Skip to main content
Log in

Is the measurement of monocytes HLA-DR expression useful in patients with sepsis?

  • Editorial
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Cavaillon JM, Adrie C, Fitting C Adib-Conquy M (2005) Reprogramming of circulatory cells in sepsis and SIRS. J Endotoxin Res 11:311–320

    PubMed  CAS  Google Scholar 

  2. Cohen J (2002) The immunopathogenesis of sepsis. Nature 420:885–891

    Article  PubMed  CAS  Google Scholar 

  3. Cavaillon JM (2002) “Septic plasma”: an immunosuppressive milieu. Am J Respir Crit Care Med 166:1417–1418

    Article  PubMed  Google Scholar 

  4. Bone RC (1996) Sir Isaac Newton, sepsis, SIRS, and CARS. Crit Care Med 24:1125–1128

    Article  PubMed  CAS  Google Scholar 

  5. Munford RS, Pugin J (2001) Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med 163: 316–321

    Google Scholar 

  6. Volk HD, Reinke P, Docke WD (2000) Clinical aspects: from systemic inflammation to 'immunoparalysis'. Chem Immunol 74:162–177

    Article  PubMed  CAS  Google Scholar 

  7. Pangault C, Le Tulzo Y, Tattevin P, Guilloux V, Bescher N, Drenou B (2006) Down-modulation of granulocyte macrophage-colony stimulating factor receptor on monocytes during human septic shock. Crit Care Med 34:1193–1201

    Article  PubMed  CAS  Google Scholar 

  8. Le Tulzo Y, Pangault C, Amiot L, Guilloux V, Tribut O, Arvieux C, Camus C, Fauchet R, Thomas R, Drenou B (2004) Monocyte human leukocyte antigen-DR transcriptional downregulation by cortisol during septic shock. Am J Respir Crit Care Med 169:1144–1151

    Article  PubMed  Google Scholar 

  9. Pachot A, Monneret G, Brion A, Venet F, Bohe J, Bienvenu J, Mougin B, Lepape A (2005) Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients. Crit Care Med 33:31–38 discussion 236–237

    Article  PubMed  CAS  Google Scholar 

  10. Fumeaux T, Pugin J (2002) Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock. Am J Respir Crit Care Med 166:1475–1482

    Article  PubMed  Google Scholar 

  11. Nierhaus A, Montag B, Timmler N, Frings DP, Gutensohn K, Jung R, Schneider CG, Pothmann W, Brassel AK, Schulte Am Esch J (2003) Reversal of immunoparalysis by recombinant human granulocyte-macrophage colony-stimulating factor in patients with severe sepsis. Intensive Care Med 29:646–651

    PubMed  Google Scholar 

  12. Docke WD, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, Volk HD, Kox W (1997) Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 3:678–681

    Article  PubMed  CAS  Google Scholar 

  13. Nakos G, Malamou-Mitsi VD, Lachana A, Karassavoglou A, Kitsiouli E, Agnandi N, Lekka MF (2002) Immunoparalysis in patients with severe trauma and the effect of inhaled interferon-gamma. Crit Care Med 30:1488–1494

    Article  PubMed  CAS  Google Scholar 

  14. Spittler A, Roth E (2003) Is monocyte HLA-DR expression predictive for clinical outcome in sepsis? Intensive Care Med 29:1211–1212

    Article  PubMed  Google Scholar 

  15. Tschoeke SK, Moldawer LL (2005) Human leukocyte antigen expression in sepsis: what have we learned? Crit Care Med 33:236–237

    Article  PubMed  Google Scholar 

  16. Monneret G, Lepape A, Voirin N, Bohé J, Venet F, Debard AL, Thizy H, Bienvenu J, Gueyffier F, Vanhems P (2006) Intensive Care Med DOI 10.1007/s00134–0204-8

  17. Docke WD, Hoflich C, Davis KA, Rottgers K, Meisel C, Kiefer P, Weber SU, Hedwig-Geissing M, Kreuzfelder E, Tschentscher P, Nebe T, Engel A, Monneret G, Spittler A, Schmolke K, Reinke P, Kunz D (2005) Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: a multicenter standardized study. Clin Chem 51:2341–2347

    Article  PubMed  CAS  Google Scholar 

  18. Monneret G, Elmenkouri N, Bohe J, Debard AL, Gutowski MC, Bienvenu J, Lepape A (2002) Analytical requirements for measuring monocytic human lymphocyte antigen DR by flow cytometry: application to the monitoring of patients with septic shock. Clin Chem 48:1589–1592

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jérôme Pugin.

Additional information

This editorial refers to the article available at: http://dx.doi.org/10.1007/s00134-006-0204-8

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fumeaux, T., Pugin, J. Is the measurement of monocytes HLA-DR expression useful in patients with sepsis?. Intensive Care Med 32, 1106–1108 (2006). https://doi.org/10.1007/s00134-006-0205-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-006-0205-7

Navigation