in severely burned patients. Burns 25:171–178

    Article  CAS  PubMed  Google Scholar 

  41. Haberal A, Ozdemir U (1993) Gastrointestinal and renal complications in burned patients. Eur J Plastic Surgery 16:17–21

    Google Scholar 

  42. Hubsher J, Olshan AR, Schwartz AB, Zoranski B, DeClement F, Bendlin A, Hensell D, Brezin JH, Krevolin LE, Chinitz JL (1986) Continuous arteriovenous hemofiltration for the treatment of anasarca and acute renal failure in severely burned patients. ASAIO Trans 32:401–404

    Article  CAS  PubMed  Google Scholar 

  43. Sun IF, Lee SS, Lin SD, Lai CS (2007) Continuous arteriovenous hemodialysis and continuous venovenous hemofiltration in burn patients with acute renal failure. Kaohsiung J Med Sci 23:344–351

    Article  PubMed  Google Scholar 

  44. Tremblay R, Ethier J, Querin S, Beroniade V, Falardeau P, Leblanc M (2000) Veno-venous continuous renal replacement therapy for burned patients with acute renal failure. Burns 26:638–643

    Article  CAS  PubMed  Google Scholar 

  45. Abdel-Rahman E, Moorthy V, Helgerson RB, Omari B (1997) Acute renal failure (ARF) requiring dialysis in patients with burns: 16 years experience in one center. Clin Nephrol 8:A576–A0576

    Google Scholar 

  46. Dorricott NJ, Dawson-Edwards P, Blainey JD (1968) Surgical disasters and renal failure. Proc R Soc Med 61:215–216

    CAS  PubMed  Google Scholar 

  47. Garner WL, Reiss M (2005) Burn care in Los Angeles, California: LAC + USC experience 1994–2004. Burns 31(Suppl 1):S32–S35

    Article  PubMed  Google Scholar 

  48. Gueugniaud PY (1993) Apport de l’hémofiltration continue au traitement des brûlés graves. Elsevier, Amsterdam

    Google Scholar 

  49. Holm C, Horbrand F, Mayr M, von Donnersmarck GH, Muhlbauer W (2004) Acute hyperglycaemia following thermal injury: friend or foe? Resuscitation 60:71–77

    Article  CAS  PubMed  Google Scholar 

  50. Maharaj R (2008) Acute renal injury in patients with major thermal injury. In: World Congress of Anaesthesiologists: 2–7 March 2008, Cape Town, South Africa

  51. Marshall V, Yoffa D (1965) The diagnosis and management of renal failure in surgical patients. Aust N Z J Surg 35:20–29

    Article  CAS  PubMed  Google Scholar 

  52. Aikawa N, Shinozawa Y, Ishibiki K, Abe O, Yamamoto S, Motegi M, Yoshii H, Sudoh M (1987) Clinical analysis of multiple organ failure in burned patients. Burns Incl Therm Inj 13:103–109

    CAS  PubMed  Google Scholar 

  53. Barrow RE, Jeschke MG, Herndon DN (2000) Early fluid resuscitation improves outcomes in severely burned children. Resuscitation 45:91–96

    Article  CAS  PubMed  Google Scholar 

  54. Chrysopoulo MT, Jeschke MG, Dziewulski P, Barrow RE, Herndon DN (1999) Acute renal dysfunction in severely burned adults. J Trauma 46:141–144

    Article  CAS  PubMed  Google Scholar 

  55. Hoste E, Vandeveire B, Monstrey S, Colardyn F: Acute renal failure and renal dyfunction in burn patients. In: ISBI: 1998; Jerusalem, Israel; 1998: 79

  56. Kim GH, Oh KH, Yoon JW, Koo JW, Kim HJ, Chae DW, Noh JW, Kim JH, Park YK (2003) Impact of burn size and initial serum albumin level on acute renal failure occurring in major burn. Am J Nephrol 23:55–60

    Article  PubMed  Google Scholar 

  57. Spies M, Herndon DN, Rosenblatt JI, Sanford AP, Wolf SE (2003) Prediction of mortality from catastrophic burns in children. Lancet 361:989–994

    Article  PubMed  Google Scholar 

  58. Cooper AB, Cohn SM, Zhang HS, Hanna K, Stewart TE, Slutsky AS (2006) Five percent albumin for adult burn shock resuscitation: lack of effect on daily multiple organ dysfunction score. Transfusion 46:80–89

