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Alveolar recruitment assessed by positron emission tomography during experimental acute lung injury

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Abstract

Objectives

To compare changes in aerated lung volumes measured by positron emission tomography (PET) and inflation volume-pressure curve (V – P) of the respiratory system, and to evaluate the reliability of PET to assess alveolar recruitment.

Design and setting

Experimental study in six anesthetized and mechanically ventilated pigs in a PET facility in an experimental university laboratory.

Interventions

Lung injury was induced by oleic acid. Animals were randomly studied in four conditions: PEEP 0 cmH2O (ZEEP) in supine position (SP), PEEP 10 cmH2O in SP, ZEEP in prone position (PP) and PEEP in PP, each applied for 30 min.

Measurements and results

With PET aerated lung volume was obtained from pulmonary density analysis using transmission scan (VAtrans) and from nitrogen-13 kinetics on emission scan (VAem). Changes in VAtrans and VAem were computed as the difference in aerated volume between conditions. VAtrans and VAem did not differ between SP and PP, on either ZEEP or PEEP, suggesting no modification in relaxation volume of the respiratory system induced by posture. Changes in VAtrans or VAem were significantly correlated with changes in aerated volume assessed from superimposed V – P curves (R 2 = 0.74 and 0.75, respectively). Alveolar recruitment assessed by PET was significantly correlated with both PaO2 (R 2 = 0.61) and PaCO2 (R 2 = 0.40) variations induced by PEEP.

Conclusions

PET is a new reliable tool of scientific interest to image lung volume and alveolar recruitment during acute lung injury.

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Acknowledgements

The authors thank Gaël Bourdin, Veronique Berthier, and Veronique Gualda for their help with animal preparation, and gratefully acknowledge the support provided by the PET facility staff of the CERMEP.

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Authors and Affiliations

  1. Service de Réanimation Médicale et d’Assistance Respiratoire, Hôpital de la Croix Rousse, 93 Grande Rue de la Croix Rousse, 69004, Lyon, France

    Jean-Christophe Richard & Claude Guerin

  2. CREATIS, CNRS UMR 5515 et INSERM Unité 630, Lyon, France

    Jean-Christophe Richard, Marc Janier, Gérard Gimenez & Claude Guerin

  3. Centre d’Étude et de Recherche Multimodal et Pluridisciplinaire en Imagerie du Vivant, Lyon, France

    Didier Le Bars, Nicolas Costes, Christian Tourvieille, Franck Lavenne & Gérard Gimenez

  4. Laboratoire d’Explorations Fonctionnelles Respiratoires, Faculté de Médecine, Marseille, France

    Fabienne Bregeon

  5. ANIMAGE, bat. CERMEP, Hôpital Neurologique, Lyon, France

    Marc Janier

Authors
  1. Jean-Christophe Richard
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  2. Didier Le Bars
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  3. Nicolas Costes
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  4. Fabienne Bregeon
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  5. Christian Tourvieille
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  6. Franck Lavenne
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  7. Marc Janier
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  8. Gérard Gimenez
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  9. Claude Guerin
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Corresponding author

Correspondence to Claude Guerin.

Additional information

This research was supported by the Hospices civils de Lyon.

This article is discussed in the editorial available at: http://dx.doi.org/10.1007/s00134-006-0372-6

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Richard, JC., Le Bars, D., Costes, N. et al. Alveolar recruitment assessed by positron emission tomography during experimental acute lung injury. Intensive Care Med 32, 1889–1894 (2006). https://doi.org/10.1007/s00134-006-0331-2

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  • DOI: https://doi.org/10.1007/s00134-006-0331-2

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