Abstract
Objective
To compare the lithium-thermal double indicator dilution (Li-thermal), indocyanine green-thermal double indicator dilution (ICG-thermal), single thermal indicator dilution (single-thermal) and gravimetric techniques of extravascular lung water volume (EVLW) measurement in porcine models of acute lung injury.
Design
Two animal models designed to invoke a systemic inflammatory response.
Setting
Laboratory study.
Subjects
A total of 12 immature Deutsches Landschwein pigs.
Interventions
Extravascular lung water volume was measured at four time points using Li-thermal, ICG-thermal and single-thermal techniques. Measurements were performed using existing technology according to manufacturer’s instructions. Post-mortem gravimetric EVLW measurements were performed by measuring wet and dry mass of lung tissue. Measurements were compared using the Bland–Altman method. Data are presented as mean (SD).
Measurements and main results
Data were collected in 12 animals and comparison between all 4 techniques was possible in 10 animals. EVLW measured by gravimetry was 9.2 (±3.0)ml kg−1. When compared to gravimetry, both Li-thermal and ICG-thermal techniques showed minimal bias but wide limits of agreement (LOA) [Li-thermal: bias −1.8 ml kg−1 (LOA ± 13.1); ICG-thermal bias −1.0 ml kg−1 (LOA ± 6.6)]. Comparison between the single-thermal and gravimetric methods identified both considerable bias and wide LOA [+8.5 ml kg−1 (LOA ± 14.5)].
Conclusion
Clinically significant differences between EVLW measurements obtained with the gravimetric method and three in vivo indicator dilution techniques were identified. While none of the techniques could be considered ideal, the ICG-thermal method appeared more reliable than either the Li-thermal or single thermal techniques. Further research is required to determine whether the accuracy of the prototype Li-thermal technique can be improved.
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Acknowledgments
The authors wish to thank Mr. Eric Mills of LiDCO Ltd., for his advice during this study. R.M.P. formulated the hypothesis and developed the protocol with C.H. and P.R. The investigation was performed by B.M., R.G., E.C. and P.R. at Universitätsklinikum, Ulm, Germany. CW assisted in the data analysis. The manuscript was drafted by B.M., R.M.P. and C.H. All authors approved the final version.
Conflict of interest statement
This research was supported by an unrestricted educational grant from LiDCO Ltd., Cambridge, UK. R.M.P. has received speaking fees and equipment loans from Pulsion Medical Systems and a research grant from USCOM Ltd.
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Maddison, B., Giudici, R., Calzia, E. et al. Extravascular lung water volume measurement by a novel lithium-thermal indicator dilution method: comparison of three techniques to post-mortem gravimetry. Intensive Care Med 34, 2106–2111 (2008). https://doi.org/10.1007/s00134-008-1207-4
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DOI: https://doi.org/10.1007/s00134-008-1207-4