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Diabetes mellitus is an independent risk factor for ICU-acquired bloodstream infections

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Abstract

Objective

To investigate the role of diabetes as risk factor for ICU-acquired bloodstream infections (BSI).

Design

Prospective observational study.

Setting

A general eight-bed ICU of a tertiary hospital.

Patients

Three hundred and forty-three consecutive patients (63 diabetic and 280 nondiabetic) admitted in the ICU.

Methods

BSI episodes in the ICU were recorded and classified as primary, secondary, catheter-related and mixed according to strict criteria. In all patients, blood glucose was strictly controlled with a continuous insulin infusion within a range of 80–120 mg/dl.

Results

One-hundred and eighteen patients (34.4%) developed at least one BSI episode. Diabetic patients had an increased probability of developing at least one BSI episode compared with nondiabetic patients (hazard ratio = 1.66, 95% confidence interval 1.04–2.64, P = 0.034) in a Cox proportional hazards regression model adjusting for age, gender, admission category and APACHE II score at admission in the ICU and comorbidities.

Conclusions

Despite strict glycemic control, diabetic patients have a 1.7-fold probability of developing an ICU-acquired BSI compared to nondiabetic subjects.

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Conflict of interest statement

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Intensive Care Unit, Thriassio General Hospital of Eleusis, G. Gennimata Ave., 19200, Magoula, Attika, Greece

    M. Michalia, M. Kompoti, A. Koutsikou, A. Paridou & P. Clouva-Molyvdas

  2. Department of Microbiology, Thriassio General Hospital of Eleusis, Attika, Greece

    P. Giannopoulou & E. Trikka-Graphakos

Authors
  1. M. Michalia
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  2. M. Kompoti
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  3. A. Koutsikou
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  4. A. Paridou
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  5. P. Giannopoulou
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  6. E. Trikka-Graphakos
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  7. P. Clouva-Molyvdas
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Corresponding author

Correspondence to M. Kompoti.

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Michalia, M., Kompoti, M., Koutsikou, A. et al. Diabetes mellitus is an independent risk factor for ICU-acquired bloodstream infections. Intensive Care Med 35, 448–454 (2009). https://doi.org/10.1007/s00134-008-1288-0

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  • DOI: https://doi.org/10.1007/s00134-008-1288-0

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