    Article  CAS  PubMed  Google Scholar 

  59. Coca SG, Bauling P, Schifftner T, Howard CS, Teitelbaum I, Parikh CR (2007) Contribution of acute kidney injury toward morbidity and mortality in burns: a contemporary analysis. Am J Kidney Dis 49:517–523

    Article  PubMed  Google Scholar 

  60. Chung KK, Lundy JB, Matson JR, Renz EM, White CE, King BT, Barillo DJ, Jones JA, Cancio LC, Blackbourne LH, Wolf SE (2009) Continuous venovenous hemofiltration in severely burned patients with acute kidney injury: a cohort study. Crit Care 13:R62

    PubMed  Google Scholar 

  61. Mosier MJ, Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN (2010) Early acute kidney injury predicts progressive renal dysfunction and higher mortality in severely burned adults. J Burn Care Res 31:83–92

    Article  PubMed  Google Scholar 

  62. Palmieri T, Lavrentieva A, Greenhalgh D (2009) An assessment of acute kidney injury with modified RIFLE criteria in pediatric patients with severe burns. Intensive Care Med 35:2125–2129

    Article  PubMed  Google Scholar 

  63. Palmieri T, Lavrentieva A, Greenhalgh DG (2009) Acute kidney injury in critically ill burn patients. Risk factors, progression and impact on mortality. Burns 36(2):205–211

    Article  Google Scholar 

  64. Lopes JA, Jorge S, Neves FC, Caneira M, da Costa AG, Ferreira AC, Prata MM (2007) An assessment of the RIFLE criteria for acute renal failure in severely burned patients. Nephrol Dial Transplant 22:285

    Article  PubMed  Google Scholar 

  65. Mariano F, Cantaluppi V, Stella M, Romanazzi GM, Assenzio B, Cairo M, Biancone L, Triolo G, Ranieri VM, Camussi G (2008) Circulating plasma factors induce tubular and glomerular alterations in septic burns patients. Crit Care 12:R42

    Article  PubMed  Google Scholar 

  66. Steinvall I, Bak Z, Sjoberg F (2008) Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study. Crit Care 12:R124

    Article  CAS  PubMed  Google Scholar 

  67. Williams DM, Sreedhar SS, Mickell JJ, Chan JC (2002) Acute kidney failure: a pediatric experience over 20 years. Arch Pediatr Adolesc Med 156:893–900

    PubMed  Google Scholar 

  68. Hu S, Sheng Z, Zhou B, Guo Z, Lu J, Xue L, Jin H, Sun X, Sun S, Li J, Lu Y (1998) Study on delay two-phase multiple organ dysfunction syndrome. Chin Med J (Engl) 111:101–108

    CAS  Google Scholar 

  69. Rossiter K, Kulayat N, Anderson J (1995) Acute renal failure, burns & death: patterns and probabilities in the burn center (1991–1993). Clin Nephrol 6(3):474

    Google Scholar 

  70. el Danaf A (1995) Burn variables influencing survival: a study of 144 patients. Burns 21:517–520

    Article  CAS  PubMed  Google Scholar 

  71. O’Mara MS, Caushaj P, Goldfarb IW, Slater H (2000) Treatment and mortality trends among massively burned patients. Annals of burns and fire disasters 13(2):73–76

    Google Scholar 

  72. Nguyen NL, Gun RT, Sparnon AL, Ryan P (2002) The importance of initial management: a case series of childhood burns in Vietnam. Burns 28:167–172

    Article  PubMed  Google Scholar 

  73. Huang PP, Stucky FS, Dimick AR, Treat RC, Bessey PQ, Rue LW (1995) Hypertonic sodium resuscitation is associated with renal failure and death. Ann Surg 221:543–554 (discussion 554–547)

    Article  CAS  PubMed  Google Scholar 

  74. Cameron JS, Miller-Jones CM (1967) Renal function and renal failure in badly burned children. Br J Surg 54:132–141

    Article  CAS  PubMed  Google Scholar 

  75. Vertel RM, Knochel JP (1967) Nonoliguric acute renal failure. Jama 200:598–602

    Article  CAS  PubMed  Google Scholar 

  76. Saffle JR, Sullivan JJ, Tuohig GM, Larson CM (1993) Multiple organ failure in patients with thermal injury. Crit Care Med 21:1673–1683

    Article  CAS  PubMed  Google Scholar 

  77. Sabry A, El-Din AB, El-Hadidy AM, Hassan M (2009) Markers of tubular and glomerular injury in predicting acute renal injury outcome in thermal burn patients: a prospective study. Ren Fail 31:457–463

    Article  PubMed  Google Scholar 

  78. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG (1996) The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the European Society of intensive care medicine. Intensive Care Med 22:707–710

    Article  CAS  PubMed  Google Scholar 

  79. Hoste EA, Kellum JA (2006) RIFLE criteria provide robust assessment of kidney dysfunction and correlate with hospital mortality. Crit Care Med 34:2016–2017

    Article  PubMed  Google Scholar 

  80. Schiavon M, Di Landro D, Baldo M, De Silvestro G, Chiarelli A (1988) A study of renal damage in seriously burned patients. Burns Incl Therm Inj 14:107–112

    CAS  PubMed  Google Scholar 

  81. Mustonen KM, Vuola J (2008) Acute renal failure in intensive care burn patients (ARF in burn patients). J Burn Care Res 29:227–237

    PubMed  Google Scholar 

  82. Hoste EA, De Waele JJ (2008) Acute kidney injury in the intensive care unit: it’s the gene, stupid!. Crit Care Med 36:3266–3267

    Article  PubMed  Google Scholar 

  83. Bagshaw SM, George C, Gibney RT, Bellomo R (2008) A multi-center evaluation of early acute kidney injury in critically ill trauma patients. Ren Fail 30:581–589

    Article  PubMed  Google Scholar 

  84. Ostermann M, Chang RW (2007) Acute kidney injury in the intensive care unit according to RIFLE. Crit Care Med 35:1837–1843 quiz 1852

    Article  PubMed  Google Scholar 

  85. Joannidis M, Metnitz B, Bauer P, Schusterschitz N, Moreno R, Druml W, Metnitz PG (2009) Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS 3 database. Intensive Care Med 35:1692–1702

    Article  PubMed  Google Scholar 

  86. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C (2005) Acute renal failure in critically ill patients: a multinational, multicenter study. Jama 294:813–818

    Article  CAS  PubMed  Google Scholar 

  87. Metnitz PG, Krenn CG, Steltzer H, Lang T, Ploder J, Lenz K, Le Gall JR, Druml W (2002) Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Crit Care Med 30:2051–2058

    Article  PubMed  Google Scholar 

  88. Vandenbroucke JP (2004) When are observational studies as credible as randomised trials? Lancet 363:1728–1731

    Article  PubMed  Google Scholar 

  89. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP (2007) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453–1457

    Article  Google Scholar 

  90. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to thank Prof. Matthias Egger (Professor of Epidemiology, Department of Social and Preventive Medicine at the University of Berne, Switzerland) and Dr. Thomas Schioler (Senior Medical Officer, The National Board of Health, Denmark) for their valuable contributions to an earlier draft of this article. Stijn Blot is supported by a grant from the European Society of Intensive Care Medicine and iMDsoft Patient Safety Research Award 2008. Eric Hoste is Senior Clinical Investigator of the Research Foundation-Flanders (Belgium) (FWO).

Author information

Authors and Affiliations

  1. Burn Unit, Ghent University Hospital, Ghent University, Ghent, Belgium

    Nele Brusselaers, Stan Monstrey, Kirsten Colpaert, Johan Decruyenaere & Eric A. J. Hoste

  2. Department of Plastic Surgery, Ghent University Hospital, Ghent University, Ghent, Belgium

    Stan Monstrey

  3. Department of Intensive Care Medicine, Ghent University Hospital, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium

    Kirsten Colpaert, Johan Decruyenaere & Eric A. J. Hoste

  4. Department of General Internal Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium

    Nele Brusselaers & Stijn I. Blot

Authors
  1. Nele Brusselaers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stan Monstrey
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kirsten Colpaert
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Johan Decruyenaere
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Stijn I. Blot
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Eric A. J. Hoste
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eric A. J. Hoste.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brusselaers, N., Monstrey, S., Colpaert, K. et al. Outcome of acute kidney injury in severe burns: a systematic review and meta-analysis. Intensive Care Med 36, 915–925 (2010). https://doi.org/10.1007/s00134-010-1861-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-010-1861-1

Keywords

Search

Navigation